DRSC/TRiP Functional Genomics Resources

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Protein Alignment dwg and egl-43

DIOPT Version :9

Sequence 1:NP_477338.3 Gene:dwg / 31265 FlyBaseID:FBgn0000520 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_001022288.1 Gene:egl-43 / 174552 WormBaseID:WBGene00001207 Length:543 Species:Caenorhabditis elegans


Alignment Length:594 Identity:109/594 - (18%)
Similarity:187/594 - (31%) Gaps:235/594 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   159 MTVDEEEEFLTEEVDQDDELSEEEH--------QLAQSGDQQEEHITMESVHEFQPAEVEYVTIK 215
            |::|  .:|||....::|||    |        |:|...       |:..:.:..|.:...:.|.
 Worm     1 MSID--TDFLTSVEVKEDEL----HGNVLIAVTQIALGR-------TIGVIDKATPNDSNALLIL 52

  Fly   216 NEFETIVTEEDEFEVMNDSGAHD---AILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPE 277
            |    ::.|.|:.|..|.....:   ..|....|:         .|||..|          |...
 Worm    53 N----LIKEADDGEDANICMRQEDRKTFLQTSKII---------NIGERLL----------LQRL 94

  Fly   278 AEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLN---QHMRSHVD--------EK 331
            :|:.|::||  ::.|::......|..|.....|.|:..:...||   :::|.|.:        :.
 Worm    95 SEEECDEED--QDDLENLILLKDEDRPDSTQSCTKSSSEDSNLNGFEEYIREHGELVPGQTPPDG 157

  Fly   332 QYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGR 396
            .::|..|.|........|:|...|.::||.:|.:|.:.|...|:|..|:|.|::  .:.|..|..
 Worm   158 SHKCGVCPKSFSSASGLKQHSHIHCSLKPFRCHLCPKSYTQFSNLCRHRRVHSD--GWTCPTCQS 220

  Fly   397 GYAAFDHLRRHK----------------------------------------------------- 408
            ...:...|.:|:                                                     
 Worm   221 QMPSQAALTKHRPVCEMTALYKPLMAQLAGLSGAGGLGSVPYWPHILQMATQAPHFPLAFLAANP 285

  Fly   409 -----------------------------------LTHTGERPYACDLCDKAYYD---------- 428
                                               ||.|.:.|...::...:..|          
 Worm   286 EAYKLMQQTTCASPDAECSSGHASESSPTTTEPVDLTATPKPPSTSEMETTSKSDDGEDRDSIGD 350

  Fly   429 -------------------SSSLRQHKISHT----------GKKAFTCEICGVGLSQKSGYK--- 461
                               ::|.::...|||          |.:|......|: |.:...|.   
 Worm   351 SGNDDDDDSEAGVLDESSTTTSTKKRPTSHTISDILAAPQLGAQALNSTFLGM-LQRSLNYNPAV 414

  Fly   462 ----KHMMVHSGVKA--------------HKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVK 508
                ..:...||.||              :.|..|...|..::||..|:|.|:||:|:||:.|.:
 Worm   415 PSPHSFLRAMSGAKASSSPSSSSGSGKDRYTCKFCQKVFPRSANLTRHLRTHTGEQPYKCQYCER 479

  Fly   509 AFPTKKRLASHMR-VHNKESPVTATVAVQSINPPS--RQAGAEGATGGGATGGSPTGGGATGGSA 570
            :|.....|..|:| :|||  |.|      |:.|.:  ||.....:|             :|..:.
 Worm   480 SFSISSNLQRHVRNIHNK--PNT------SLTPHNHHRQRSLHNST-------------STSTTT 523

  Fly   571 TNLHITEVH 579
            |.:|...:|
 Worm   524 TTVHHPLLH 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dwgNP_477338.3 zf-AD 14..91 CDD:214871
COG5048 <297..451 CDD:227381 39/291 (13%)
C2H2 Zn finger 307..327 CDD:275368 5/22 (23%)
C2H2 Zn finger 335..355 CDD:275368 5/19 (26%)
C2H2 Zn finger 363..383 CDD:275368 7/19 (37%)
COG5048 <387..523 CDD:227381 40/284 (14%)
C2H2 Zn finger 391..411 CDD:275368 5/107 (5%)
zf-H2C2_2 403..426 CDD:290200 6/110 (5%)
C2H2 Zn finger 419..439 CDD:275368 2/48 (4%)
C2H2 Zn finger 447..467 CDD:275368 3/26 (12%)
C2H2 Zn finger 475..495 CDD:275368 7/19 (37%)
zf-H2C2_2 487..510 CDD:290200 11/22 (50%)
C2H2 Zn finger 503..523 CDD:275368 6/20 (30%)
egl-43NP_001022288.1 SFP1 <115..210 CDD:227516 23/94 (24%)
C2H2 Zn finger 161..181 CDD:275368 5/19 (26%)
C2H2 Zn finger 189..209 CDD:275368 7/19 (37%)
C2H2 Zn finger 215..232 CDD:275368 3/16 (19%)
zf-C2H2 444..466 CDD:395048 7/21 (33%)
C2H2 Zn finger 446..466 CDD:275368 7/19 (37%)
zf-H2C2_2 458..482 CDD:404364 11/23 (48%)
C2H2 Zn finger 474..495 CDD:275368 6/20 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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