DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and Zfp651

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001160116.1	Gene:	Zfp651 / 270210	MGIID:	2670992	Length:	729	Species:	Mus musculus

Alignment Length:	559	Identity:	140/559 - (25%)
Similarity:	221/559 - (39%)	Gaps:	117/559 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CKLH--KPLQEEIDLG-----SEGSTTLASM------LNYCTGLSFEPQDGAAMPQHICLHCLQL 72
            |||.  :.|:.|:|..     .|.|..:..:      |:..||...:|..||
Mouse   234 CKLESGEGLEPELDASGTYGHQEQSQIIVEVNLNNQTLHVSTGPEGKPGSGA------------- 285

  Fly    73 LEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNE 137
                 |...:|:..::    |:           |.||..:.::........:..||       .|
Mouse   286 -----NPATVVLGQED----GM-----------QGHSEEEEEEGGGSGGGEEEEEE-------EE 323

  Fly   138 EQENVANLDEELAEE---DRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQ-------LAQSGDQQ 192
            |:|.....:||..||   |.|     .||:||....|  ||.|.||||.:       ...:|.|.
Mouse   324 EEEGSQGEEEEEEEEGPSDHR-----EDEDEEDGPSE--QDAESSEEEREAEGRQDPAGPAGCQG 381

  Fly   193 EE-----HITMESVHEFQPAEVEYVTIKNEFETIVTEEDEF-----EVMNDSGAHDAILDCQMIV 247
            .:     |..|.:....|          |.......|.:|.     :....|||
Mouse   382 SQVDPPPHSRMSTRSRGQ----------NTRRRATPEPEEAGRRGGKRPKASGA----------- 425

  Fly   248 IPAEGAIDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQK 312
            :||..|.|.:..:..||    .:::|...:...|..:..:||:.::     ...:...:|..|.|
Mouse   426 VPASQAADGLGAKVKLE----EKQQHPCQKCPRVFNNRWYLEKHMN-----VTHSRMQICGQCGK 481

  Fly   313 AFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEH-MLTHTNV-KPHQCSICGRFYRTTSS 375
            .|..:..|..|.::.. |:..:|..|||..|.|.:..|| .:.|... |...|.||.:.:.|.:.
Mouse   482 RFLLESELQLHRQTDC-ERNIQCMTCGKAFKKLWSLHEHNKIVHGYAEKKFSCEICEKKFHTMAH 545

  Fly   376 LAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHT 440
            :..|...|.:..|:.|:.||:.:.....|:.|.|.|:||:|:.|:.|::.:.....||.|...|.
Mouse   546 VRKHMVAHTKDMPFTCETCGKSFKRSMSLKVHSLQHSGEKPFRCENCNERFQYKYQLRSHMSIHI 610

  Fly   441 GKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEV 505
            |.|.|.|:.||...:.|..:.:||..|:|.|.:.|::||.:||...|:..|.|.|:||||:.|:|
Mouse   611 GHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPYICEICGKSFTSRPNMKRHRRTHTGEKPYPCDV 675

  Fly   506 CVKAFPTKKRLASH----MRVHNKESPVTATVAVQSINP 540
            |.:.|.....|.:|    .||.:......||:....:.|
Mouse   676 CGQRFRFSNMLKAHKEKCFRVSHPLPGDPATLPATHLQP 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	16/82 (20%)
		COG5048	<297..451	CDD:227381	44/155 (28%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	8/20 (40%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		COG5048	<387..523	CDD:227381	49/139 (35%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/23 (30%)
Zfp651	NP_001160116.1	BTB	32..138	CDD:279045
		BTB	46..141	CDD:197585
		C2H2 Zn finger	449..468	CDD:275368	3/23 (13%)
		C2H2 Zn finger	476..495	CDD:275368	6/18 (33%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
		COG5048	531..>612	CDD:227381	23/80 (29%)
		C2H2 Zn finger	533..553	CDD:275368	5/19 (26%)
		zf-H2C2_2	545..570	CDD:290200	6/24 (25%)
		C2H2 Zn finger	561..581	CDD:275368	6/19 (32%)
		zf-H2C2_2	573..596	CDD:290200	9/22 (41%)
		cxxc_20_cxxc	588..>632	CDD:274982	13/43 (30%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		C2H2 Zn finger	617..637	CDD:275368	6/19 (32%)
		zf-H2C2_2	629..654	CDD:290200	9/24 (38%)
		COG5048	641..>690	CDD:227381	19/48 (40%)
		C2H2 Zn finger	645..665	CDD:275368	8/19 (42%)
		zf-H2C2_2	657..680	CDD:290200	11/22 (50%)
		C2H2 Zn finger	673..689	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839977
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930