DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and GFI1

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001120687.1	Gene:	GFI1 / 2672	HGNCID:	4237	Length:	422	Species:	Homo sapiens

Alignment Length:	160	Identity:	63/160 - (39%)
Similarity:	94/160 - (58%)	Gaps:	1/160 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 HQCSICGRFYRTTSSLAVH-KRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDK 424
            ::|..|.:.:.|...|.|| :|:|:..:|:.|:.||:.:.....|.:||..|:.||.:.|.:|.|
Human   255 YKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGK 319

  Fly   425 AYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLN 489
            ::..||:|..|.:.|:..:.:.|:.||....|||..|||..:|:|.|.|||.|||.||:.:|||.
Human   320 SFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLI 384

  Fly   490 AHVRLHSGEKPFKCEVCVKAFPTKKRLASH 519
            .|.|.|:|.|||.|::|.|.|..|..|..|
Human   385 THSRKHTGFKPFGCDLCGKGFQRKVDLRRH 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	27/90 (30%)
		C2H2 Zn finger	307..327	CDD:275368
		C2H2 Zn finger	335..355	CDD:275368
		C2H2 Zn finger	363..383	CDD:275368	7/20 (35%)
		COG5048	<387..523	CDD:227381	55/133 (41%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	11/19 (58%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	7/17 (41%)
GFI1	NP_001120687.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..109
		SNAG domain. /evidence=ECO:0000250	1..20
		Required for interaction with RELA. /evidence=ECO:0000269\|PubMed:20547752	140..257		0/1 (0%)
		COG5048	<254..416	CDD:227381	63/160 (39%)
		C2H2 Zn finger	257..278	CDD:275368	7/20 (35%)
		C2H2 Zn finger	286..306	CDD:275368	6/19 (32%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		C2H2 Zn finger	342..362	CDD:275368	9/19 (47%)
		C2H2 Zn finger	370..390	CDD:275368	11/19 (58%)
		C2H2 Zn finger	398..417	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910