DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp658

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001008549.1	Gene:	Zfp658 / 210104	MGIID:	2652821	Length:	887	Species:	Mus musculus

Alignment Length:	668	Identity:	170/668 - (25%)
Similarity:	251/668 - (37%)	Gaps:	212/668 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LNCRT--CTRACKLHKPLQEEIDLGSEGSTT--LASMLNYCTGLSFEPQDGAAMPQHICLHCLQL 72
            ||.:|  ..|.|...:|          |.||  :|::        |..|.||  |:.:.......
Mouse   159 LNKKTARADRDCGWKEP----------GKTTPFVANL--------FSTQKGA--PRLLAKRLNPN 203

  Fly    73 L-----EQAFNFKRM--VIDSDELLRLGLDEARCSSFHESQTHSP---NQSQQHDQQQQAFDSTE 127
            |     ||....|::  ::.|..||......|.|:...|  |.:|   ||.::....:|
Mouse   204 LEANGEEQGSVTKQLNGLVTSAHLLPQDSSNANCTILRE--TWNPCKGNQCRKVPTHKQ------ 260

  Fly   128 EYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGD-- 190
                  :..:|..:...|||  ..|.|::|.                 ||.:..:||.|.:|:
Mouse   261 ------LTEKEAHSREKLDE--GTECRKVFY-----------------DESAFCKHQAAHAGEGP 300

  Fly   191 -----------QQEEHITMESVHEFQPAEV-----EYVTIKN--EFETIVTEEDEFEVMNDSGAH 237
                       |:.|..:.:..|..:|.|.     .:....|  ....|.|.|..:|..
Mouse   301 FVCHKCGEAFLQKTEFASHQETHPEKPYECPDCGKSFSRTSNLQVHHRIHTGEKPYECR------ 359

  Fly   238 DAILDCQMIVIPAEGAIDEVIGE---ETLELE-----GDGREEHLLPEAEDVCEDEDFLEESLDS 294
                ||               |:   .|.:|:     ..|...::.|    || .:.|.::|:.|
Mouse   360 ----DC---------------GKSFNNTSQLKVHYRIHTGERPYVCP----VC-GKAFKQKSILS 400

  Fly   295 APPT--AGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLK-----------HLR 346
            ...|  .||. ||.||||.|.|....||..|.:.|:.||.|||.:|||..|           |:|
Mouse   401 THETIHTGEK-PYKCTVCGKLFSCTSRLKVHYQIHMKEKPYECGDCGKAFKRKSSLTVHQKIHIR 464

  Fly   347 ---------------------------------------------NYKEHMLTHTNVKPHQCSIC 366
                                                         ..|.|...||..||::|..|
Mouse   465 QTHHECSECGKTFNQKSELSTHQRLHLGKNSHRCSDCGKSFTYASQLKMHRRVHTGEKPYKCRDC 529

  Fly   367 GRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSS 431
            |:.:..:.:|.||:|.|..:||:.|..||:..|:...|..|:..||||:||.|..|.|.::..|.
Mouse   530 GKSFTYSFTLNVHRRIHKVEKPHKCSICGKALASKYQLEEHERIHTGEKPYVCTECGKGFHGRSG 594

  Fly   432 LRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHS 496
            ..:|:|:||..|.|.|..||....|:|....|...|:|.|.:.|..||.:|:.||.|..|.|:|:
Mouse   595 FLRHQITHTRDKPFVCHKCGKAFFQRSQLTSHQQTHTGEKPYTCHYCGKSFSHTSQLTVHHRIHT 659

  Fly   497 GEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQSINPPSRQAGAEGATGGGATGGSPT 561
            ||:|:||:.|.|:|....:|..|:|:|..|:|...                           |..
Mouse   660 GERPYKCDYCAKSFSNSSQLKEHLRIHTGETPYAC---------------------------SEC 697

  Fly   562 GGGATGGSATNLHITEVH 579
            |...:..|:.||| |::|
Mouse   698 GKAFSRRSSLNLH-TKIH 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	19/87 (22%)
		COG5048	<297..451	CDD:227381	65/211 (31%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	9/75 (12%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	54/135 (40%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
Zfp658	NP_001008549.1	KRAB	23..80	CDD:214630
		C2H2 Zn finger	275..295	CDD:275368	7/36 (19%)
		COG5048	300..684	CDD:227381	115/414 (28%)
		C2H2 Zn finger	303..323	CDD:275368	2/19 (11%)
		C2H2 Zn finger	330..350	CDD:275368	1/19 (5%)
		C2H2 Zn finger	358..378	CDD:275368	5/44 (11%)
		C2H2 Zn finger	386..406	CDD:275368	7/24 (29%)
		C2H2 Zn finger	414..434	CDD:275368	9/19 (47%)
		C2H2 Zn finger	442..462	CDD:275368	5/19 (26%)
		C2H2 Zn finger	470..490	CDD:275368	0/19 (0%)
		COG5048	493..887	CDD:227381	79/250 (32%)
		C2H2 Zn finger	498..518	CDD:275368	2/19 (11%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		C2H2 Zn finger	554..574	CDD:275368	6/19 (32%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)
		C2H2 Zn finger	610..630	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..658	CDD:275368	9/19 (47%)
		C2H2 Zn finger	666..686	CDD:275368	7/19 (37%)
		C2H2 Zn finger	694..714	CDD:275368	7/47 (15%)
		C2H2 Zn finger	722..742	CDD:275368
		C2H2 Zn finger	750..770	CDD:275368
		C2H2 Zn finger	778..798	CDD:275368
		C2H2 Zn finger	806..826	CDD:275368
		C2H2 Zn finger	834..854	CDD:275368
		C2H2 Zn finger	862..882	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910