DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF431

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_011526052.1	Gene:	ZNF431 / 170959	HGNCID:	20809	Length:	593	Species:	Homo sapiens

Alignment Length:	466	Identity:	135/466 - (28%)
Similarity:	211/466 - (45%)	Gaps:	78/466 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIE-MLN 136
            |::...|:      |..:...|:|..|.          |.:||:.......::.:..|.:. :..
Human    47 LQETLTFR------DVAIEFSLEEWECL----------NPAQQNLYMNVMLENYKNLVFLAGVAV 95

  Fly   137 EEQENVANLDEELAEEDRRIFAMTVDEEE---EFLTEEV--DQDDELSEEEHQLAQSGDQQEEHI 196
            .:|:.|..|::|....:.:...| |||..   .:.|:::  :||.:.|.::..|.:.|..:.|::
Human    96 SKQDPVTCLEQEKEPWNMKRHEM-VDEPPAMCSYFTKDLWPEQDIKDSFQQVILRRYGKCEHENL 159

  Fly   197 TME----SVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEV 257
            .:.    ||.|::..:..|    ||....:|.           ....|..|...|        :|
Human   160 QLRKGSASVDEYKVHKEGY----NELNQCLTT-----------TQSKIFPCDKYV--------KV 201

  Fly   258 IGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQ 322
            .                          ..||..:......|..:  |:.|..|.|:|.....|:|
Human   202 F--------------------------HKFLNANRHKTRHTGKK--PFKCKKCGKSFCMLLHLSQ 238

  Fly   323 HMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKK 387
            |.|.|:.|..|:||||||..|.......|...||..||.:|..||:.::.:|:|..||..|..:|
Human   239 HKRIHIRENSYQCEECGKAFKWFSTLTRHKRIHTGEKPFKCEECGKAFKQSSTLTTHKIIHTGEK 303

  Fly   388 PYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGV 452
            ||.|::||:.:....||..||:.||||:||.|:.|.||:..||:|..||..|.|:|.:.||.|..
Human   304 PYRCEECGKAFNRSSHLTTHKIIHTGEKPYKCEECGKAFNQSSTLSTHKFIHAGEKPYKCEECDK 368

  Fly   453 GLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLA 517
            ..::.|...||.::|:|.|::||:.||..|.::|.|..|.|:|:||||:|||||.|||.....|.
Human   369 AFNRFSYLTKHKIIHTGEKSYKCEECGKGFNWSSTLTKHKRIHTGEKPYKCEVCGKAFNESSNLT 433

  Fly   518 SHMRVHNKESP 528
            :|..:|..|.|
Human   434 THKMIHTGEKP 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	3/17 (18%)
		COG5048	<297..451	CDD:227381	63/153 (41%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	61/135 (45%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	14/22 (64%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
ZNF431	XP_011526052.1	KRAB	51..112	CDD:214630	13/76 (17%)
		KRAB	51..90	CDD:279668	9/54 (17%)
		zf-H2C2_2	209..230	CDD:290200	5/22 (23%)
		COG5048	218..570	CDD:227381	96/229 (42%)
		C2H2 Zn finger	223..243	CDD:275368	8/19 (42%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		zf-H2C2_2	264..288	CDD:290200	8/23 (35%)
		C2H2 Zn finger	279..299	CDD:275368	7/19 (37%)
		zf-H2C2_2	292..316	CDD:290200	10/23 (43%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		zf-H2C2_2	319..344	CDD:290200	14/24 (58%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	9/23 (39%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		zf-H2C2_2	404..427	CDD:290200	15/22 (68%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		zf-H2C2_2	431..456	CDD:290200	5/14 (36%)
		C2H2 Zn finger	447..467	CDD:275368
		zf-H2C2_2	460..484	CDD:290200
		C2H2 Zn finger	475..495	CDD:275368
		zf-H2C2_2	488..512	CDD:290200
		C2H2 Zn finger	503..523	CDD:275368
		zf-H2C2_2	515..540	CDD:290200
		C2H2 Zn finger	531..551	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010