DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and AgaP_AGAP011403

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_317913.2	Gene:	AgaP_AGAP011403 / 1278284	VectorBaseID:	AGAP011403	Length:	435	Species:	Anopheles gambiae

Alignment Length:	545	Identity:	115/545 - (21%)
Similarity:	191/545 - (35%)	Gaps:	193/545 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CRTCTRAC---KLHKPLQEEIDLGSEGSTTLASM--LNYCTGLSFEPQDGAAMPQHICLHCLQLL 73
            ||.|  .|   :|.:||..::|       ||..:  :...||:....:...:..  ||..|.|.|
Mosquito     8 CRLC--LCQDEQLLRPLTSKLD-------TLLKIEDVERFTGIKINVKGNISYA--ICFACTQKL 61

  Fly    74 EQAFNFKRMVIDSDELLRL--GLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLN 136
            ..:..|::..:::|.|..:  |:                           ...|||....:|.:.
Mosquito    62 TVSAKFRQCCLNNDALFEVLSGV---------------------------LIASTEGLQSVEAVG 99

  Fly   137 EEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESV 201
            |:.::                       ::..|::.|.||:.
Mosquito   100 EKSDS-----------------------QQAATDDDDDDDDY----------------------- 118

  Fly   202 HEFQPAEVEYVTIKNEFETIVTEEDE--FEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLE 264
                           |:|.:..||||  |:                                  .
Mosquito   119 ---------------EYEQVYEEEDESVFK----------------------------------R 134

  Fly   265 LEGDGREEHLLPEAEDVCE-DEDFLE---------------ESLDSAPPTAGEALPYVCTVCQKA 313
            .:|.|::|:.....|:..: |..::|               :|.:...|.||..| |..:|.|:|
Mosquito   135 ADGTGQQEYSYTHQEEESDSDTSYVEPADYSANYIDPGTQSDSDECGNPGAGPIL-YKWSVVQRA 198

  Fly   314 FRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAV 378
            ....      ...|.|......|.|..|.:  ::||:..|         |:|||:.   .:||:|
Mosquito   199 AAAS------TVEHDDSSSQASEICTMRTR--KSYKQQQL---------CTICGKL---VTSLSV 243

  Fly   379 HKRT-HAEKKPYNCDQC-----GRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKI 437
            |..: |.:.:.:.|..|     .:|... .|:|...|....||   |.||.|.|.:.:||:.|.:
Mosquito   244 HTNSVHKQARVHACPHCPIAMTNKGNLV-KHVRAVHLKLLCER---CKLCGKGYTNRNSLKSHML 304

  Fly   438 SH--TGKKAFTCEICGVGLSQKSGYKKHM-MVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEK 499
            :.  .|::| .|::|....:|||....|| .:||.|:..:||:||..|.....|..|..:||.|:
Mosquito   305 AQHGIGERA-KCKLCPKQFNQKSALHDHMKRIHSNVRPLECDICGKQFKVRRALRVHKSVHSDEQ 368

  Fly   500 PFKCEVCVKAFPTKKRLASHMRVHN 524
            |:.|..|.|.|.::.....|.|.|:
Mosquito   369 PYACGKCPKRFKSRHACNIHERTHS 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	20/81 (25%)
		COG5048	<297..451	CDD:227381	44/161 (27%)
		C2H2 Zn finger	307..327	CDD:275368	3/19 (16%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	8/20 (40%)
		COG5048	<387..523	CDD:227381	45/143 (31%)
		C2H2 Zn finger	391..411	CDD:275368	6/24 (25%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	7/20 (35%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	9/22 (41%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
AgaP_AGAP011403	XP_317913.2	zf-AD	7..79	CDD:214871	20/81 (25%)
		C2H2 Zn finger	231..249	CDD:275368	8/20 (40%)
		C2H2 Zn finger	257..278	CDD:275368	5/21 (24%)
		C2H2 Zn finger	286..307	CDD:275368	8/20 (40%)
		C2H2 Zn finger	315..336	CDD:275368	7/20 (35%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		C2H2 Zn finger	399..420	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910