DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and ZNF660-ZNF197

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001338661.1	Gene:	ZNF660-ZNF197 / 110354863	-ID:	-	Length:	1029	Species:	Homo sapiens

Alignment Length:	640	Identity:	168/640 - (26%)
Similarity:	257/640 - (40%)	Gaps:	158/640 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SKIAEVVVL---------NCRTCTRACKLHKP--------LQEEIDLGSEG-----------STT 40
            ::|.|::||         ..||..   :||.|        |.||:....:|           ..|
Human    79 AQILELLVLEQFLSILPGEIRTWV---QLHHPGSGEEAVALVEELQKDLDGPAIQVPVLVKDQDT 140

  Fly    41 LASMLNYCTGLSFEP-QDGAAMPQHICLHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHE 104
            |..::: ..|.:..| ..|:.:...||.|....| .|||.:....||.      ..||...|..|
Human   141 LQKVVS-APGTTLPPVLPGSHIAAEICPHPPTDL-VAFNLQDPQHDSP------APEASALSQEE 197

  Fly   105 SQ----------THSPNQSQQHDQQQQAFDSTEEYVMI---------EMLNEEQENVANLDEELA 150
            :.          |..|.:....::....|.| ||:..:         :::.|...||.:|:.|
Human   198 NPRNQLMALMLLTAQPQELVMFEEVSVCFTS-EEWACLGPIQRALYWDVMLENYGNVTSLEWE-- 259

  Fly   151 EEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIK 215
                     |:.|.||..::.       |..:...:..|..:....::..|.:|: .|.|:..:.
Human   260 ---------TMTENEEVTSKP-------SSSQRADSHKGTSKRLQGSVPQVLDFE-EECEWQVLA 307

  Fly   216 NEF--------ETI----VTEED------------EFEVMNDSGAHDAILDCQMIVIPAEG---- 252
            :::        :|:    :.|.|            :::.:.||....:.:...:  |..||
Human   308 SQWGNETDERADTVKKVSLCERDKKKRTPPEKQGQKWKELGDSLTFGSAISESL--IGTEGKKFY 370

  Fly   253 ----------AIDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEES--LDSAPPTAGEALPY 305
                      .|..:|....:.   .|.:.|...|.     .:.|::.|  |......:||. ||
Human   371 KCDMCCKHFNKISHLINHRRIH---TGEKPHKCKEC-----GKGFIQRSSLLMHLRNHSGEK-PY 426

  Fly   306 VCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGK-------RLKHLRN------YK-------- 349
            .|..|.|||.|...|..|.|.|..||.|:|:||||       .:.|||.      ||
Human   427 KCNECGKAFSQSAYLLNHQRIHTGEKPYKCKECGKGFYRHSGLIIHLRRHSGERPYKCNECGKVF 491

  Fly   350 -------EHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRH 407
                   :|...|...:|::|:.|.:.:....||.:|:|.|:.:|||.||:||:.:|...:|..|
Human   492 SQNAYLIDHQRLHKGEEPYKCNKCQKAFILKKSLILHQRIHSGEKPYKCDECGKTFAQTTYLIDH 556

  Fly   408 KLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKA 472
            :..|:.|.||.|..|.|.:..|.||..|:..||.||.|.|:.||...|.||.:..|..:||..|.
Human   557 QRLHSAENPYKCKECGKVFIRSKSLLLHQRVHTEKKTFGCKKCGKIFSSKSNFIDHKRMHSREKP 621

  Fly   473 HKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKES 527
            :||..||.|||.::.|..|.|||:||||::|..|.|.|..||.|..|.|.|..|:
Human   622 YKCTECGKAFTQSAYLFDHQRLHNGEKPYECNECGKVFILKKSLILHQRFHTGEN 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	23/96 (24%)
		COG5048	<297..451	CDD:227381	64/181 (35%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	11/47 (23%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	61/135 (45%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
ZNF660-ZNF197	NP_001338661.1	SCAN	38..150	CDD:128708	15/74 (20%)
		KRAB	216..256	CDD:307490	7/40 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..290		5/34 (15%)
		C2H2 Zn finger	372..392	CDD:275368	2/19 (11%)
		zf-H2C2_2	384..409	CDD:316026	5/32 (16%)
		C2H2 Zn finger	400..420	CDD:275368	4/24 (17%)
		COG5048	424..853	CDD:227381	98/254 (39%)
		C2H2 Zn finger	428..448	CDD:275368	9/19 (47%)
		C2H2 Zn finger	456..476	CDD:275368	8/19 (42%)
		C2H2 Zn finger	484..504	CDD:275368	1/19 (5%)
		C2H2 Zn finger	512..532	CDD:275368	6/19 (32%)
		C2H2 Zn finger	540..560	CDD:275368	7/19 (37%)
		C2H2 Zn finger	568..588	CDD:275368	7/19 (37%)
		C2H2 Zn finger	596..616	CDD:275368	7/19 (37%)
		C2H2 Zn finger	624..644	CDD:275368	9/19 (47%)
		C2H2 Zn finger	652..672	CDD:275368	9/19 (47%)
		C2H2 Zn finger	680..700	CDD:275368
		C2H2 Zn finger	708..728	CDD:275368
		C2H2 Zn finger	736..756	CDD:275368
		COG5048	760..>1026	CDD:227381
		C2H2 Zn finger	764..784	CDD:275368
		C2H2 Zn finger	792..812	CDD:275368
		C2H2 Zn finger	820..840	CDD:275368
		C2H2 Zn finger	848..868	CDD:275368
		C2H2 Zn finger	876..896	CDD:275368
		C2H2 Zn finger	904..924	CDD:275368
		C2H2 Zn finger	932..952	CDD:275368
		C2H2 Zn finger	960..980	CDD:275368
		C2H2 Zn finger	988..1008	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910