DRSC/TRiP Functional Genomics Resources

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Protein Alignment dwg and ZNF114

DIOPT Version :9

Sequence 1:NP_477338.3 Gene:dwg / 31265 FlyBaseID:FBgn0000520 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_001318027.1 Gene:ZNF114 / 163071 HGNCID:12894 Length:463 Species:Homo sapiens


Alignment Length:566 Identity:124/566 - (21%)
Similarity:200/566 - (35%) Gaps:166/566 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 MNSKIAEVVVLNCRTCTRA-CKLHKPLQEEIDLGSEGSTTLASMLNYCTGLSFEPQDGAAMPQHI 65
            |:..:|.:..|:|.....| |.||.|       ||....:.||.:...||.....:|.       
Human     1 MSQGLALLPRLDCSGRIIAYCNLHLP-------GSGNPPSSASRVAETTGTRPHSRDS------- 51

  Fly    66 CLHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYV 130
                :...:.|.||.:                                    ::....|..:..:
Human    52 ----VTFADVAVNFTK------------------------------------EEWTLLDPAQRNL 76

  Fly   131 MIEMLNEEQENVANLD------------------EELAEEDRRIFAMTVDEEEEFLTEEVDQDDE 177
            ..:::.|...|:|.:|                  :....|..|:...::..:...|.|  |....
Human    77 YRDVMLENSRNLAFIDWATPCKTKDATPQPDILPKRTFPEANRVCLTSISSQHSTLRE--DWRCP 139

  Fly   178 LSEEEHQL--------AQSGDQQEEHITMESVHEFQ----------PAEVEYVTIKNEFETIVTE 224
            .:||.|:.        |.:.::.|..:::...||.:          |::.:.:.     :.|:|.
Human   140 KTEEPHRQGVNNVKPPAVAPEKDESPVSICEDHEMRNHSKPTCRLVPSQGDSIR-----QCILTR 199

  Fly   225 EDEF----EVMNDS------GAHDAILDCQMIVIPAEGAIDEVIGEETLELE-----GDGREEHL 274
            :...    .|:|||      ...|.:|...:..:|.        |.:| ||:     |.....| 
Human   200 DSSIFKYNPVLNDSQKTHENNEDDGVLGWNIQWVPC--------GRKT-ELKSSTWTGSQNTVH- 254

  Fly   275 LPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECG 339
                        .:.:.:|:. ....:..|:     .||||:...|..| .:|..||.|:..:|.
Human   255 ------------HIRDEIDTG-ANRHQRNPF-----GKAFREDGSLRAH-NTHGREKMYDFTQCE 300

  Fly   340 KRLKHLRNYKEHML------THTNVKPHQCSICGRFYRTTSSLAVHKRTHAE----KKPYNCDQC 394
            ..   .||...|.:      ..||.|..|..       .||:.|.:..:|..    :|.:.|.:|
Human   301 NT---SRNNSIHAMQMQLYTAETNKKDCQTG-------ATSANAPNSGSHKSHCTGEKTHKCPEC 355

  Fly   395 GRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISH-TGKKAFTCEICGVGLSQKS 458
            ||.:.....|.||...||||:||.|..|.||:..|..|.:|...| ..||.:.||.||..:.:.|
Human   356 GRAFFYQSFLMRHMKIHTGEKPYECGKCGKAFRYSLHLNKHLRKHVVQKKPYECEECGKVIRESS 420

  Fly   459 GYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCE 504
            .| .|:..|:|.|.:||..||..|..:|.|..|::.|..|||  ||
Human   421 KY-THIRSHTGEKPYKCKTCGKDFAKSSGLKKHLKTHKDEKP--CE 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dwgNP_477338.3 zf-AD 14..91 CDD:214871 16/77 (21%)
COG5048 <297..451 CDD:227381 49/164 (30%)
C2H2 Zn finger 307..327 CDD:275368 6/19 (32%)
C2H2 Zn finger 335..355 CDD:275368 4/25 (16%)
C2H2 Zn finger 363..383 CDD:275368 3/19 (16%)
COG5048 <387..523 CDD:227381 48/119 (40%)
C2H2 Zn finger 391..411 CDD:275368 7/19 (37%)
zf-H2C2_2 403..426 CDD:290200 12/22 (55%)
C2H2 Zn finger 419..439 CDD:275368 7/19 (37%)
C2H2 Zn finger 447..467 CDD:275368 7/19 (37%)
C2H2 Zn finger 475..495 CDD:275368 7/19 (37%)
zf-H2C2_2 487..510 CDD:290200 8/18 (44%)
C2H2 Zn finger 503..523 CDD:275368 2/2 (100%)
ZNF114NP_001318027.1 KRAB 52..111 CDD:214630 8/94 (9%)
KRAB 52..91 CDD:279668 7/74 (9%)
zf-C2H2 350..372 CDD:278523 7/21 (33%)
C2H2 Zn finger 352..372 CDD:275368 7/19 (37%)
zf-H2C2_2 365..389 CDD:290200 13/23 (57%)
C2H2 Zn finger 380..428 CDD:275368 17/48 (35%)
Ribosomal_L37ae 388..>445 CDD:302811 21/57 (37%)
zf-H2C2_2 423..444 CDD:290200 8/20 (40%)
zf-C2H2 434..456 CDD:278523 8/21 (38%)
C2H2 Zn finger 436..456 CDD:275368 7/19 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24384
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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