DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dwg and ZNF778

DIOPT Version :9

Sequence 1:NP_477338.3 Gene:dwg / 31265 FlyBaseID:FBgn0000520 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_001188336.1 Gene:ZNF778 / 197320 HGNCID:26479 Length:757 Species:Homo sapiens


Alignment Length:225 Identity:97/225 - (43%)
Similarity:133/225 - (59%) Gaps:0/225 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly   304 PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGR 368
            ||.|:.|.|||..:|.|.:|:|:|..||.|.|::|||.........||:.|||..||::|..||:
Human   420 PYTCSYCGKAFTVRCGLTRHVRTHTGEKPYTCKDCGKAFCTSSGLTEHVRTHTGEKPYECKDCGK 484

  Fly   369 FYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLR 433
            .:..:|||..|.|.|..:|||.|.|||:.:.....|.:|..|||||:||.|..|.|||.....|.
Human   485 SFTVSSSLTEHARIHTGEKPYECKQCGKAFTGRSGLTKHMRTHTGEKPYECKDCGKAYNRVYLLN 549

  Fly   434 QHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGE 498
            :|..:||.:|.|.|.:|.......|...||:.:|:|:|.::|..||..||.:|:|..|:|.|:||
Human   550 EHVKTHTEEKPFICTVCRKSFRNSSCLNKHIQIHTGIKPYECKDCGKTFTVSSSLTEHIRTHTGE 614

  Fly   499 KPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            ||::|:||.|||.|...|..|:|.|..|.|
Human   615 KPYECKVCGKAFTTSSHLIVHIRTHTGEKP 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dwgNP_477338.3 zf-AD 14..91 CDD:214871
COG5048 <297..451 CDD:227381 63/146 (43%)
C2H2 Zn finger 307..327 CDD:275368 9/19 (47%)
C2H2 Zn finger 335..355 CDD:275368 6/19 (32%)
C2H2 Zn finger 363..383 CDD:275368 8/19 (42%)
COG5048 <387..523 CDD:227381 59/135 (44%)
C2H2 Zn finger 391..411 CDD:275368 6/19 (32%)
zf-H2C2_2 403..426 CDD:290200 12/22 (55%)
C2H2 Zn finger 419..439 CDD:275368 7/19 (37%)
C2H2 Zn finger 447..467 CDD:275368 5/19 (26%)
C2H2 Zn finger 475..495 CDD:275368 9/19 (47%)
zf-H2C2_2 487..510 CDD:290200 12/22 (55%)
C2H2 Zn finger 503..523 CDD:275368 10/19 (53%)
ZNF778NP_001188336.1 KRAB 42..100 CDD:214630
C2H2 Zn finger 283..303 CDD:275368
C2H2 Zn finger 311..331 CDD:275368
C2H2 Zn finger 339..358 CDD:275368
C2H2 Zn finger 367..387 CDD:275368
COG5048 380..747 CDD:227381 97/225 (43%)
C2H2 Zn finger 395..415 CDD:275368
C2H2 Zn finger 423..443 CDD:275368 9/19 (47%)
C2H2 Zn finger 451..471 CDD:275368 6/19 (32%)
C2H2 Zn finger 479..499 CDD:275368 8/19 (42%)
C2H2 Zn finger 507..527 CDD:275368 6/19 (32%)
C2H2 Zn finger 535..555 CDD:275368 7/19 (37%)
C2H2 Zn finger 563..583 CDD:275368 5/19 (26%)
C2H2 Zn finger 591..611 CDD:275368 9/19 (47%)
C2H2 Zn finger 619..639 CDD:275368 10/19 (53%)
C2H2 Zn finger 647..667 CDD:275368
C2H2 Zn finger 675..695 CDD:275368
C2H2 Zn finger 703..722 CDD:275368
C2H2 Zn finger 731..751 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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