DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and si:dkey-201g16.1

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_021331282.1	Gene:	si:dkey-201g16.1 / 101886555	ZFINID:	ZDB-GENE-120703-40	Length:	632	Species:	Danio rerio

Alignment Length:	286	Identity:	106/286 - (37%)
Similarity:	151/286 - (52%)	Gaps:	2/286 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 PYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGR 368
            |:.|..|.|:|.|...||.||..|..||.:.|.:|||....|.:...||:.||..||..|:.||:
Zfish   345 PFTCAQCGKSFSQSSHLNLHMMIHTGEKPFTCTQCGKSFSLLSSLNLHMMIHTGEKPFTCTQCGK 409

  Fly   369 FYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLR 433
            .:..:|:...|.|.|..:||:.|.|||:.::...||..|.:.||||:|:.|..|.|::..||.|.
Zfish   410 SFSLSSNRNKHMRIHTGEKPFTCAQCGKSFSQSSHLNLHMMIHTGEKPFTCTQCGKSFSQSSHLN 474

  Fly   434 QHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGE 498
            .|.::|||:|.|||..||...||.|....||.:|:|.|...|..||.:|:..|:||.|:.:|:||
Zfish   475 LHMMNHTGEKPFTCTQCGKSFSQSSNLNLHMRIHTGEKPFTCTQCGKSFSLLSSLNIHMMIHTGE 539

  Fly   499 KPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQSINPPSR-QAGAEGATGGGATGGSPTG 562
            |||.|..|.|:|.....|..|||:|..|.|...|...:|.:..|. ....:..||......:..|
Zfish   540 KPFTCTQCGKSFSQSSHLNKHMRIHTGEKPFMCTQCEKSFSQSSHLNKHMKIHTGEKPFTCTQCG 604

  Fly   563 GGATGGSATNLHITEVHEQPVSTSKV 588
            ...:..|:.|||: .:|....|.:::
Zfish   605 KSFSQSSSCNLHL-RIHTGEKSNNRI 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	59/146 (40%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	60/135 (44%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	8/19 (42%)
si:dkey-201g16.1	XP_021331282.1	C2H2 Zn finger	68..88	CDD:275368
		zf-H2C2_2	81..105	CDD:316026
		C2H2 Zn finger	96..116	CDD:275368
		C2H2 Zn finger	124..144	CDD:275368
		zf-H2C2_2	140..161	CDD:316026
		C2H2 Zn finger	152..172	CDD:275368
		zf-H2C2_2	164..188	CDD:316026
		C2H2 Zn finger	180..200	CDD:275368
		zf-H2C2_2	192..217	CDD:316026
		C2H2 Zn finger	208..228	CDD:275368
		COG5048	232..614	CDD:227381	101/268 (38%)
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	320..340	CDD:275368
		C2H2 Zn finger	348..368	CDD:275368	9/19 (47%)
		C2H2 Zn finger	376..396	CDD:275368	7/19 (37%)
		C2H2 Zn finger	404..424	CDD:275368	6/19 (32%)
		C2H2 Zn finger	432..452	CDD:275368	7/19 (37%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		C2H2 Zn finger	488..508	CDD:275368	8/19 (42%)
		C2H2 Zn finger	516..536	CDD:275368	8/19 (42%)
		C2H2 Zn finger	544..564	CDD:275368	8/19 (42%)
		C2H2 Zn finger	572..592	CDD:275368	3/19 (16%)
		C2H2 Zn finger	600..620	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910