DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and LOC103910897

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_021331401.1	Gene:	LOC103910897 / 103910897	-ID:	-	Length:	1691	Species:	Danio rerio

Alignment Length:	321	Identity:	119/321 - (37%)
Similarity:	162/321 - (50%)	Gaps:	45/321 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGR 368
            |..||:|.|:|||...|::|||:|..||.:.|.:|||......|:..||..||..||..|:.||:
Zfish   737 PITCTLCGKSFRQSSSLSKHMRTHTGEKPFTCTQCGKSFSQSSNFNLHMRIHTGEKPFTCTQCGK 801

  Fly   369 FYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLR 433
            .:|..|||..|.|||..:||:.|.|||:.:....||.:|...||||:|..|..|.|::..||||.
Zfish   802 SFRQASSLNKHTRTHTGEKPFTCTQCGKSFNRSSHLNQHIRIHTGEKPITCTQCGKSFRQSSSLY 866

  Fly   434 QHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVK-----------------AHK------- 474
            :|...|||:|.|||..||..|:.||..|.||.:|:|.|                 .||
Zfish   867 KHMRIHTGEKPFTCSQCGKSLASKSKLKTHMRIHTGEKPFTCYQYGKSFSKSSLYRHKKIHTGKK 931

  Fly   475 ---CDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQ 536
               |..||.:|..:|:||.|:|:|:|||||:|..|.|:|.....|..||.:|..|.|.|.|...:
Zfish   932 TFTCTQCGKSFNCSSHLNQHIRIHTGEKPFRCTQCGKSFNCSSHLNEHMMIHTGEKPFTCTQCGK 996

  Fly   537 SINPPS---RQAGAEGATGGGATGGSP-----TGGGATGGSATNLHITEVH--EQPVSTSK 587
            |.:..|   |.....       ||..|     .....:..|:.|||: .:|  |:|.:.::
Zfish   997 SFSKSSSLYRHMKIH-------TGEKPYTCTECRKSFSQSSSLNLHM-RIHTGEKPFTCTE 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	66/146 (45%)
		C2H2 Zn finger	307..327	CDD:275368	11/19 (58%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	9/19 (47%)
		COG5048	<387..523	CDD:227381	64/162 (40%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	13/22 (59%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
LOC103910897	XP_021331401.1	C2H2 Zn finger	68..88	CDD:275368
		zf-H2C2_2	81..105	CDD:316026
		C2H2 Zn finger	96..116	CDD:275368
		zf-H2C2_2	108..133	CDD:316026
		C2H2 Zn finger	124..144	CDD:275368
		zf-H2C2_2	137..161	CDD:316026
		C2H2 Zn finger	152..172	CDD:275368
		zf-H2C2_2	164..189	CDD:316026
		C2H2 Zn finger	180..200	CDD:275368
		zf-H2C2_2	192..217	CDD:316026
		C2H2 Zn finger	208..228	CDD:275368
		zf-H2C2_2	220..245	CDD:316026
		C2H2 Zn finger	236..256	CDD:275368
		COG5048	260..700	CDD:227381
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	320..340	CDD:275368
		C2H2 Zn finger	348..368	CDD:275368
		C2H2 Zn finger	376..396	CDD:275368
		C2H2 Zn finger	404..424	CDD:275368
		C2H2 Zn finger	432..452	CDD:275368
		C2H2 Zn finger	460..480	CDD:275368
		C2H2 Zn finger	488..508	CDD:275368
		COG5048	512..925	CDD:227381	78/187 (42%)
		C2H2 Zn finger	516..536	CDD:275368
		C2H2 Zn finger	544..564	CDD:275368
		C2H2 Zn finger	572..592	CDD:275368
		C2H2 Zn finger	600..620	CDD:275368
		C2H2 Zn finger	628..648	CDD:275368
		C2H2 Zn finger	656..676	CDD:275368
		C2H2 Zn finger	684..704	CDD:275368
		C2H2 Zn finger	712..732	CDD:275368
		C2H2 Zn finger	740..760	CDD:275368	11/19 (58%)
		C2H2 Zn finger	768..788	CDD:275368	7/19 (37%)
		C2H2 Zn finger	796..816	CDD:275368	9/19 (47%)
		C2H2 Zn finger	824..844	CDD:275368	7/19 (37%)
		C2H2 Zn finger	852..872	CDD:275368	8/19 (42%)
		C2H2 Zn finger	880..900	CDD:275368	9/19 (47%)
		COG5048	930..1340	CDD:227381	40/128 (31%)
		C2H2 Zn finger	935..955	CDD:275368	9/19 (47%)
		C2H2 Zn finger	963..983	CDD:275368	7/19 (37%)
		C2H2 Zn finger	991..1011	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1019..1039	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1047..1067	CDD:275368	0/3 (0%)
		C2H2 Zn finger	1075..1095	CDD:275368
		C2H2 Zn finger	1103..1123	CDD:275368
		C2H2 Zn finger	1131..1150	CDD:275368
		C2H2 Zn finger	1158..1178	CDD:275368
		C2H2 Zn finger	1186..1206	CDD:275368
		C2H2 Zn finger	1214..1234	CDD:275368
		C2H2 Zn finger	1242..1262	CDD:275368
		COG5048	1266..1670	CDD:227381
		C2H2 Zn finger	1270..1290	CDD:275368
		C2H2 Zn finger	1298..1318	CDD:275368
		C2H2 Zn finger	1326..1346	CDD:275368
		C2H2 Zn finger	1354..1374	CDD:275368
		C2H2 Zn finger	1382..1402	CDD:275368
		C2H2 Zn finger	1410..1430	CDD:275368
		C2H2 Zn finger	1438..1458	CDD:275368
		C2H2 Zn finger	1466..1486	CDD:275368
		C2H2 Zn finger	1522..1542	CDD:275368
		C2H2 Zn finger	1550..1570	CDD:275368
		C2H2 Zn finger	1578..1598	CDD:275368
		C2H2 Zn finger	1606..1626	CDD:275368
C2H2 Zn finger	1634..1654	CDD:275368
C2H2 Zn finger	1662..1682	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910