DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF519

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_660330.2	Gene:	ZNF519 / 162655	HGNCID:	30574	Length:	540	Species:	Homo sapiens

Alignment Length:	510	Identity:	135/510 - (26%)
Similarity:	215/510 - (42%)	Gaps:	76/510 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LGSEGSTTLASMLNYCTGLSFEPQDGAAMPQHICLH-CLQLLEQAFNFKRMVIDSDELLRLGLDE 96
            ||..||..|.   |.|...::| ..|....|..|.: |.|.|..:.| |.:.:..|:..|:...:
Human    68 LGRYGSCGLE---NICLWKNWE-SIGEGEGQKECYNLCSQYLTTSHN-KHLTVKGDKEYRIFQKK 127

  Fly    97 ARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQ-------ENVANLDE---ELAE 151
            .:..|...::...|....||...:..|.:..:.......|..:       ||..|.:|   ...:
Human   128 PQFLSAAPTEPCIPMNKYQHKFLKSVFCNKNQINFNHDSNISKHHSTHFLENYYNCNECEKVFYQ 192

  Fly   152 EDRRIFAMTVD-EEEEFLTEEV-DQDDELSE-EEHQLAQSGDQQEEHITMESVHEFQPAEVEYVT 213
            ..:.||...:. :::.:.:.|. :..|..|: .:||....| :..:....:.:..|..:.::...
Human   193 SSKLIFPENIHIQKKPYNSNECGETSDPFSKLTQHQRIYIG-ESSQRCNKKCIIVFSQSHLKGHK 256

  Fly   214 IKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEA 278
            |.|..|..|..::..:... .|.|                    :|.:.:.
Human   257 IINTGEKSVKYKERGKAFT-RGLH--------------------LGHQKIH-------------- 286

  Fly   279 EDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLK 343
                                .||. ||.|..|.|||.:...|.||.|.|..||.::|:||||...
Human   287 --------------------TGEK-PYKCKKCDKAFNKSSHLAQHQRIHTGEKPFKCKECGKAFN 330

  Fly   344 HLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHK 408
            ......:|...||..:..:|..||:.:...|.|..|:|.|..:||:.|.:||:.:....::.:|:
Human   331 RGSYLTQHQRIHTGERAFKCEECGKAFNRGSYLTQHQRIHTGEKPFRCKECGKAFNRSSYVTQHQ 395

  Fly   409 LTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAH 473
            ..||||:|:.|..|.||:..:|.|.||:..|||:|.|.|:.||...::.|...:|..:|:|.|:.
Human   396 RMHTGEKPFKCKECGKAFNRASHLTQHQRIHTGEKHFKCKECGKAFNRGSHLTRHQRIHTGEKSF 460

  Fly   474 KCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESP 528
            ||:.||.||.:.|:|..|.|:|:|||.|||:.|.|||.....|..|.|:|..|.|
Human   461 KCEECGKAFIWGSHLTQHQRVHTGEKFFKCKECGKAFTRSSHLTQHQRIHTGEKP 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	17/58 (29%)
		COG5048	<297..451	CDD:227381	57/153 (37%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	56/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	5/19 (26%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF519	NP_660330.2	KRAB	4..43	CDD:279668
		KRAB	4..>43	CDD:214630
		C2H2 Zn finger	183..229	CDD:275368	7/45 (16%)
		zf-H2C2_2	282..302	CDD:290200	8/54 (15%)
		COG5048	290..>539	CDD:227381	89/227 (39%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:290200	12/24 (50%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		zf-H2C2_2	334..359	CDD:290200	6/24 (25%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..387	CDD:290200	9/24 (38%)
		C2H2 Zn finger	378..398	CDD:275368	4/19 (21%)
		zf-H2C2_2	393..415	CDD:290200	10/21 (48%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		zf-H2C2_2	418..443	CDD:290200	11/24 (46%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		zf-H2C2_2	446..469	CDD:290200	8/22 (36%)
		C2H2 Zn finger	462..482	CDD:275368	9/19 (47%)
		zf-H2C2_2	474..499	CDD:290200	14/24 (58%)
		C2H2 Zn finger	490..510	CDD:275368	8/19 (42%)
		zf-H2C2_2	502..527	CDD:290200	6/14 (43%)
		C2H2 Zn finger	518..538	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24384
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100