DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF652

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001138837.1	Gene:	ZNF652 / 22834	HGNCID:	29147	Length:	606	Species:	Homo sapiens

Alignment Length:	513	Identity:	116/513 - (22%)
Similarity:	213/513 - (41%)	Gaps:	95/513 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SQTHSPNQSQQH----DQQQQAFDSTEEYVMIEM-LNEEQENVANLDEELAEEDRRIFAMTVDEE 164
            |..|:..:.:::    :::::......|.:::|: ||.:..||:..::.::.:.:....:....|
Human    88 SDVHAVKEDRENSDDTEEEEEEVSYKREQIIVEVNLNNQTLNVSKGEKGVSSQSKETPVLKTSSE 152

  Fly   165 EEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESVHEFQ-----PAEVEYVTIKNEFETIVTE 224
            |    ||.:.::|.:::.:...::..|:::...:|.|...|     .|.|...|......|
Human   153 E----EEEESEEEATDDSNDYGENEKQKKKEKIVEKVSVTQRRTRRAASVAAATTSPTPRT---- 209

  Fly   225 EDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEAEDVCEDED--- 286
                    ..|...::                    |..:.:....:|...|..:..||:::
Human   210 --------TRGRRKSV--------------------EPPKRKKRATKEPKAPVQKAKCEEKETLT 246

  Fly   287 ------------FLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECG 339
                        :||:.::     .......:|..|.|.|..:..|:.|.::.. ||..:|..|.
Human   247 CEKCPRVFNTRWYLEKHMN-----VTHRRMQICDKCGKKFVLESELSLHQQTDC-EKNIQCVSCN 305

  Fly   340 KRLKHLRNYKEHM-LTHTNV-KPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFD 402
            |..|.|.:..||: :.|... |...|.||.:.:.|.:.:..|...|.:..|:.|:.||:.:....
Human   306 KSFKKLWSLHEHIKIVHGYAEKKFSCEICEKKFYTMAHVRKHMVAHTKDMPFTCETCGKSFKRSM 370

  Fly   403 HLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVH 467
            .|:.|.|.|:||:|:.|:.||:.:.....||.|...|.|.|.|.|:.||...:.|..:.:||..|
Human   371 SLKVHSLQHSGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTH 435

  Fly   468 SGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKE-----S 527
            :|.|...|::||.:||...|:..|.|.|:||||:.|:||.:.|    |.::.::.|.::     |
Human   436 TGEKPFICEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRF----RFSNMLKAHKEKCFRVTS 496

  Fly   528 PVTATVAVQSINPPSRQAGAEGATGGGATGGSPTGGGATGGSATNLHITEVHEQPVST 585
            ||....|||.   |...:.|........|..:||              ..::..||||
Human   497 PVNVPPAVQI---PLTTSPATPVPSVVNTATTPT--------------PPINMNPVST 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	45/155 (29%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	7/20 (35%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		COG5048	<387..523	CDD:227381	48/135 (36%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
ZNF652	NP_001138837.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..113		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..235		18/140 (13%)
		UFD1	<240..304	CDD:332114	12/69 (17%)
		C2H2 Zn finger	247..266	CDD:275368	2/23 (9%)
		C2H2 Zn finger	274..293	CDD:275368	6/18 (33%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		C2H2 Zn finger	331..351	CDD:275368	5/19 (26%)
		C2H2 Zn finger	359..379	CDD:275368	6/19 (32%)
		SFP1	<381..464	CDD:227516	30/82 (37%)
		C2H2 Zn finger	387..407	CDD:275368	6/19 (32%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		COG5048	439..>488	CDD:227381	19/52 (37%)
		C2H2 Zn finger	443..463	CDD:275368	8/19 (42%)
		C2H2 Zn finger	471..487	CDD:275368	5/19 (26%)
		Mediates interaction with CBFA2T3. /evidence=ECO:0000269\|PubMed:16966434	498..606		13/57 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930