DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and Zfp37

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_478116.2	Gene:	Zfp37 / 115768	RGDID:	620723	Length:	626	Species:	Rattus norvegicus

Alignment Length:	467	Identity:	142/467 - (30%)
Similarity:	211/467 - (45%)	Gaps:	54/467 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 ARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLD------------EEL 149
            :.|:...:...||     :||..::....:..|.  :.||:      |||            .:.
  Rat   147 SECTLLEKKNVHS-----KHDPSEKRLHKSNLYG--KNLNQ------NLDLPSQIKISAKKKPDT 198

  Fly   150 AEEDRRIF---AMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESV--HEFQPAEV 209
            |.|.|:..   |..|:.:|....::.|:     ...::|...||:.:.....|.|  |.....:.
  Rat   199 ANEYRKSLSHSASDVNRDEISTRKKCDK-----SPNNKLFGKGDKNQTGKKCEKVCRHSASHTKE 258

  Fly   210 EYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEV---IGEETLELEGDG-- 269
            :.:....:.::......:.:....||.......|..::...:|.:|..   .||:..|....|
  Rat   259 DKIHTGEKRKSPCRSPSKSDKAPGSGKPYECNQCGKVLSHKQGLLDHQRTHTGEKPYECNECGIA 323

  Fly   270 --REEHLL----------PEAEDVCEDEDFLEESL-DSAPPTAGEALPYVCTVCQKAFRQQCRLN 321
              ::.||:          |.....|......:.:| |......||. ||.|..|.|.||....|.
  Rat   324 FSQKSHLVVHQRTHTGEKPYECVQCGKAHGHKHALTDHLRIHTGEK-PYKCNECGKTFRHSSNLM 387

  Fly   322 QHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEK 386
            ||:|||..||.|||:||||..::..:..||:.|||...|::|:.||:.::..|||..|.|.|..:
  Rat   388 QHIRSHTGEKPYECKECGKSFRYNSSLTEHVRTHTGEIPYECNECGKAFKYGSSLTKHMRIHTGE 452

  Fly   387 KPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICG 451
            ||:.|.:||:.::...||..|:.|||.|:||.|..|.||:..||||..|..:|||...|.|..||
  Rat   453 KPFECTECGKTFSKKSHLVIHQRTHTKEKPYKCKECGKAFGHSSSLTYHLRTHTGDCPFECNQCG 517

  Fly   452 VGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRL 516
            ....|..|..:|..||:|.|.::|..||.||:..|:|..|.|.|:|||||:|..|.|||..|.:|
  Rat   518 KAFKQIEGLTQHQRVHTGEKPYECVECGKAFSQKSHLIVHQRTHTGEKPFECYECGKAFNAKSQL 582

  Fly   517 ASHMRVHNKESP 528
            ..|.|.|..|.|
  Rat   583 VIHQRSHTGEKP 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	67/153 (44%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	61/135 (45%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
Zfp37	NP_478116.2	KRAB_A-box	28..68	CDD:143639
		KRAB	41..89	CDD:214630
		COG5048	124..518	CDD:227381	107/389 (28%)
		C2H2 Zn finger	243..262	CDD:275368	3/18 (17%)
		C2H2 Zn finger	289..309	CDD:275368	3/19 (16%)
		zf-H2C2_2	302..326	CDD:290200	5/23 (22%)
		C2H2 Zn finger	317..337	CDD:275368	3/19 (16%)
		zf-H2C2_2	329..351	CDD:290200	4/21 (19%)
		C2H2 Zn finger	345..365	CDD:275368	3/19 (16%)
		zf-H2C2_2	357..382	CDD:290200	10/25 (40%)
		zf-C2H2	371..393	CDD:278523	10/21 (48%)
		C2H2 Zn finger	373..393	CDD:275368	9/19 (47%)
		zf-H2C2_2	385..410	CDD:290200	15/24 (63%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		zf-H2C2_2	413..438	CDD:290200	9/24 (38%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		zf-H2C2_2	441..465	CDD:290200	10/23 (43%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		zf-H2C2_2	469..492	CDD:290200	12/22 (55%)
		C2H2 Zn finger	485..505	CDD:275368	9/19 (47%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	526..550	CDD:290200	10/23 (43%)
		C2H2 Zn finger	541..561	CDD:275368	9/19 (47%)
		zf-H2C2_2	553..577	CDD:290200	13/23 (57%)
		COG5048	565..>626	CDD:227381	15/30 (50%)
		C2H2 Zn finger	569..589	CDD:275368	9/19 (47%)
		zf-H2C2_2	582..606	CDD:290200	6/13 (46%)
		C2H2 Zn finger	597..617	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910