DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF510

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001300988.1	Gene:	ZNF510 / 22869	HGNCID:	29161	Length:	683	Species:	Homo sapiens

Alignment Length:	554	Identity:	146/554 - (26%)
Similarity:	218/554 - (39%)	Gaps:	145/554 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LNYCTGLSFEPQDGAAMPQHICLHCLQLLEQAFNFKRMVIDSDELLRLGL---DEARCSSFHESQ 106
            |||...|...|:             .|.|||||          |..::|.   |:|.|...:.|
Human   235 LNYNENLPKHPK-------------FQTLEQAF----------ECNKIGKAFNDKANCVKHNSS- 275

  Fly   107 THSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEE 171
             |:...|.:.|:                                      |....|::..|
Human   276 -HTGETSSKDDE--------------------------------------FRKNCDKKTLF---- 297

  Fly   172 VDQDDELSEEEHQLAQSGDQQEEHITMESV-HEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSG 235
                      :|:...:|   ::|:.:... ..|:.:.||      |:..:......:| :|.||
Human   298 ----------DHRRTGTG---KKHLHLNQCGKSFEKSTVE------EYNKLNMGIKHYE-LNPSG 342

  Fly   236 ------AHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDS 294
                  ||  :.|.|..||           ||...:..|..:..:  ::.:..|::...:.|:..
Human   343 NNFNRKAH--LTDPQTAVI-----------EENPLVSNDRTQTWV--KSSEYHENKKSYQTSVHR 392

  Fly   295 APPTAGEAL-PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNV 358
            ....:...: ||.|..|.|:|.|:..|.||.|:|..||.:||.||||......:...|...||..
Human   393 VRRRSHSMMKPYKCNECGKSFCQKGHLIQHQRTHTGEKPFECSECGKTFSQKSHLSTHQRIHTAE 457

  Fly   359 KPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCD 423
            ||::|:.||:.:...|:|..|:|.|..:|||.|.:||:.:.....||.|...||||:.:.|:.|.
Human   458 KPYKCNECGKTFVQKSTLRGHQRIHTGEKPYECSECGKTFVQKSTLRDHHRIHTGEKSFQCNQCG 522

  Fly   424 KAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNL 488
            |.:...|:||.|:.:|||:|.:.|..|.....:|....:|...|:|.|..||:.||..|..||.|
Human   523 KTFGQKSNLRIHQRTHTGEKTYQCNECEKSFWRKDHLIQHQKTHTGEKPFKCNECGKTFARTSTL 587

  Fly   489 NAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQSINPPSRQAGAEGATGG 553
            ..|.|:|:|||||||..|.|.|..|..|:.|.|:|..|.|......
Human   588 RVHQRIHTGEKPFKCNECGKKFVRKAILSDHQRIHTGEKPFQCNKC------------------- 633

  Fly   554 GATGGSPTGGGATGGSATNLHITEVHEQPVSTSK 587
                      |.|.|..:||.|   |::..|..|
Human   634 ----------GKTFGQKSNLRI---HQRTHSGEK 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	12/45 (27%)
		COG5048	<297..451	CDD:227381	58/154 (38%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	56/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	4/19 (21%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	13/22 (59%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF510	NP_001300988.1	KRAB	46..105	CDD:214630
		KRAB	46..85	CDD:279668
		COG5048	240..663	CDD:227381	143/549 (26%)
		C2H2 Zn finger	256..276	CDD:275368	5/21 (24%)
		zf-C2H2	404..426	CDD:278523	10/21 (48%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		zf-H2C2_2	418..443	CDD:290200	13/24 (54%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		zf-H2C2_2	446..471	CDD:290200	8/24 (33%)
		C2H2 Zn finger	462..482	CDD:275368	7/19 (37%)
		zf-H2C2_2	475..499	CDD:290200	10/23 (43%)
		C2H2 Zn finger	490..510	CDD:275368	6/19 (32%)
		zf-H2C2_2	503..525	CDD:290200	10/21 (48%)
		zf-C2H2	516..538	CDD:278523	7/21 (33%)
		C2H2 Zn finger	518..538	CDD:275368	7/19 (37%)
		zf-H2C2_2	530..555	CDD:290200	9/24 (38%)
		C2H2 Zn finger	546..566	CDD:275368	4/19 (21%)
		zf-H2C2_2	558..583	CDD:290200	9/24 (38%)
		C2H2 Zn finger	574..594	CDD:275368	9/19 (47%)
		zf-H2C2_2	587..611	CDD:290200	14/23 (61%)
		C2H2 Zn finger	602..622	CDD:275368	8/19 (42%)
		zf-H2C2_2	615..637	CDD:290200	7/50 (14%)
		zf-C2H2	628..650	CDD:278523	7/53 (13%)
		C2H2 Zn finger	630..650	CDD:275368	7/51 (14%)
		C2H2 Zn finger	658..676	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910