DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF582

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001307300.2	Gene:	ZNF582 / 147948	HGNCID:	26421	Length:	517	Species:	Homo sapiens

Alignment Length:	408	Identity:	127/408 - (31%)
Similarity:	198/408 - (48%)	Gaps:	30/408 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 EMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEV------------DQDDELSEEEHQL 185
            :::.|...|:.:|...:::.|  :.:.....:|.::.|.|            ....||..::|..
Human    33 DVMLETYSNLVSLGLAVSKPD--VISFLEQGKEPWMVERVVSGGLCPVLESRYDTKELFPKQHVY 95

  Fly   186 AQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPA 250
            .....|.|   .|||:..:   .:|..:.::::|.    .::|:  ...|..|.... |||:...
Human    96 EVESPQWE---IMESLTSY---GLECSSFQDDWEC----RNQFD--RQQGNPDRHFH-QMIIRHE 147

  Fly   251 EGAIDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFR 315
            |....:.....|...:...||:   |...:.|..:.:.:|.|.:.........||.|..|.|||:
Human   148 EMPTFDQHASLTFYQKIHTREK---PFGYNKCRKDFWQKELLINHQGIYTNEKPYKCKECGKAFK 209

  Fly   316 QQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHK 380
            ...||.||...|..:|.|||:||||......|:.:|...||..||::|..|.:.:..:|.|..|:
Human   210 YGSRLIQHENIHSGKKPYECKECGKAFNSGSNFIQHQRVHTGEKPYECKDCEKAFSRSSQLIEHQ 274

  Fly   381 RTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAF 445
            |||..:|||.|.:||:.:....||:.|...||||:||||..|.|.:...|.|.||:..|||:|.:
Human   275 RTHTGEKPYQCKECGKAFNRISHLKVHYRIHTGEKPYACKECGKTFSHRSQLIQHQTVHTGRKLY 339

  Fly   446 TCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAF 510
            .|:.||...:|.|...:|..:|:|.|.::|.|||.||..:|.|..|.|:|:||||::|:||.:||
Human   340 ECKECGKAFNQGSTLIRHQRIHTGEKPYECKVCGKAFRVSSQLKQHQRIHTGEKPYQCKVCGRAF 404

  Fly   511 PTKKRLASHMRVHNKESP 528
            .....|..|.|:|..|.|
Human   405 KRVSHLTVHYRIHTGEKP 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	62/153 (41%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	59/135 (44%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
ZNF582	NP_001307300.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910