DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp426

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001103779.1	Gene:	Zfp426 / 235028	MGIID:	1920248	Length:	550	Species:	Mus musculus

Alignment Length:	522	Identity:	133/522 - (25%)
Similarity:	222/522 - (42%)	Gaps:	91/522 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 QDGAAMPQHICLHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQ 120
            |:.....:.:.:.||...::..:|:.:::|                |.:.:..|.|..|::
Mouse    18 QERKIAAEMMLVDCLTDDQELVSFEDVIVD----------------FTQEEWSSLNPDQRN---- 62

  Fly   121 QAFDSTEEYVMIEMLNEEQENVANL--------------DEELAEEDRRIF---AMTVDE----- 163
                     :..:::.|..:|:|.:              .||.::..:.:|   .:.::.
Mouse    63 ---------LYRDVMLENYQNLATVGYQLIKPSLISWLEQEEFSKGQKIVFPEWKLQLETKCSAF 118

  Fly   164 EEEFLTEEVDQDDEL------SEEEHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFETIV 222
            ::|||...:....::      ..|.....|.||...|...:.:..:.|||:..|...:...:.::
Mouse   119 QQEFLRGNISSRMQMQTGINRGRELCDGTQYGDFFSELSPLRTDMKTQPAQDNYGCSQYRKDFLM 183

  Fly   223 TEE--------DEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGR----EEHLL 275
            .:.        .||....::|           :.|.:..||  ..|:..|....|:    :.||.
Mouse   184 LQRKNCAGEKLSEFSQSEETG-----------MTPVKEKID--TQEKGFECSDCGKSFMSQSHLQ 235

  Fly   276 PEAEDVCEDE---------DFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEK 331
            ........|:         .|:...|.....|.....|:.|..|.|.:|....||.|||:|..||
Mouse   236 THQRTHSGDKLYEWNECGRSFINSRLAVLIETLNAKKPHRCKECGKGYRYPAYLNIHMRTHTGEK 300

  Fly   332 QYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGR 396
            .|||:||||...:..:::.|..|||..||:.||.||:.:...|.|::|.|:|...|||.|.:||:
Mouse   301 PYECKECGKAFNYSNSFQIHGRTHTGEKPYVCSQCGKAFTQHSGLSIHVRSHTGDKPYGCKECGK 365

  Fly   397 GYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYK 461
            .:.....|.:|..|||||:|:.|..|.||:..||:|..|...|..:|...|:|||......|...
Mouse   366 AFLTSSRLIQHIRTHTGEKPFVCVKCGKAFAISSNLNGHLKLHAEEKTCECKICGKAFGYLSCLN 430

  Fly   462 KHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKE 526
            .||..|:..|::.|..||.||.::::|..|:|:|:||||::|:.|.|||........|.|.|..|
Mouse   431 NHMRTHNAKKSYTCKECGKAFNYSTHLKIHMRIHTGEKPYECKQCGKAFSHSTSFQIHERTHTGE 495

  Fly   527 SP 528
            .|
Mouse   496 KP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	5/34 (15%)
		COG5048	<297..451	CDD:227381	62/153 (41%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	53/135 (39%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
Zfp426	NP_001103779.1	KRAB	39..96	CDD:214630	10/85 (12%)
		KRAB	39..78	CDD:279668	9/67 (13%)
		COG5048	<175..337	CDD:227381	44/174 (25%)
		zf-C2H2	219..241	CDD:278523	4/21 (19%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	276..296	CDD:275368	9/19 (47%)
		zf-H2C2_2	288..313	CDD:290200	15/24 (63%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		zf-H2C2_2	316..341	CDD:290200	10/24 (42%)
		COG5048	<328..480	CDD:227381	61/151 (40%)
		C2H2 Zn finger	332..352	CDD:275368	8/19 (42%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		zf-H2C2_2	373..396	CDD:290200	12/22 (55%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		zf-H2C2_2	429..453	CDD:290200	9/23 (39%)
		zf-C2H2	442..464	CDD:278523	8/21 (38%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		zf-H2C2_2	456..481	CDD:290200	13/24 (54%)
		C2H2 Zn finger	472..492	CDD:275368	7/19 (37%)
		zf-H2C2_2	484..507	CDD:290200	5/14 (36%)
		C2H2 Zn finger	500..520	CDD:275368
		C2H2 Zn finger	530..550	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000