DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and ZBTB11

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_055230.2	Gene:	ZBTB11 / 27107	HGNCID:	16740	Length:	1053	Species:	Homo sapiens

Alignment Length:	588	Identity:	115/588 - (19%)
Similarity:	203/588 - (34%)	Gaps:	200/588 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 DSTEEYVMIEML------------NEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDD 176
            ||..|...::::            |.|...|:|:..:|::|:    .::...|:..:..::..:|
Human   404 DSHPEMESVDLITKNNQTELETSNNRENNTVSNIHPKLSKEN----VISSSPEDSGMGNDISAED 464

  Fly   177 ELSEEEHQLAQSGDQ----QEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAH 237
            ..:|:..:..|..||    ||..:...:..:|.|.:..|   ::........|..: :....|..
Human   465 ICAEDIPKHRQKVDQPLKDQENLVASTAKTDFGPDDDTY---RSRLRQRSVNEGAY-IRLHKGME 525

  Fly   238 DAILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGE- 301
            ..:...:.:   .:.|:.:|             .:.|:...:.:.:.:...:|:.:.|....||
Human   526 KKLQKRKAV---PKSAVQQV-------------AQKLVQRGKKMKQPKRDAKENTEEASHKCGEC 574

  Fly   302 -------------------ALPYVCTVCQKAFRQQCRLNQHMRSHV------------------- 328
                               |..|.|.:|:|.|:....|..|:..|.
Human   575 GMVFQRRYALIMHKLKHERARDYKCPLCKKQFQYSASLRAHLIRHTRKDAPSSSSSNSTSNEASG 639

  Fly   329 -------DEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEK 386
                   .::::.|..||:.|..|.:.:.|||.||.||||.|.:||:.:.....|.:|:..|..:
Human   640 TSSEKGRTKREFICSICGRTLPKLYSLRIHMLKHTGVKPHACQVCGKTFIYKHGLKLHQSLHQSQ 704

  Fly   387 KPYNCDQCGRGYAAFDHLRRHKLTHTGE-------------------------------RPYACD 420
            |.:.|:.|.:.:.....|:.|...||||                               |.|.|.
Human   705 KQFQCELCVKSFVTKRSLQEHMSIHTGESKYLCSVCGKSFHRGSGLSKHFKKHQPKPEVRGYHCT 769

  Fly   421 LCDKAYYDSSSLRQHKISHTGKKAF---------------------------------------- 445
            .|:|:::::..||||...|.|.|.|
Human   770 QCEKSFFEARDLRQHMNKHLGVKPFQCQFCDKCYSWKKDWYSHVKSHSVTEPYRCNICGKEFYEK 834

  Fly   446 ------------------------TCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTS 486
                                    .||.||...:|...|::||..|.|||..:|..||.|:....
Human   835 ALFRRHVKKATHGKKGRAKQNLERVCEKCGRKFTQLREYRRHMNNHEGVKPFECLTCGVAWADAR 899

  Fly   487 NLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHM-------------------RVHNKESPVTAT 532
            :|..|||.|:||:|:.|.||.:|:...:.|..||                   :.||:.:.|...
Human   900 SLKRHVRTHTGERPYVCPVCSEAYIDARTLRKHMTKFHRDYVPCKIMLEKDTLQFHNQGTQVAHA 964

  Fly   533 VAV 535
            |::
Human   965 VSI 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	55/294 (19%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		COG5048	<387..523	CDD:227381	53/249 (21%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		zf-H2C2_2	403..426	CDD:290200	11/53 (21%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/38 (18%)
ZBTB11	NP_055230.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..173
		BTB	204..305	CDD:279045
		BTB	215..306	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..566		2/19 (11%)
		C2H2 Zn finger	571..591	CDD:275368	2/19 (11%)
		C2H2 Zn finger	599..619	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..643		1/23 (4%)
		C2H2 Zn finger	653..673	CDD:275368	8/19 (42%)
		zf-H2C2_2	665..690	CDD:290200	12/24 (50%)
		C2H2 Zn finger	681..701	CDD:275368	5/19 (26%)
		C2H2 Zn finger	709..729	CDD:275368	4/19 (21%)
		zf-H2C2_2	721..746	CDD:290200	6/24 (25%)
		C2H2 Zn finger	737..757	CDD:275368	0/19 (0%)
		C2H2 Zn finger	768..788	CDD:275368	7/19 (37%)
		zf-H2C2_2	780..804	CDD:290200	8/23 (35%)
		C2H2 Zn finger	796..816	CDD:275368	0/19 (0%)
		C2H2 Zn finger	860..880	CDD:275368	8/19 (42%)
		C2H2 Zn finger	888..908	CDD:275368	8/19 (42%)
		zf-H2C2_2	900..923	CDD:290200	11/22 (50%)
		C2H2 Zn finger	916..937	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010