DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and AgaP_AGAP005390

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_001688655.1	Gene:	AgaP_AGAP005390 / 1276091	VectorBaseID:	AGAP005390	Length:	676	Species:	Anopheles gambiae

Alignment Length:	700	Identity:	151/700 - (21%)
Similarity:	231/700 - (33%)	Gaps:	219/700 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 KLHKPLQEEIDL----GSEGSTTLASM----LNYCTGLSFEP---------QD-GAAMPQHIC-- 66
            ||:.|::....|    .|...||:...    .:|.|....||         || |....||:.
Mosquito    50 KLYSPIKYSSPLRHCDSSSKMTTMVDFSSVPTSYHTLRRTEPGQTIILEEIQDKGYVTKQHLFST 114

  Fly    67 -------LHCLQLLEQAFNFKRMVIDSD-------ELLRLGLDEARCSSFHESQTHSP-NQSQQH 116
                   ||.|...|.|.    |.:.:.       |::                 |.| :.:...
Mosquito   115 SEPLAMDLHTLSAAEDAL----MAVPAKKKWTKKWEII-----------------HGPVSPAGPI 158

  Fly   117 DQQQQAFDSTEEYV-MIEMLNEEQENVAN-----LDEELAEEDRR----IFAMTVDEEEEFL--- 168
            .||||.....||.| ::..:..||:.:|.     |...:|:.:|.    .:|.|.....|.:
Mosquito   159 IQQQQPQHQVEEPVYIVRPVQVEQQQIATHVSSPLILSVADNERSSGLIYYAPTTIRRVEDIPLG 223

  Fly   169 TEEVDQDDELSEEEHQLAQ-------------------SGDQQEEHITMESVHEFQPAEVEY--- 211
            |.:|..|.|..:|..:..|                   ...||.......|..|.|.|...|
Mosquito   224 TVDVGDDKECPKERDKEMQLYTIIECPELGPESAVSCFGNGQQVAFCGSSSSEESQDAVQGYSHK 288

  Fly   212 VTIKNEFETIVT-------EEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDG 269
            |..:.:...|.|       ...|....::|.:.||:|   |.|            ||..|....|
Mosquito   289 VFDRKKSRKIRTVSCRSSSGSSEGGTHSESTSQDAVL---MHV------------EELAESVRPG 338

  Fly   270 REEHLLPE-AEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQY 333
            ..|   || ::|...|.:  ....|.....:||.     |...:                .|..:
Mosquito   339 SSE---PEGSQDTSNDSE--HSGADDQAMKSGEE-----TTTSR----------------PEDVH 377

  Fly   334 ECEECGKRLKHLRNYKEHMLTHTNV---KPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCG 395
            .|.||.||.....|...|..||.::   |..:|..|.:.|.:..:.::|.|||.:..  .|..|.
Mosquito   378 VCPECNKRYSTSSNLARHRQTHRSLEDQKARRCPYCSKVYVSMPAYSMHVRTHDQGS--KCPTCD 440

  Fly   396 RGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGY 460
            :.::....|:.|..|||||:|:.|.:|.||:.|.|:||.|..:|:..|.:.|..||...:.||..
Mosquito   441 KRFSRPWLLQGHIRTHTGEKPFKCSVCSKAFADKSNLRAHVQTHSNTKPYQCGRCGKSFALKSYL 505

  Fly   461 KKH-------------------------------------------------MMVHSGVKAHKC- 475
            .||                                                 :...||....:|
Mosquito   506 CKHEDSSCLKNDKPVKVRKPTTGSGRSSVRRAKPTRSSERSAPAGSEERSNGVAESSGTNGLQCG 570

  Fly   476 -DVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVK----AFPTKKRLASHMRVHNKESPVTATVAV 535
             ....:.:.:.:|:           |||..:..|    .....||.|..:...|..:|:..:|:
Mosquito   571 QQASDNRYNYPANV-----------PFKDVLRAKIREVVEDNCKRTARMLAAANGTTPLNGSVS- 623

  Fly   536 QSINPPSRQAGA---EGATGGGATGGS-PTGGGATGGSATNLHITEVHEQ 581
            :...|.|.:...   .|:.||.|..|| ||...::..|:.:   ||.|.:
Mosquito   624 REPTPQSNRISVIRIAGSPGGYALDGSRPTSSNSSSSSSNS---TEYHAE 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	23/102 (23%)
		COG5048	<297..451	CDD:227381	43/156 (28%)
		C2H2 Zn finger	307..327	CDD:275368	1/19 (5%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		COG5048	<387..523	CDD:227381	39/190 (21%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	7/68 (10%)
		C2H2 Zn finger	475..495	CDD:275368	2/21 (10%)
		zf-H2C2_2	487..510	CDD:290200	5/26 (19%)
		C2H2 Zn finger	503..523	CDD:275368	4/23 (17%)
AgaP_AGAP005390	XP_001688655.1	zf-C2H2	377..399	CDD:278523	7/21 (33%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		COG5048	430..>517	CDD:227381	29/88 (33%)
		zf-C2H2	435..456	CDD:278523	4/20 (20%)
		C2H2 Zn finger	436..456	CDD:275368	4/19 (21%)
		zf-H2C2_2	449..472	CDD:290200	12/22 (55%)
		zf-C2H2	462..484	CDD:278523	9/21 (43%)
		C2H2 Zn finger	464..484	CDD:275368	9/19 (47%)
		zf-H2C2_2	476..500	CDD:290200	8/23 (35%)
		C2H2 Zn finger	492..508	CDD:275368	5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910