DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZKSCAN5

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001305011.1	Gene:	ZKSCAN5 / 23660	HGNCID:	12867	Length:	839	Species:	Homo sapiens

Alignment Length:	548	Identity:	134/548 - (24%)
Similarity:	221/548 - (40%)	Gaps:	133/548 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 HICLHCLQLLEQAFNF--KRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQ------ 120
            |.|..|.:...||.||  .|.:...::..:.|    .|...:..:.|.....:.|..::
Human   346 HRCSDCGKFFLQASNFIQHRRIHTGEKPFKCG----ECGKSYNQRVHLTQHQRVHTGEKPYKCQV 406

  Fly   121 --QAFDSTEEYVMIEML---------NEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQ 174
              :||..:...|....:         ||..:|... ...|.|..:|.|.    |:.:..:::..:
Human   407 CGKAFRVSSHLVQHHSVHSGERPYGCNECGKNFGR-HSHLIEHLKRHFR----EKSQRCSDKRSK 466

  Fly   175 DDELSEEEHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDA 239
            :.:||                 ..:.:.|:..|::|   :..:.:..|::..:|    ..|
Human   467 NTKLS-----------------VKKKISEYSEADME---LSGKTQRNVSQVQDF----GEG---- 503

  Fly   240 ILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALP 304
               |:.     :|.:|...|....|:.|....:.:           ::.|........:.||. |
Human   504 ---CEF-----QGKLDRKQGIPMKEILGQPSSKRM-----------NYSEVPYVHKKSSTGER-P 548

  Fly   305 YVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRF 369
            :.|..|.|:|.|...|.||.|.|..||.:.||||||......:..:|...||..||:.|.:||:.
Human   549 HKCNECGKSFIQSAHLIQHQRIHTGEKPFRCEECGKSYNQRVHLTQHQRVHTGEKPYTCPLCGKA 613

  Fly   370 YRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLR----------------------------R 406
            :|..|.|..|:..|:.::|:.|::||:|:....||.                            .
Human   614 FRVRSHLVQHQSVHSGERPFKCNECGKGFGRRSHLAGHLRLHSREKSHQCRECGEIFFQYVSLIE 678

  Fly   407 HKLTHTG----------------------------ERPYACDLCDKAYYDSSSLRQHKISHTGKK 443
            |::.|.|                            |:||.||:|.||:..||.|.||..:||.:|
Human   679 HQVLHMGQKNEKNGICEEAYSWNLTVIEDKKIELQEQPYQCDICGKAFGYSSDLIQHYRTHTAEK 743

  Fly   444 AFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVK 508
            .:.|:||...:.|.|..|:|..::|..|:|:|..||..||..|:||.|.|:|:|||||:|:.|..
Human   744 PYQCDICRENVGQCSHTKQHQKIYSSTKSHQCHECGRGFTLKSHLNQHQRIHTGEKPFQCKECGM 808

  Fly   509 AFPTKKRLASHMRVHNKESPVTATVAVQ 536
            .|.....|..|:|.|.:..|:. |::|:
Human   809 NFSWSCSLFKHLRSHERTDPIN-TLSVE 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	8/28 (29%)
		COG5048	<297..451	CDD:227381	62/209 (30%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	58/191 (30%)
		C2H2 Zn finger	391..411	CDD:275368	7/47 (15%)
		zf-H2C2_2	403..426	CDD:290200	12/78 (15%)
		C2H2 Zn finger	419..439	CDD:275368	10/19 (53%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
ZKSCAN5	NP_001305011.1	SCAN	46..155	CDD:128708
		SCAN	47..134	CDD:280241
		KRAB	222..257	CDD:279668
		COG5048	318..762	CDD:227381	103/472 (22%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		zf-H2C2_2	360..385	CDD:290200	5/28 (18%)
		C2H2 Zn finger	376..396	CDD:275368	3/23 (13%)
		zf-H2C2_2	388..411	CDD:290200	2/22 (9%)
		C2H2 Zn finger	404..424	CDD:275368	3/19 (16%)
		C2H2 Zn finger	432..452	CDD:275368	5/20 (25%)
		zf-C2H2	549..571	CDD:278523	9/21 (43%)
		C2H2 Zn finger	551..571	CDD:275368	9/19 (47%)
		zf-H2C2_2	563..588	CDD:290200	13/24 (54%)
		C2H2 Zn finger	579..599	CDD:275368	7/19 (37%)
		zf-H2C2_2	591..614	CDD:290200	8/22 (36%)
		C2H2 Zn finger	607..627	CDD:275368	7/19 (37%)
		zf-H2C2_2	619..644	CDD:290200	8/24 (33%)
		C2H2 Zn finger	635..655	CDD:275368	6/19 (32%)
		C2H2 Zn finger	663..683	CDD:275368	1/19 (5%)
		zf-C2H2	717..739	CDD:278523	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	10/19 (53%)
		C2H2 Zn finger	747..795	CDD:275368	20/47 (43%)
		COG5048	758..>823	CDD:227381	28/64 (44%)
		zf-C2H2	773..795	CDD:278523	11/21 (52%)
		zf-H2C2_2	787..811	CDD:290200	12/23 (52%)
		C2H2 Zn finger	803..823	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910