DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dwg and ZNF679

DIOPT Version :9

Sequence 1:NP_477338.3 Gene:dwg / 31265 FlyBaseID:FBgn0000520 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_699194.2 Gene:ZNF679 / 168417 HGNCID:28650 Length:411 Species:Homo sapiens


Alignment Length:224 Identity:98/224 - (43%)
Similarity:134/224 - (59%) Gaps:0/224 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly   305 YVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRF 369
            :.|....|:|....:|:||...|..|..|:||||||.........:|...||..||::|..||:.
Human   184 FKCKKYGKSFCMVSQLHQHQIIHTRENSYQCEECGKPFNCSSTLSKHKRIHTGEKPYRCEECGKA 248

  Fly   370 YRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQ 434
            :..:|:|..|:|.|..:|||.|::||:.::....|..||..||||:||.|:.|.||:..||||..
Human   249 FTWSSTLTKHRRIHTGEKPYTCEECGQAFSRSSTLANHKRIHTGEKPYTCEECGKAFSLSSSLTY 313

  Fly   435 HKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEK 499
            ||..|||:|.:|||.||...:..|..|||.::|:|.|.:||..||.||.|:|.||.|.|:|:||:
Human   314 HKRIHTGEKPYTCEECGKAFNCSSTLKKHKIIHTGEKPYKCKECGKAFAFSSTLNTHKRIHTGEE 378

  Fly   500 PFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            |:|||.|.|||.....||:|..:|..|.|
Human   379 PYKCEECDKAFKWSSSLANHKSMHTGEKP 407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dwgNP_477338.3 zf-AD 14..91 CDD:214871
COG5048 <297..451 CDD:227381 60/145 (41%)
C2H2 Zn finger 307..327 CDD:275368 6/19 (32%)
C2H2 Zn finger 335..355 CDD:275368 7/19 (37%)
C2H2 Zn finger 363..383 CDD:275368 7/19 (37%)
COG5048 <387..523 CDD:227381 67/135 (50%)
C2H2 Zn finger 391..411 CDD:275368 6/19 (32%)
zf-H2C2_2 403..426 CDD:290200 12/22 (55%)
C2H2 Zn finger 419..439 CDD:275368 10/19 (53%)
C2H2 Zn finger 447..467 CDD:275368 8/19 (42%)
C2H2 Zn finger 475..495 CDD:275368 11/19 (58%)
zf-H2C2_2 487..510 CDD:290200 13/22 (59%)
C2H2 Zn finger 503..523 CDD:275368 9/19 (47%)
ZNF679NP_699194.2 KRAB 16..76 CDD:214630
KRAB 16..55 CDD:279668
C2H2 Zn finger 159..178 CDD:275368
C2H2 Zn finger 186..206 CDD:275368 6/19 (32%)
C2H2 Zn finger 214..234 CDD:275368 7/19 (37%)
zf-H2C2_2 227..250 CDD:290200 8/22 (36%)
COG5048 <238..401 CDD:227381 77/162 (48%)
C2H2 Zn finger 242..262 CDD:275368 7/19 (37%)
zf-H2C2_2 255..279 CDD:290200 10/23 (43%)
C2H2 Zn finger 270..290 CDD:275368 6/19 (32%)
zf-H2C2_2 283..306 CDD:290200 13/22 (59%)
C2H2 Zn finger 298..318 CDD:275368 10/19 (53%)
zf-H2C2_2 310..335 CDD:290200 13/24 (54%)
C2H2 Zn finger 326..346 CDD:275368 8/19 (42%)
zf-H2C2_2 339..362 CDD:290200 11/22 (50%)
C2H2 Zn finger 354..374 CDD:275368 11/19 (58%)
zf-H2C2_2 367..390 CDD:290200 14/22 (64%)
C2H2 Zn finger 382..402 CDD:275368 9/19 (47%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24384
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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