DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp54

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001366288.1	Gene:	Zfp54 / 22712	MGIID:	99201	Length:	625	Species:	Mus musculus

Alignment Length:	231	Identity:	88/231 - (38%)
Similarity:	126/231 - (54%)	Gaps:	2/231 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 TAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQ 362
            ||.|.  |.|..|.|.|.|......|...|..||.|:|.||.:...|...::.|...|:..|.|:
Mouse   334 TAEEC--YSCQYCGKVFHQLSHFKSHFTLHTGEKPYKCNECHRSFPHYVFFRRHKKNHSLQKSHK 396

  Fly   363 CSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYY 427
            |..||:.:...|.|..|.|.|..:|||.|.:|.:.:..:.|||||:..:||::.|.|::|||.:.
Mouse   397 CKECGKSFFILSHLKTHYRIHTGEKPYKCTKCDKLFTQYSHLRRHQRIYTGKKLYRCEVCDKWFT 461

  Fly   428 DSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHV 492
            .||||.:|:..||..|.:.|:.|.:..:..|..::|..||:|.:.:.|..||.:||..|.|..|.
Mouse   462 LSSSLSRHQKIHTEAKTYKCKDCDIFFNHYSSLRRHQKVHTGERHYTCKQCGKSFTRGSTLRVHQ 526

  Fly   493 RLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            |:|:||||:||..|.|:|....:|.:|.|||..|.|
Mouse   527 RIHTGEKPYKCSECDKSFTQASQLRTHQRVHTGEKP 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	56/152 (37%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	54/135 (40%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	4/19 (21%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
Zfp54	NP_001366288.1	KRAB	52..92	CDD:396083
		COG5048	138..544	CDD:227381	80/211 (38%)
		C2H2 Zn finger	225..245	CDD:275368
		C2H2 Zn finger	253..273	CDD:275368
		C2H2 Zn finger	285..305	CDD:275368
		C2H2 Zn finger	313..333	CDD:275368
		C2H2 Zn finger	341..361	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..473	CDD:275368	9/19 (47%)
		C2H2 Zn finger	481..501	CDD:275368	4/19 (21%)
		C2H2 Zn finger	509..529	CDD:275368	9/19 (47%)
		SFP1	<531..611	CDD:227516	16/32 (50%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..585	CDD:275368
		C2H2 Zn finger	593..613	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910