DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF626

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001070143.1	Gene:	ZNF626 / 199777	HGNCID:	30461	Length:	528	Species:	Homo sapiens

Alignment Length:	518	Identity:	142/518 - (27%)
Similarity:	214/518 - (41%)	Gaps:	145/518 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 HCLQLLEQAFNFKRMVIDSDELLRLG-----------LDEAR-----------------CSSFHE 104
            |||...::......|:.:...|:.||           |::.|                 ||  |.
Human    19 HCLDTAQRNLYRNVMLENYSNLVFLGITVSKPDLITCLEQGRKPLTMKRNEMIAKPSVMCS--HF 81

  Fly   105 SQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLT 169
            :|...|.||.:        ||.::.|:......|.:|:......::.::.::.....:|..:.||
Human    82 AQDLWPEQSMK--------DSFQKVVLRRYEKCEHDNLQLKKGCISVDECKVHKEGYNELNQCLT 138

  Fly   170 ---EEVDQDDELSEEEHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVM 231
               .::.|.|:..:..||...|..|:..| |.:...::    :|......:|.|:.|
Human   139 TTPRKICQCDKYVKVLHQFPNSNGQKRGH-TGKKPFKY----IECGKAFKQFSTLTT-------- 190

  Fly   232 NDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAP 296
                 |..|                                |
Human   191 -----HKKI--------------------------------H----------------------- 195

  Fly   297 PTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPH 361
             |.|:  ||.|..|.|||...|.|.:|.:.|..||.|:||||||..||......|...||..||:
Human   196 -TGGK--PYKCEECGKAFNHSCSLTRHKKIHTGEKPYKCEECGKAFKHSSTLTTHKRNHTGEKPY 257

  Fly   362 QCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAY 426
            :|..||:.:.::|:|:.|:..|.|||||.|::||:.:.....|..||:.||||:||.|:.||||:
Human   258 KCDKCGKAFMSSSTLSKHEIIHTEKKPYKCEECGKAFNRSSTLTTHKIIHTGEKPYKCEECDKAF 322

  Fly   427 -YD---------------------------SSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKH 463
             |.                           ||:|..||..|||:|.:.||.||....:.|....|
Human   323 KYSYTLTTHKRIHTEDKPYKCEECGKAFKYSSTLTTHKRIHTGEKPYKCEECGKAFKRSSDLTTH 387

  Fly   464 MMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKE 526
            .::|:|.|.:||:.||.||.::|||..|.::|:||:|:|||.|.|||.....|.:|.|:|..|
Human   388 KIIHTGEKPYKCEECGKAFKYSSNLTTHKKIHTGERPYKCEECGKAFNQSSILTTHRRIHTGE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	5/22 (23%)
		COG5048	<297..451	CDD:227381	70/181 (39%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	63/163 (39%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	419..439	CDD:275368	11/47 (23%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
ZNF626	NP_001070143.1	KRAB	4..62	CDD:214630	9/42 (21%)
		KRAB	6..43	CDD:279668	5/23 (22%)
		C2H2 Zn finger	177..195	CDD:275368	6/62 (10%)
		zf-H2C2_2	188..212	CDD:290200	13/94 (14%)
		COG5048	199..520	CDD:227381	101/254 (40%)
		C2H2 Zn finger	203..223	CDD:275368	8/19 (42%)
		zf-H2C2_2	215..240	CDD:290200	12/24 (50%)
		C2H2 Zn finger	231..251	CDD:275368	9/19 (47%)
		zf-H2C2_2	244..266	CDD:290200	8/21 (38%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..296	CDD:290200	11/23 (48%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		zf-H2C2_2	300..324	CDD:290200	14/23 (61%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..352	CDD:290200	0/23 (0%)
		C2H2 Zn finger	343..363	CDD:275368	5/19 (26%)
		zf-H2C2_2	356..380	CDD:290200	11/23 (48%)
		C2H2 Zn finger	371..391	CDD:275368	6/19 (32%)
		zf-H2C2_2	383..408	CDD:290200	10/24 (42%)
		C2H2 Zn finger	399..419	CDD:275368	9/19 (47%)
		zf-H2C2_2	411..436	CDD:290200	14/24 (58%)
		C2H2 Zn finger	427..447	CDD:275368	9/19 (47%)
		zf-H2C2_2	440..464	CDD:290200	5/11 (45%)
		C2H2 Zn finger	455..475	CDD:275368
		zf-H2C2_2	467..492	CDD:290200
		C2H2 Zn finger	483..502	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010