DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and AgaP_AGAP010926

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_309767.4	Gene:	AgaP_AGAP010926 / 1271025	VectorBaseID:	AGAP010926	Length:	443	Species:	Anopheles gambiae

Alignment Length:	368	Identity:	86/368 - (23%)
Similarity:	136/368 - (36%)	Gaps:	115/368 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 LEGDGREEHLLPEAEDVCEDEDFLEESL---DSAPPTAGEALPY------VCTVCQKAFRQQCRL 320
            |....|:..|.||.|::.:::..|..|:   .|.|.....||.:      ..::|:|.     .:
Mosquito    87 LNASSRDYTLTPEKEEIVDEDMPLNLSMKPSTSTPNARHAALTHSINIWSPASMCEKE-----TI 146

  Fly   321 NQHMRSHVD-------EKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCS-------ICGRFYR 371
            :...:|::|       ....:.:|......|..::..|   |   :|||..       ...|...
Mosquito   147 DGDNQSNIDIENDDDSSGDLQIDESFDSQHHHHHHHHH---H---QPHQHQERQDRQRETARILT 205

  Fly   372 TTSSLAVHKR------THAEKKPYNCDQCGRGYAAFDHLRRHK---------------------- 408
            ..:||.::.|      :.:.:..:|..:..:||  |.||::.:
Mosquito   206 EYNSLLLNGRQSGGGGSRSSQDYFNYSKISKGY--FTHLQQQQKNLEILRQNRTDLFVLNGGNDN 268

  Fly   409 --------------------------------LTHTGERP------------------YACDLCD 423
                                            ::|..||.                  :.|..|.
Mosquito   269 NNKEGVKNQNQTGHERSGGAGSKQNWDRKLFGISHPVERKIPFDDHASPPKKKMPGRLHQCKQCG 333

  Fly   424 KAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNL 488
            |.:..||:|..|.:.|:..:.:.|:.||....|||..|||..:|:|.|.|||.||..||:.:|||
Mosquito   334 KTFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTYIHTGEKPHKCVVCLKAFSQSSNL 398

  Fly   489 NAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTA 531
            ..|:|.|||.|||.|.:|.|||..|..|..|....:.| |.||
Mosquito   399 ITHMRKHSGYKPFSCGLCDKAFQRKVDLRRHREGQHNE-PATA 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	35/251 (14%)
		C2H2 Zn finger	307..327	CDD:275368	2/19 (11%)
		C2H2 Zn finger	335..355	CDD:275368	3/19 (16%)
		C2H2 Zn finger	363..383	CDD:275368	4/32 (13%)
		COG5048	<387..523	CDD:227381	55/207 (27%)
		C2H2 Zn finger	391..411	CDD:275368	5/73 (7%)
		zf-H2C2_2	403..426	CDD:290200	8/94 (9%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	10/19 (53%)
		zf-H2C2_2	487..510	CDD:290200	13/22 (59%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
AgaP_AGAP010926	XP_309767.4	zf-C2H2	327..349	CDD:278523	7/21 (33%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		COG5048	337..>413	CDD:227381	35/75 (47%)
		zf-H2C2_2	342..366	CDD:290200	6/23 (26%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	13/24 (54%)
		C2H2 Zn finger	385..405	CDD:275368	10/19 (53%)
		zf-H2C2_2	397..420	CDD:290200	13/22 (59%)
		C2H2 Zn finger	413..430	CDD:275368	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910