DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and si:ch73-347e22.4

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_003200604.2	Gene:	si:ch73-347e22.4 / 100536830	ZFINID:	ZDB-GENE-140106-269	Length:	2461	Species:	Danio rerio

Alignment Length:	500	Identity:	110/500 - (22%)
Similarity:	188/500 - (37%)	Gaps:	105/500 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 SPNQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVD 173
            :|:.|.:..:...:.||||:.|     |..:.:|...|.|..:..:   .:.|:.....:|:::.
Zfish  1442 NPSSSVEISEFSSSQDSTEKTV-----NVAESSVMQKDVEFLKMGK---VVEVENSVVRVTKQLG 1498

  Fly   174 QD---------DELSEEEHQLAQSGDQQEEHITMESVHEFQPAEVEY-VTIKN--EFETIVTEED 226
            .|         |.||::    :.|..:::|....:.:...:.:...| :::|:  :.:.....::
Zfish  1499 NDPSDSSRSTTDPLSQD----SPSPKRKKEKNIEKPIRNLRVSSRLYEMSLKDSQKADKPSLSQN 1559

  Fly   227 EFEVMNDSGAHDAILDCQMIVIPAEGAIDEV-IGEETLELEG-------DGREEHLLPEAEDVCE 283
            ..||.|..|...         :|..|..:.: :.|:|...:|       :.:...::.......:
Zfish  1560 ATEVFNREGKTS---------LPMPGVAENLKLCEKTTVQDGMLANIKIENKATKVVKRRNRGRK 1615

  Fly   284 DEDFLEESLD---SAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHL 345
            .:.....|||   .:.||.....|..|..|..:||.......|.|.|..:|.|:|:.|||....|
Zfish  1616 RDRIKAPSLDQRLKSKPTEIVKKPLTCKYCGISFRHITAYTIHRRIHTGDKPYKCKICGKTFAQL 1680

  Fly   346 RNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTH-----AEKKP----------------- 388
            ...|.|.:.||......|..|...:.....|..|.:.|     |..:|
Zfish  1681 SKLKSHHIAHTQDTSFPCPCCNHRFMQKEDLLCHFKVHLKESKANSEPQKDLRSKRNALSNESSE 1745

  Fly   389 ----YNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEI 449
                |.|..|.:.:...|.|:.|..||..|:|.:|..|.|.:::.|||..|:.:|...|.:.|.|
Zfish  1746 AANNYRCLICKKNFVNQDKLQIHMQTHEMEKPLSCKDCGKNFWNPSSLTAHEKTHWPVKPYACSI 1810

  Fly   450 CGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKP-------------- 500
            ||.|.:|....|||...|:|.....|..|.|||   |:|:| :|:|...|.
Zfish  1811 CGKGFNQLRALKKHSQNHAGETPFSCFHCSHAF---SDLSA-LRMHQASKTCIARKNVEANSNIE 1871

  Fly   501 -----------------FKCEVCVKAFPTKKRLASHMRVHNKESP 528
                             |||::|.:.|....:...|::.|....|
Zfish  1872 GFIVSQGVDGQVNTPVFFKCQICKQLFRKWCQYTLHLQTHTSSPP 1916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	49/179 (27%)
		C2H2 Zn finger	307..327	CDD:275368	6/19 (32%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	4/19 (21%)
		COG5048	<387..523	CDD:227381	48/187 (26%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	9/22 (41%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	9/19 (47%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	9/53 (17%)
		C2H2 Zn finger	503..523	CDD:275368	4/19 (21%)
si:ch73-347e22.4	XP_003200604.2	C2H2 Zn finger	1642..1662	CDD:275368	6/19 (32%)
		zf-H2C2_2	1658..1679	CDD:290200	9/20 (45%)
		C2H2 Zn finger	1670..1690	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1698..1718	CDD:275368	4/19 (21%)
		zf-C2H2	1750..1772	CDD:278523	6/21 (29%)
		C2H2 Zn finger	1752..1772	CDD:275368	5/19 (26%)
		zf-H2C2_2	1765..1789	CDD:290200	9/23 (39%)
		C2H2 Zn finger	1780..1800	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1808..1828	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1836..1853	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1891..1911	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1919..1935	CDD:275368
		zf-C2H2_8	2038..2119	CDD:292531
		C2H2 Zn finger	2038..2058	CDD:275368
		zf-C2H2	2064..2086	CDD:278523
		C2H2 Zn finger	2066..2086	CDD:275368
		C2H2 Zn finger	2095..2115	CDD:275368
		C2H2 Zn finger	2123..2144	CDD:275368
		C2H2 Zn finger	2152..2172	CDD:275368
		C2H2 Zn finger	2180..2200	CDD:275368
		C2H2 Zn finger	2222..2242	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910