DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and LOC102549842

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_006227879.1	Gene:	LOC102549842 / 102549842	RGDID:	7600894	Length:	889	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	122/353 - (34%)
Similarity:	176/353 - (49%)	Gaps:	41/353 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 EHQLAQSGDQQEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDCQMI 246
            |||...|   ||....:|...|...|.:|.    ::.:|..|||..:.......|..|   |.::
  Rat   211 EHQKIHS---QENLFKIEVCSEIFCAPIEL----SKDQTFCTEEKPYRYEEYVKAFSA---CSLL 265

  Fly   247 -----VIPAEGAID-EVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPY 305
                 :.|.|.|.. |..|.....|       |.:.:....||.:.                  |
  Rat   266 SEHPRIHPGEKAFKCEECGNAFCTL-------HSVSKVNIHCEVKS------------------Y 305

  Fly   306 VCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFY 370
            .|..|.|||.....|.||...|..||.|:||||||......|.|:|.:||:..||::|.:||:.:
  Rat   306 KCEECGKAFASHLSLIQHKIGHTREKPYQCEECGKMFYCSSNLKQHQITHSQEKPYKCEVCGKVF 370

  Fly   371 RTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQH 435
            ||...|:.|.|.|:.:|||.|::||:.:....:|.:|||.||||:||.|:.|.|.:|..|.|::|
  Rat   371 RTCWQLSKHLRIHSGEKPYKCEECGKAFYTLSYLTQHKLGHTGEKPYKCEECGKTFYYPSVLKEH 435

  Fly   436 KISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKP 500
            ...|:|:|.:.|:.||.....:||..:|..:|:|.|.:||:.||.||:..|.|:.|..:|:|.||
  Rat   436 LAIHSGEKPYRCDECGKEFCTRSGRSRHQRIHTGEKPYKCEQCGKAFSTHSYLSHHKIVHTGHKP 500

  Fly   501 FKCEVCVKAFPTKKRLASHMRVHNKESP 528
            :|||.|.|.|....||..|.|:|::|:|
  Rat   501 YKCEECGKKFYYPSRLKEHQRIHSQENP 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	62/153 (41%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	58/135 (43%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	11/22 (50%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
LOC102549842	XP_006227879.1	KRAB	5..63	CDD:214630
		KRAB	5..44	CDD:279668
		C2H2 Zn finger	84..104	CDD:275368
		C2H2 Zn finger	112..132	CDD:275368
		C2H2 Zn finger	140..160	CDD:275368
		C2H2 Zn finger	168..188	CDD:275368
		C2H2 Zn finger	196..216	CDD:275368	3/4 (75%)
		C2H2 Zn finger	252..272	CDD:275368	3/22 (14%)
		C2H2 Zn finger	280..299	CDD:275368	4/25 (16%)
		COG5048	303..736	CDD:227381	96/244 (39%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	9/19 (47%)
		zf-H2C2_2	347..372	CDD:290200	10/24 (42%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		zf-H2C2_2	376..400	CDD:290200	10/23 (43%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		zf-H2C2_2	462..484	CDD:290200	10/21 (48%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
		C2H2 Zn finger	531..551	CDD:275368
		C2H2 Zn finger	559..579	CDD:275368
		C2H2 Zn finger	587..607	CDD:275368
		zf-H2C2_2	602..624	CDD:290200
		C2H2 Zn finger	615..635	CDD:275368
		C2H2 Zn finger	643..663	CDD:275368
		C2H2 Zn finger	671..691	CDD:275368
		C2H2 Zn finger	699..719	CDD:275368
		C2H2 Zn finger	727..747	CDD:275368
		C2H2 Zn finger	755..775	CDD:275368
		C2H2 Zn finger	783..803	CDD:275368
		zf-H2C2_2	798..820	CDD:290200
		C2H2 Zn finger	811..831	CDD:275368
		C2H2 Zn finger	839..859	CDD:275368
		C2H2 Zn finger	867..887	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910