DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and zag-1

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_500424.3	Gene:	zag-1 / 177144	WormBaseID:	WBGene00006970	Length:	596	Species:	Caenorhabditis elegans

Alignment Length:	724	Identity:	144/724 - (19%)
Similarity:	213/724 - (29%)	Gaps:	342/724 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IDLGSEGSTTLASMLNYCTGLSFEPQDGAAMPQHICLHCLQLLEQAFNFKRMVIDSDELLRL--G 93
            :|:.....||.:|:          |.| .|:.:..|..|    .:||.||..:   .|.:|:  |
Worm     2 VDIAEAMPTTASSL----------PSD-EALRKFKCPEC----TKAFKFKHHL---KEHIRIHSG 48

  Fly    94 LDEARCSSFHESQTHSPNQSQQHDQQ---QQAFDSTEEYVMIEMLNEEQ----ENV--------- 142
            .....|...|:..:||.:.|.....:   |||..|     |:...|..|    .|:
Worm    49 EKPFECQQCHKRFSHSGSYSSHMSSKKCVQQASPS-----MVTPFNPYQLMMYRNIMLQLQTPQV 108

  Fly   143 ------------------ANLDEEL---------------AEEDRRIFAMTVDEEE---EFLTE- 170
                              |||.:.|               |..:.:|  ..|||.|   |..||
Worm   109 SFLPSTAANNMDYMSLLQANLFQSLENGTSPTPTQEPSAPASPEPKI--EVVDEPEVSSEVKTEV 171

  Fly   171 --EVDQDDELSEEEHQLAQS-----GDQQEEHITM---------ESVHEFQPA-------EVEYV 212
              ||..:|.:.||....|.|     ..:|..:.:|         :|..:::|.       :.:..
Worm   172 KTEVKTEDSVPEESITPAVSMSLSPAPEQNGNESMNNGGSGSDGKSSPDWRPLRSRSFLNDSQVA 236

  Fly   213 TIKNEFE---------------------------------------------------------- 219
            .::|.|:
Worm   237 VLQNHFKRNPFPSKYELSAVAEQIGVNKRVVQVWFQNTRAKERRSNRLPSMPRGSVASAAAAAAT 301

  Fly   220 ------------------------TIVTEEDE------FEVMNDSGAHD---AILDCQMIVIPAE 251
                                    ::...:||      .|||:..|..|   ..||..:.....|
Worm   302 SPTVWQTPVQLMAAWASQFSNGNNSLTASQDERNNENTDEVMDHDGLKDGKETPLDLTLSTDDTE 366

  Fly   252 ---------GAIDEVIG--EETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEA--- 302
                     |.:|:..|  :|.|...|:|    .:...||..|.....|||    |.::|.:
Worm   367 PEWSPEKLIGFLDQTGGVIQELLRQAGNG----FVTNQEDEEEKPIKAEES----PVSSGSSSIW 423

  Fly   303 ------LPYV-----CTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHT 356
                  .|.:     .:|.:||..||       :|..|:....|....|.||
Worm   424 PSFIGQYPSILDSASLSVLEKALDQQ-------KSSEDDASSLCSNESKLLK------------- 468

  Fly   357 NVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDL 421
                         :.||.       ...|:..::||||.:.:.....|.|||..|:|:|||.||:
Worm   469 -------------FPTTP-------LKEEEGLFSCDQCDKVFGKQSSLARHKYEHSGQRPYKCDI 513

  Fly   422 CDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTS 486
            |:||:                                   ||       |.|
Worm   514 CEKAF-----------------------------------KH-------KHH------------- 523

  Fly   487 NLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHN-------KESPV---------TATVAV 535
             |..|.|||||||||:|:.|:|.|......:.||. |.       :|.|.         :.||:.
Worm   524 -LTEHKRLHSGEKPFQCDKCLKRFSHSGSYSQHMN-HRYSYCKPYREQPASPSDVLNGGSVTVSP 586

  Fly   536 QSIN--PPS 542
            .|.|  |||
Worm   587 SSSNTPPPS 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	14/59 (24%)
		COG5048	<297..451	CDD:227381	34/167 (20%)
		C2H2 Zn finger	307..327	CDD:275368	5/19 (26%)
		C2H2 Zn finger	335..355	CDD:275368	4/19 (21%)
		C2H2 Zn finger	363..383	CDD:275368	2/19 (11%)
		COG5048	<387..523	CDD:227381	39/135 (29%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	2/19 (11%)
		C2H2 Zn finger	475..495	CDD:275368	3/19 (16%)
		zf-H2C2_2	487..510	CDD:290200	14/22 (64%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
zag-1	NP_500424.3	zf-C2H2	24..46	CDD:278523	8/28 (29%)
		C2H2 Zn finger	26..46	CDD:275368	8/26 (31%)
		zf-H2C2_2	38..61	CDD:290200	5/25 (20%)
		homeodomain	225..282	CDD:238039	2/56 (4%)
		C2H2 Zn finger	483..503	CDD:275368	8/19 (42%)
		zf-H2C2_2	495..520	CDD:290200	14/59 (24%)
		COG5048	506..>559	CDD:227381	29/109 (27%)
		C2H2 Zn finger	511..531	CDD:275368	12/75 (16%)
		zf-H2C2_2	523..548	CDD:290200	16/38 (42%)
		C2H2 Zn finger	539..556	CDD:275368	4/16 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I3383
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050