DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and AgaP_AGAP013275

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_003436998.1	Gene:	AgaP_AGAP013275 / 11175887	VectorBaseID:	AGAP013275	Length:	2302	Species:	Anopheles gambiae

Alignment Length:	696	Identity:	128/696 - (18%)
Similarity:	214/696 - (30%)	Gaps:	250/696 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PLQEEIDLGSEGSTTLASMLNYCTGLSFEPQDGAAMPQHICLHCLQLLEQAFNFKRMVIDSDELL 90
            |...::.||..|:.....          .|:........:|..|                   .:
Mosquito   570 PAGRQLGLGPHGTAPAGR----------RPKGTGTAKNKVCTGC-------------------SI 605

  Fly    91 RLGLDEARCSSFHESQTHSPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRR 155
            :.|.|:...|:...:.::....:|..:|.:......:.::......:|      ||:|:.::
Mosquito   606 KHGADQCPLSTPLRAISNKIELTQWLEQNEDLIKKHKLFLKPPGTGDE------LDDEMDDQ--- 661

  Fly   156 IFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFET 220
                 .||:|:      |.:|::.:||.   ..|:....:..:|....|..     |::..|||
Mosquito   662 -----YDEDED------DDEDDVEDEEE---DGGESSRGNGKVELTPSFSE-----VSVPPEFE- 706

  Fly   221 IVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEET-----LELE-----GDGREEHLL 275
                               :..|     |...|...:|...|     |:|:     ||.:....|
Mosquito   707 -------------------LRPC-----PQSSANGTIISSTTQSADALQLQKLGQLGDSQPPVSL 747

  Fly   276 PEAE--------DVCEDEDFLEESLDSAPP----------------TAGEALP--------YVCT 308
            |:.:        |:.:|:|.|.:|..|.||                ||.::.|        |..|
Mosquito   748 PQQQQQQQGQGHDLQQDQDSLLDSKSSLPPASTLAGFAGTLGADRETAPKSRPAGGHGLSIYTTT 812

  Fly   309 VCQKAFR---------------------------------------------------------Q 316
            ...|..:                                                         :
Mosquito   813 FIAKYTKLGPLTGQIVRETEIQDDCTMRHIFETFDGAKSTYTSTENKNFSNWLRYIRPARNREQK 877

  Fly   317 QCRLNQH------------------------MRSHVDEKQYE---CEECGKRLKHLRNYKEH-ML 353
            .|.|..|                        ..|...:|:.|   |..|..:..|...|:.| .:
Mosquito   878 NCVLQVHDGSIYFVTCRDLEPGAELLYWSNDSNSAWGKKKMEKTNCGGCNLKFDHPFYYRTHCSV 942

  Fly   354 TH-----TNVKPHQCSICGRFYRTTSSLAVH-KRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHT 412
            .|     ..::.:.|.:||.......::..| ::.|..|..|.|..|.:.:...::|..|:....
Mosquito   943 FHDPGFSLTIRKYHCKVCGAAVLGKENIMKHAEKLHDGKGAYQCQFCQKFFLRLNYLEMHRTYGC 1007

  Fly   413 GERPY----ACDLCDKAYYDSSSLRQH-KISHTGK----KAFTCEICGVGLSQKSGYKKHMM-VH 467
            ...|.    .||.|.:.:.....|:.| |..|:..    :.|.|::|...|..::..::|.. ||
Mosquito  1008 SANPQRTRPLCDFCGRKFCQPQKLKVHIKRMHSDMADVLRDFQCKLCSKLLGSRAALQRHSKEVH 1072

  Fly   468 SGVKA-HKCDVCGHAFTFTSNLNAHVRLHSGEKPFKC--EVCVKAFPTKKRLASH-MRVH---NK 525
            |...| ..|..|...|...|||..|:..|||.:||||  ..|..||.||:.|..| .:||   .:
Mosquito  1073 SRNSAVVSCPRCQKLFQNRSNLKIHMLTHSGVRPFKCAENECTAAFTTKQCLQFHYKKVHGYTQE 1137

  Fly   526 ESP-VTATVA-----------------VQSINPPSRQAGAEGATGG 553
            :.| :..:||                 ||........|..||..||
Mosquito  1138 QMPKIERSVAYTFDAYSGGLNDGIIDEVQRRQRHKSTASEEGGYGG 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	7/64 (11%)
		COG5048	<297..451	CDD:227381	40/277 (14%)
		C2H2 Zn finger	307..327	CDD:275368	5/100 (5%)
		C2H2 Zn finger	335..355	CDD:275368	5/20 (25%)
		C2H2 Zn finger	363..383	CDD:275368	4/20 (20%)
		COG5048	<387..523	CDD:227381	43/149 (29%)
		C2H2 Zn finger	391..411	CDD:275368	4/19 (21%)
		zf-H2C2_2	403..426	CDD:290200	6/26 (23%)
		C2H2 Zn finger	419..439	CDD:275368	6/20 (30%)
		C2H2 Zn finger	447..467	CDD:275368	4/20 (20%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	11/24 (46%)
		C2H2 Zn finger	503..523	CDD:275368	8/22 (36%)
AgaP_AGAP013275	XP_003436998.1	SET	803..905	CDD:214614	6/101 (6%)
		PHD_SF	919..>967	CDD:304600	10/47 (21%)
		C2H2 Zn finger	923..939	CDD:275368	4/15 (27%)
		C2H2 Zn finger	957..978	CDD:275368	4/20 (20%)
		C2H2 Zn finger	986..1014	CDD:275368	5/27 (19%)
		C2H2 Zn finger	1018..1039	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1051..1072	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1081..1101	CDD:275368	7/19 (37%)
		zf-H2C2_2	1093..1120	CDD:290200	13/26 (50%)
		C2H2 Zn finger	1109..1132	CDD:275368	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910