DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF454

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001171560.1	Gene:	ZNF454 / 285676	HGNCID:	21200	Length:	522	Species:	Homo sapiens

Alignment Length:	474	Identity:	135/474 - (28%)
Similarity:	200/474 - (42%)	Gaps:	96/474 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 CLQLLE-----QAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTE- 127
            |..|||     |..:.:|:|:..........||:  .|...|..|| :|||.....:.||:.:|
Human   122 CASLLEWQCGGQEISLQRVVLTHPNTPSQECDES--GSTMSSSLHS-DQSQGFQPSKNAFECSEC 183

  Fly   128 --EYVMIEMLNEEQE--NVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQS 188
              .:.....||:.|:  |..|.::::..:::|.                 :..|..:..||....
Human   184 GKVFSKSSTLNKHQKIHNEKNANQKIHIKEKRY-----------------ECRECGKAFHQSTHL 231

  Fly   189 GDQQEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGA 253
            ...|..| |.|..:|.:..                 ...|.|.:....|..|
Human   232 IHHQRIH-TGEKPYECKEC-----------------GKAFSVSSSLTYHQKI------------- 265

  Fly   254 IDEVIGEETLELEGDGR---------EEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTV 309
               ..||:..|....|:         ..|.:...|.                       |:.|.:
Human   266 ---HTGEKPFECNLCGKAFIRNIHLAHHHRIHTGEK-----------------------PFKCNI 304

  Fly   310 CQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTS 374
            |:|||..:..|.:|...|..||.|:|.||||......::.:|...||..||.:|:.||:.:|..|
Human   305 CEKAFVCRAHLTKHQNIHSGEKPYKCNECGKAFNQSTSFLQHQRIHTGEKPFECNECGKAFRVNS 369

  Fly   375 SLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISH 439
            ||..|:|.|..:|||.|::||:.:.......||:..||||:||.|.||:||:.|.|:|.||:..|
Human   370 SLTEHQRIHTGEKPYKCNECGKAFRDNSSFARHRKIHTGEKPYRCGLCEKAFRDQSALAQHQRIH 434

  Fly   440 TGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCE 504
            ||:|.:||.||....|..|...:|..:|:..|.:||.:|..||..:::|..|.|:|:||||:||.
Human   435 TGEKPYTCNICEKAFSDHSALTQHKRIHTREKPYKCKICEKAFIRSTHLTQHQRIHTGEKPYKCN 499

  Fly   505 VCVKAFPTKKRLASHMRVH 523
            .|.|||.....|..|.|.|
Human   500 KCGKAFNQTANLIQHQRHH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	7/26 (27%)
		COG5048	<297..451	CDD:227381	63/153 (41%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	9/19 (47%)
		COG5048	<387..523	CDD:227381	59/135 (44%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF454	NP_001171560.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..170		8/25 (32%)
		zf-C2H2	178..200	CDD:278523	5/21 (24%)
		C2H2 Zn finger	180..200	CDD:275368	4/19 (21%)
		COG5048	186..522	CDD:227381	116/407 (29%)
		C2H2 Zn finger	218..238	CDD:275368	4/19 (21%)
		zf-H2C2_2	230..254	CDD:290200	5/41 (12%)
		C2H2 Zn finger	246..266	CDD:275368	4/52 (8%)
		zf-H2C2_2	258..283	CDD:290200	6/40 (15%)
		C2H2 Zn finger	274..294	CDD:275368	2/19 (11%)
		zf-H2C2_2	286..311	CDD:290200	8/47 (17%)
		C2H2 Zn finger	302..322	CDD:275368	7/19 (37%)
		zf-H2C2_2	314..339	CDD:290200	11/24 (46%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		zf-H2C2_2	342..365	CDD:290200	8/22 (36%)
		C2H2 Zn finger	358..378	CDD:275368	9/19 (47%)
		zf-H2C2_2	370..393	CDD:290200	11/22 (50%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-H2C2_2	398..421	CDD:290200	12/22 (55%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	426..450	CDD:290200	11/23 (48%)
		C2H2 Zn finger	442..462	CDD:275368	6/19 (32%)
		zf-H2C2_2	454..479	CDD:290200	8/24 (33%)
		C2H2 Zn finger	470..490	CDD:275368	7/19 (37%)
		zf-H2C2_2	482..507	CDD:290200	14/24 (58%)
		C2H2 Zn finger	498..518	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910