DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF846

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001071092.1	Gene:	ZNF846 / 162993	HGNCID:	27260	Length:	533	Species:	Homo sapiens

Alignment Length:	517	Identity:	146/517 - (28%)
Similarity:	231/517 - (44%)	Gaps:	95/517 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LLEQA----------FNFKRMVI-DSDEL----LRLGLDEARCSSFHESQTHSPNQSQQHDQQQQ 121
            ||:||          .|:|.::| ...||    |..||::     ..|.:|......|:.|.|.:
Human    24 LLDQAQRDLYRDVMLENYKNLIILAGSELFKRSLMSGLEQ-----MEELRTGVTGVLQELDLQLK 83

  Fly   122 AFDSTEEYVMIEMLNEE------QENVANLDEELAEEDR--RIFAMTVDEEEEFLTEEVDQDDEL 178
                |:...:::.::.|      |...:|..|:|.:.:.  ::|    :|....:|..:....|.
Human    84 ----TKGSPLLQDISAERSPNGVQLERSNTAEKLYDSNHSGKVF----NEHPFLMTHMITHIGEK 140

  Fly   179 SEEEHQLAQSGDQQEEHITMESVHE--FQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAIL 241
            :.|::|..::..:...|...:..|.  ..|..|::....|:|..:..:       |.:...:.:.
Human   141 TSEDNQSGKALRKNFPHSFYKKSHAEGKMPKCVKHEKAFNQFPNLTRQ-------NKTHTQEKLC 198

  Fly   242 DCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEAED---VCED--EDFLEES--LDSAPPTA 299
            :|       :......:.:.:|:|       |:.....|   ||::  :.|...|  :......:
Human   199 EC-------KDCWRTFLNQSSLKL-------HIRSHNGDKHYVCKECGKAFSNSSHLIGHGRIHS 249

  Fly   300 GEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCS 364
            ||. ||||..|.|||.|...|..|:|:|..||.|:|:||||...|.....:|...|:..||:.|.
Human   250 GEK-PYVCKECGKAFTQSTGLKLHIRTHSGEKPYKCKECGKAFTHSSYLTDHTRIHSGKKPYVCM 313

  Fly   365 ICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRH-------KL------------- 409
            .||:.:..::.|.:|.|.|..:|||.|.:||:.:....:|.:|       ||
Human   314 ECGKAFTRSTGLILHMRIHTGEKPYECKECGKAFIHSSYLTKHVRIHSGEKLYLCKACGKAFTRS 378

  Fly   410 --------THTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMV 466
                    |||||:||.|..|.||:.:||.|.||...|||:|.:.|:.||...:|.||...|:..
Human   379 SGLVLHMRTHTGEKPYECKECGKAFNNSSMLSQHVRIHTGEKPYECKECGKAFTQSSGLSTHLRT 443

  Fly   467 HSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            |:|.||.:|..||.||..::|||.|:|.|:||||:.|:.|.|||.....|..|.|.|....|
Human   444 HTGEKACECKECGKAFARSTNLNMHMRTHTGEKPYACKECGKAFRYSTYLNVHTRTHTGAKP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	9/33 (27%)
		COG5048	<297..451	CDD:227381	66/181 (36%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	64/163 (39%)
		C2H2 Zn finger	391..411	CDD:275368	7/47 (15%)
		zf-H2C2_2	403..426	CDD:290200	14/50 (28%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		zf-H2C2_2	487..510	CDD:290200	13/22 (59%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF846	NP_001071092.1	KRAB	8..67	CDD:214630	12/47 (26%)
		KRAB	8..45	CDD:279668	6/20 (30%)
		COG5048	106..496	CDD:227381	122/415 (29%)
		C2H2 Zn finger	120..136	CDD:275368	3/19 (16%)
		C2H2 Zn finger	200..220	CDD:275368	4/33 (12%)
		C2H2 Zn finger	228..248	CDD:275368	3/19 (16%)
		C2H2 Zn finger	256..276	CDD:275368	9/19 (47%)
		zf-H2C2_2	269..293	CDD:290200	12/23 (52%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-H2C2_2	296..321	CDD:290200	7/24 (29%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..347	CDD:290200	9/18 (50%)
		zf-C2H2	338..360	CDD:278523	6/21 (29%)
		C2H2 Zn finger	340..360	CDD:275368	5/19 (26%)
		zf-H2C2_2	352..377	CDD:290200	4/24 (17%)
		C2H2 Zn finger	368..388	CDD:275368	0/19 (0%)
		zf-H2C2_2	381..405	CDD:290200	11/23 (48%)
		C2H2 Zn finger	396..416	CDD:275368	9/19 (47%)
		zf-H2C2_2	408..433	CDD:290200	10/24 (42%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		zf-H2C2_2	437..461	CDD:290200	10/23 (43%)
		C2H2 Zn finger	452..472	CDD:275368	10/19 (53%)
		zf-H2C2_2	464..489	CDD:290200	15/24 (63%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		zf-H2C2_2	492..517	CDD:290200	5/14 (36%)
		C2H2 Zn finger	508..527	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910