DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp583

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_030098197.1	Gene:	Zfp583 / 213011	MGIID:	2682297	Length:	608	Species:	Mus musculus

Alignment Length:	267	Identity:	97/267 - (36%)
Similarity:	147/267 - (55%)	Gaps:	35/267 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGR 368
            ||.|..|:|||.|...|.||.|.|..|:.:||.||||...:.....:|...||..||:.|.:||:
Mouse   334 PYQCKECKKAFSQIAHLTQHQRIHTGERPFECIECGKAFSNGSFLAQHQRIHTGEKPYVCHVCGK 398

  Fly   369 FYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAY------- 426
            .:.....|.||:|.|..::||.|.:|.:.::.:.||.:|:..||||:||.|.:|.||:
Mouse   399 AFSHRGYLIVHQRIHTGERPYECKECRKSFSQYAHLSQHQRVHTGEKPYECKVCRKAFSQVAYLD 463

  Fly   427 -----------YD----------SSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGV 470
                       |:          ||||.||:.||||:|.:.|:.|....||.:|..:|..:|:|.
Mouse   464 QHQRVHTGEKPYECAECRKAFSNSSSLAQHQRSHTGEKPYICKECRKTFSQNAGLAQHQRIHTGE 528

  Fly   471 KAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAV 535
            |.::|::||.||:::.:|..|.|:|:||:|::|:.|.|:|..:..||.|.:||..||       .
Mouse   529 KPYECNICGKAFSYSGSLTLHQRIHTGERPYECKDCRKSFRQRAHLAHHEKVHTMES-------F 586

  Fly   536 QSINPPS 542
            .|::.||
Mouse   587 LSLSSPS 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	63/174 (36%)
		C2H2 Zn finger	307..327	CDD:275368	10/19 (53%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	57/163 (35%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	11/47 (23%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	10/22 (45%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
Zfp583	XP_030098197.1	KRAB	45..106	CDD:214630
		COG5048	240..581	CDD:227381	90/246 (37%)
		C2H2 Zn finger	253..273	CDD:275368
		C2H2 Zn finger	281..301	CDD:275368
		C2H2 Zn finger	309..329	CDD:275368
		C2H2 Zn finger	337..357	CDD:275368	10/19 (53%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	421..441	CDD:275368	5/19 (26%)
		C2H2 Zn finger	449..469	CDD:275368	4/19 (21%)
		C2H2 Zn finger	477..497	CDD:275368	6/19 (32%)
		C2H2 Zn finger	505..525	CDD:275368	6/19 (32%)
		C2H2 Zn finger	533..553	CDD:275368	8/19 (42%)
		C2H2 Zn finger	561..581	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000