DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF324

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_005258770.1	Gene:	ZNF324 / 25799	HGNCID:	14096	Length:	558	Species:	Homo sapiens

Alignment Length:	349	Identity:	118/349 - (33%)
Similarity:	167/349 - (47%)	Gaps:	48/349 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 ETLELEGDGREEH-----------LLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAF 314
            :.||..| ||..|           ||...|....||  |.|:|.     |||. .:.|..|.|.|
Human   216 QDLEAAG-GRGHHRMGAVWQEPHRLLGGQEPSTWDE--LGEALH-----AGEK-SFECRACSKVF 271

  Fly   315 RQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVH 379
            .:...|.:|:|:|..|:.|||.:|||......:..:|...|:...|:.|.:||:.:|.:|||..|
Human   272 VKSSDLLKHLRTHTGERPYECAQCGKAFSQTSHLTQHQRIHSGETPYACPVCGKAFRHSSSLVRH 336

  Fly   380 KRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKA 444
            :|.|..:|.:.|.:||:.::...:|.:|:..|.|.|||||..|.:.:..:|.|.||:.:|||:|.
Human   337 QRIHTAEKSFRCSECGKAFSHGSNLSQHRKIHAGGRPYACAQCGRRFCRNSHLIQHERTHTGEKP 401

  Fly   445 FTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKA 509
            |.|.:||...||.|...||..||:|.|...|..||.||:.:|||..|..||:||:||:|..|.||
Human   402 FVCALCGAAFSQGSSLFKHQRVHTGEKPFACPQCGRAFSHSSNLTQHQLLHTGERPFRCVDCGKA 466

  Fly   510 FPTKKRLASHMRVHNKESPVTATVAVQ--------------------------SINPPSRQAGAE 548
            |.....|.||.|:|..|.|...|...:                          |::|.:|.....
Human   467 FAKGAVLLSHRRIHTGEKPFVCTQCGRAFRERPALFHHQRIHTGEKTVRRSRASLHPQARSVAGA 531

  Fly   549 GATGGGATGGSPTGGGATGGSATN 572
            .:.|..|....||  .|:|.:|.:
Human   532 SSEGAPAKETEPT--PASGPAAVS 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	55/153 (36%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	9/19 (47%)
		COG5048	<387..523	CDD:227381	59/135 (44%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
ZNF324	XP_005258770.1	KRAB	6..66	CDD:214630
		KRAB	6..45	CDD:279668
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		COG5048	<268..468	CDD:227381	80/199 (40%)
		zf-H2C2_2	276..301	CDD:290200	11/24 (46%)
		C2H2 Zn finger	292..312	CDD:275368	5/19 (26%)
		zf-H2C2_2	304..329	CDD:290200	6/24 (25%)
		C2H2 Zn finger	320..340	CDD:275368	9/19 (47%)
		zf-H2C2_2	332..357	CDD:290200	9/24 (38%)
		C2H2 Zn finger	348..368	CDD:275368	5/19 (26%)
		zf-C2H2	374..396	CDD:278523	8/21 (38%)
		C2H2 Zn finger	376..396	CDD:275368	6/19 (32%)
		zf-H2C2_2	388..413	CDD:290200	11/24 (46%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		zf-H2C2_2	416..441	CDD:290200	11/24 (46%)
		C2H2 Zn finger	432..452	CDD:275368	9/19 (47%)
		COG5048	437..>524	CDD:227381	26/86 (30%)
		zf-H2C2_2	444..468	CDD:290200	13/23 (57%)
		C2H2 Zn finger	460..480	CDD:275368	9/19 (47%)
		zf-H2C2_2	473..495	CDD:290200	8/21 (38%)
		C2H2 Zn finger	488..508	CDD:275368	1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930