DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and R10E4.11

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001254910.1	Gene:	R10E4.11 / 175554	WormBaseID:	WBGene00011206	Length:	386	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	74/358 - (20%)
Similarity:	137/358 - (38%)	Gaps:	84/358 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 RRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQ-----QEEHITMESVHEFQPAEVEYVT 213
            ||.|.:....:.|:......:.|.:..|..:..:..|.     .|..|:|..|...|.||..
Worm     8 RRSFRLKDKPKPEYAFNNFLKKDYVHPEVVETNKKYDDIFSSVMENAISMHVVMTQQRAEKR--- 69

  Fly   214 IKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGA-----IDEVIGEETLELEGDGREE- 272
                      .....|..:||...|::.|      .::||     ::|:  :|.|::.|..|.:
Worm    70 ----------RHGGSEESSDSEDSDSVAD------DSDGATHGSRLEEM--QERLKILGSKRSKP 116

  Fly   273 -------HLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHM-RSHVD 329
                   .::|:.|:..|:||...:.|.|.|..      |.|: |.|..:.....::|: ..|.|
Worm   117 EIPIKDLEVVPKLEEEAEEEDMDIQILPSPPKM------YACS-CGKRLKTHSDCHKHIFDEHGD 174

  Fly   330 -EKQYECEECGKRLKHLR-------------NYKEHMLTH--TNVKPH---QCSICGRFYRTTSS 375
             :.:.:|.|||.||..:|             |.:||..:|  |:...|   :|..|.|.:||...
Worm   175 HDIKADCLECGNRLNDIRTNNQCSVCKSYAENVEEHEKSHYRTSTSKHAVMECRYCVRQFRTVKE 239

  Fly   376 LAVHKRTHAEKKP------YNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQ 434
            :..|::.....||      :.|::|...:.:.:.|..|...|. :.....|..::..|...:|::
Worm   240 VIEHEKEKHLAKPLRKTQFFKCNECSVVFTSQEVLTGHYGDHV-DLNLLNDKIEELQYQIEALKE 303

  Fly   435 HKISHTGKKAFTCEICGVGLSQKSGYKKHMMVH 467
            .           |..|.:.::.:..::.|::.|
Worm   304 E-----------CPFCRIFMASRKSFRAHLLKH 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	37/179 (21%)
		C2H2 Zn finger	307..327	CDD:275368	4/20 (20%)
		C2H2 Zn finger	335..355	CDD:275368	10/32 (31%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	14/87 (16%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		zf-H2C2_2	403..426	CDD:290200	4/22 (18%)
		C2H2 Zn finger	419..439	CDD:275368	3/19 (16%)
		C2H2 Zn finger	447..467	CDD:275368	3/19 (16%)
		C2H2 Zn finger	475..495	CDD:275368
		zf-H2C2_2	487..510	CDD:290200
		C2H2 Zn finger	503..523	CDD:275368
R10E4.11	NP_001254910.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910