DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF583

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_005258615.1	Gene:	ZNF583 / 147949	HGNCID:	26427	Length:	570	Species:	Homo sapiens

Alignment Length:	489	Identity:	130/489 - (26%)
Similarity:	221/489 - (45%)	Gaps:	93/489 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 QSQQHDQQQQAFDSTEEYVMI-----------EMLNEEQENVANLDEELAEEDRRIFAMTVDEEE 165
            ::.:...:|:.::.:.:.|.:           ..|.|:.::......:|..::..:..:.:..:|
Human    85 KNSEFSSKQETYEESSKVVTVGARHLSYSLDYPSLREDCQSEDWYKNQLGSQEVHLSQLIITHKE 149

  Fly   166 EFLTEEVDQDDELSEEEHQLAQSG--DQQEEHITMESVHEFQPAEVEY--VTIKNEFETIVTEE- 225
              :..|| |:.|.::......|..  |.|:...|.|..|:.:|.:..|  .:::.:...:..|:
Human   150 --ILPEV-QNKEYNKSWQTFHQDTIFDIQQSFPTKEKAHKHEPQKKSYRKKSVEMKHRKVYVEKK 211

  Fly   226 -----DEFEVMNDSGA---HD---------AILDC-----QMIVIPAEGAIDEVIGEETLEL--- 265
                 |..:|.|.|.:   |.         |.::|     |...:.....|.  .||:..|.
Human   212 LLKCNDCEKVFNQSSSLTLHQRIHTGEKPYACVECGKTFSQSANLAQHKRIH--TGEKPYECKEC 274

  Fly   266 -EGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVD 329
             :...:..||.....                 ...||. ||.|..|:|||.|...|.||.|.|..
Human   275 RKAFSQNAHLAQHQR-----------------VHTGEK-PYQCKECKKAFSQIAHLTQHQRVHTG 321

  Fly   330 EKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQC 394
            |:.:||.||||...:.....:|...||..||:.|::||:.:.....|.||:|.|..::||.|.:|
Human   322 ERPFECIECGKAFSNGSFLAQHQRIHTGEKPYVCNVCGKAFSHRGYLIVHQRIHTGERPYECKEC 386

  Fly   395 GRGYAAFDHLRRHKLTHTGERPYACDL----------------------------CDKAYYDSSS 431
            .:.::.:.||.:|:..||||:||.|.:                            |.||:.:|||
Human   387 RKAFSQYAHLAQHQRVHTGEKPYECKVCRKAFSQIAYLDQHQRVHTGEKPYECIECGKAFSNSSS 451

  Fly   432 LRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHS 496
            |.||:.||||:|.:.|:.|....||.:|..:|..:|:|.|.::|:|||.||:::.:|..|.|:|:
Human   452 LAQHQRSHTGEKPYMCKECRKTFSQNAGLAQHQRIHTGEKPYECNVCGKAFSYSGSLTLHQRIHT 516

  Fly   497 GEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVT 530
            ||:|::|:.|.|:|..:..||.|.|:|..||.:|
Human   517 GERPYECKDCRKSFRQRAHLAHHERIHTMESFLT 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	64/181 (35%)
		C2H2 Zn finger	307..327	CDD:275368	10/19 (53%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	58/163 (36%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	12/50 (24%)
		C2H2 Zn finger	419..439	CDD:275368	10/47 (21%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	10/22 (45%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF583	XP_005258615.1	C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..392	CDD:290200	9/24 (38%)
		C2H2 Zn finger	383..403	CDD:275368	5/19 (26%)
		zf-H2C2_2	395..420	CDD:290200	10/24 (42%)
		C2H2 Zn finger	411..431	CDD:275368	1/19 (5%)
		zf-H2C2_2	423..448	CDD:290200	3/24 (13%)
		C2H2 Zn finger	439..459	CDD:275368	9/19 (47%)
		zf-H2C2_2	451..476	CDD:290200	11/24 (46%)
		C2H2 Zn finger	467..487	CDD:275368	6/19 (32%)
		zf-H2C2_2	480..504	CDD:290200	10/23 (43%)
		C2H2 Zn finger	495..515	CDD:275368	9/19 (47%)
		zf-H2C2_2	507..532	CDD:290200	11/24 (46%)
		C2H2 Zn finger	523..543	CDD:275368	8/19 (42%)
		KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		COG5048	210..543	CDD:227381	107/352 (30%)
		C2H2 Zn finger	215..235	CDD:275368	5/19 (26%)
		zf-H2C2_2	227..252	CDD:290200	3/24 (13%)
		C2H2 Zn finger	243..263	CDD:275368	2/19 (11%)
		zf-H2C2_2	255..280	CDD:290200	4/26 (15%)
		C2H2 Zn finger	271..291	CDD:275368	2/36 (6%)
		zf-H2C2_2	283..308	CDD:290200	11/42 (26%)
		C2H2 Zn finger	299..319	CDD:275368	10/19 (53%)
		zf-H2C2_2	311..336	CDD:290200	12/24 (50%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-H2C2_2	340..364	CDD:290200	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910