DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and AgaP_AGAP011759

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_320751.4	Gene:	AgaP_AGAP011759 / 1280881	VectorBaseID:	AGAP011759	Length:	830	Species:	Anopheles gambiae

Alignment Length:	550	Identity:	145/550 - (26%)
Similarity:	231/550 - (42%)	Gaps:	93/550 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 MPQHICLHCLQLLEQAFNFKRMVIDSDELLRLGL---DEARCSSFHESQTHSPNQSQQHDQQQQA 122
            :|..:|..|...|::...|:...|.:||.||..|   |.....|...:....|:.: .|......
Mosquito    67 LPMFVCKLCANKLDEYVRFRDRCIANDEFLRNALAAFDANGGGSCPGAIKMEPDDT-AHPAVPPQ 130

  Fly   123 FDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQ 187
            ..::.::.....:...:.|.|.::...|...:|   ...|.|||        |:|........|.
Mosquito   131 PPASAKFAQCLAVTPLELNCALVEAAAAAAGKR---EPPDIEEE--------DEERGYGHGSGAP 184

  Fly   188 SGDQ----QEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVI 248
            |.|:    :.:.:|::..|..:|   .|.:         .:||: |::.|.|     .|.:....
Mosquito   185 SPDRSACGRVDELTVKRPHSDEP---HYHS---------GDEDD-ELLADDG-----YDGEPNQT 231

  Fly   249 PAEGA-----IDEVIGEETLELEGDGREEHLL-----------PEAEDVCEDEDFLEESLDSAPP 297
            |||.|     :.||. .::.::     ..|||           |.|:.:.|..||     :.|.|
Mosquito   232 PAEHADQQQYVCEVC-SKSFKI-----RHHLLVHRHTHVDSHAPTADMLHERADF-----NGATP 285

  Fly   298 TAGEA---LPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVK 359
            .||.|   ..|.|..|.|||..:..|..|:.:|..||.|.|:.|.|..|:....:.||..||..:
Mosquito   286 GAGGAGGKPSYSCPKCPKAFVNKGNLLNHLETHTHEKSYACDICTKTFKYNVQLRLHMRIHTGER 350

  Fly   360 PHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDK 424
            ||:|.||.|.:...|:|..|::||::.|||.|..|.:.:...|:|..|......:: :.|.||.|
Mosquito   351 PHKCEICNRGFSQLSNLRSHRKTHSKVKPYKCHLCLKSFTMLDNLTAHSAKCLKDK-FRCTLCSK 414

  Fly   425 AYYDSSSLRQHKISHTG---KKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTS 486
            ::....:|..|..||:.   :|.|.||:|......|..:|:|:.||:|.|.:.||:|...|...:
Mosquito   415 SFAKEGNLLSHLQSHSDGIVEKMFKCEMCPKSFKNKEDWKRHVRVHTGEKPYTCDICSKGFAQKA 479

  Fly   487 NLNAHVRLHSGEKP---FKCEVCVKAFPTKKRLASHM--------RVHNKESPVTA--TVAVQSI 538
            ||.:|.:.|.  ||   :.|:.|.:.|.::|.|..|:        .:.....|.:|  |...:||
Mosquito   480 NLLSHRKTHL--KPNVTYSCDRCARTFRSQKVLQMHVPKCTGGAGPIEGASVPPSAPVTPVSESI 542

  Fly   539 -NPPSRQAG------AEGATGGGATGGSPT 561
             :.||..||      :..|....|....||
Mosquito   543 PDSPSPGAGVSLTTTSSSAVEAAANSTPPT 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	8/29 (28%)
		COG5048	<297..451	CDD:227381	55/159 (35%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		COG5048	<387..523	CDD:227381	44/149 (30%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	6/22 (27%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	8/25 (32%)
		C2H2 Zn finger	503..523	CDD:275368	6/27 (22%)
AgaP_AGAP011759	XP_320751.4	zf-AD	24..98	CDD:214871	9/30 (30%)
		C2H2 Zn finger	243..263	CDD:275368	5/25 (20%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		C2H2 Zn finger	326..346	CDD:275368	6/19 (32%)
		zf-H2C2_2	339..363	CDD:290200	10/23 (43%)
		COG5048	<351..513	CDD:227381	54/164 (33%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		zf-H2C2_2	366..390	CDD:290200	9/23 (39%)
		C2H2 Zn finger	382..398	CDD:275368	4/15 (27%)
		C2H2 Zn finger	409..429	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	6/19 (32%)
		zf-H2C2_2	452..477	CDD:290200	10/24 (42%)
		C2H2 Zn finger	468..488	CDD:275368	7/19 (37%)
		C2H2 Zn finger	497..514	CDD:275368	5/16 (31%)
		C2H2 Zn finger	623..643	CDD:275368
		C2H2 Zn finger	722..742	CDD:275368
		C2H2 Zn finger	750..770	CDD:275368
		C2H2 Zn finger	780..800	CDD:275368
		zf-H2C2_2	792..817	CDD:290200
		C2H2 Zn finger	808..828	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910