DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp768

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_666314.1	Gene:	Zfp768 / 233890	MGIID:	2384582	Length:	568	Species:	Mus musculus

Alignment Length:	567	Identity:	151/567 - (26%)
Similarity:	210/567 - (37%)	Gaps:	164/567 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 EARCSSFHESQTHSPNQ--SQQHDQQQQAFDSTEEYVMIEMLNEEQE---NVANLDEELAEEDRR 155
            ||..........||||.  |.:...:..|.:::|        |||.|   ...|.|.|:
Mouse     4 EASSWGLESRDVHSPNAVGSPEGSLKDPAGNTSE--------NEEGEISQREGNGDYEV------ 54

  Fly   156 IFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMES--------VHEFQPAEVEYV 212
                   ||..|..|....:.|....|.: :||...:.|....||        ..||.|...|..
Mouse    55 -------EEIPFGLEPQSPEFEPQSPEFE-SQSPRFEPESPGFESRSPGFVPPSPEFAPRSPESD 111

  Fly   213 TIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEV---IGEETLELE-------- 266
            ....|||   ::..::| ....|.|.....|:    |.....:..   .|.::.|.|
Mouse   112 PQSPEFE---SQSPKYE-PRSPGCHPRSPGCE----PGSPRYEPKSPGYGSKSPEFESQSPGYES 168

  Fly   267 ----------GD-----------------------GREEHLLPEAEDVCE-----------DEDF 287
                      ||                       |.|..|.||.::...           .:.|
Mouse   169 QSPGYEPQNSGDGVQNSEFKTHSPEFETQSSKFQEGAEMPLSPEEKNPLSISLGVHPLDSFTQGF 233

  Fly   288 LEESLDSAPP---TAGEAL-----------------------------------PYVCTVCQKAF 314
            .|:...:.||   .:|..|                                   |.:|.:|.|:|
Mouse   234 GEQPTGALPPFDMPSGALLAAPQFEMLQNPLNLTGTLRGPGRRGGRARGGQGPRPNICGICGKSF 298

  Fly   315 RQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVH 379
            .:...|.||.|.|..||.|:||.|.|......:..:|..|||..:|::|..||:.:..:|.|..|
Mouse   299 GRGSTLIQHQRIHTGEKPYKCEVCSKAFSQSSDLIKHQRTHTGERPYKCPRCGKAFADSSYLLRH 363

  Fly   380 KRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKA 444
            :|||:.:|||.|..||:.:....:|.||:.||:.||||:|..|.|.|..:||||.|:..|||::.
Mouse   364 QRTHSGQKPYKCPHCGKAFGDSSYLLRHQRTHSHERPYSCPECGKCYSQNSSLRSHQRVHTGQRP 428

  Fly   445 FTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCG-----------HA----------------- 481
            |:|.|||...||:|....|...|:..|..||..||           ||
Mouse   429 FSCGICGKSFSQRSALIPHARSHAREKPFKCPECGKRFGQSSVLAIHARTHLPGRTYSCPDCGKT 493

  Fly   482 FTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            |..:|.|..|.|.|:||:|::|.||.|.|.....|..|.|||:.|.|
Mouse   494 FNRSSTLIQHQRSHTGERPYRCAVCGKGFCRSSTLLQHHRVHSGERP 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	64/191 (34%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	61/163 (37%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	10/47 (21%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
Zfp768	NP_666314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..223		49/248 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..247		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..287		0/22 (0%)
		C2H2 Zn finger	291..311	CDD:275368	8/19 (42%)
		zf-H2C2_2	304..328	CDD:290200	12/23 (52%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		COG5048	<327..532	CDD:227381	73/204 (36%)
		zf-H2C2_2	331..355	CDD:290200	8/23 (35%)
		C2H2 Zn finger	347..367	CDD:275368	7/19 (37%)
		zf-H2C2_2	359..382	CDD:290200	11/22 (50%)
		zf-C2H2	373..395	CDD:278523	7/21 (33%)
		C2H2 Zn finger	375..395	CDD:275368	6/19 (32%)
		zf-C2H2	401..423	CDD:278523	10/21 (48%)
		C2H2 Zn finger	403..423	CDD:275368	9/19 (47%)
		zf-H2C2_2	415..440	CDD:290200	12/24 (50%)
		C2H2 Zn finger	431..451	CDD:275368	8/19 (42%)
		zf-H2C2_2	447..466	CDD:290200	7/18 (39%)
		C2H2 Zn finger	459..479	CDD:275368	5/19 (26%)
		zf-C2H2	485..507	CDD:278523	5/21 (24%)
		C2H2 Zn finger	487..507	CDD:275368	5/19 (26%)
		zf-H2C2_2	500..522	CDD:290200	11/21 (52%)
		C2H2 Zn finger	515..535	CDD:275368	8/19 (42%)
		zf-H2C2_2	528..552	CDD:290200	7/13 (54%)
		zf-C2H2	541..563	CDD:278523	151/567 (27%)
		C2H2 Zn finger	543..563	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010