DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and LOC100498204

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_002934624.3	Gene:	LOC100498204 / 100498204	-ID:	-	Length:	1111	Species:	Xenopus tropicalis

Alignment Length:	674	Identity:	138/674 - (20%)
Similarity:	223/674 - (33%)	Gaps:	232/674 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NCRTCTRACKLHKPLQEEIDLGSEGSTTLASMLNYCTGLSFEPQDG-------AAMPQ--HICLH 68
            |.|.|      .|..|:|::               .||.|.:.|||       |..|:  ..|:.
Frog    28 NARNC------EKTNQDEME---------------NTGCSLDTQDGTNTTDRTAHKPEKRFFCID 71

  Fly    69 CLQLLEQAFNFKRMVI------DSDELL-------RLGLDEARCSSFHESQTHSP---NQSQQHD 117
            |    .::|..|..:|      ..::|.       |.||   :.|.....:||.|   |......
Frog    72 C----GKSFTRKSSLIVHQRIHTGEKLFMCTECGKRFGL---KSSLVRHLRTHIPKSLNICPDCG 129

  Fly   118 QQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLT--EEVDQDDELSE 180
            :....:.|..::..:. ..|:.....:.        ::.|:.     ..||.  :::.:.:||..
Frog   130 KGFSRYSSLFQHQKVH-FREKPYKCCHC--------KKSFSC-----NSFLEAHQKIHKVNELFN 180

  Fly   181 EEHQLAQSGDQ--QEEHITMESVHEFQPAEVEYVTIKNEFETIVTEEDEFEVMNDSGAHDAILDC 243
            .:.|:.|..||  .:||...::|       :|..:.....|:.:.||        .|...|.|
Frog   181 GKEQVEQISDQTKTKEHCRNDTV-------MELTSFPQYAESFIREE--------PGMRPAPL-- 228

  Fly   244 QMIVIPAEGAIDEVIGEETLELEGDGREEHL---LPEAEDVCEDEDFLEE--------SLDSAPP 297
                         :.|..|...|....|.::   .|:.:...:|....|.        |:.|...
Frog   229 -------------LTGSSTFSSETKHEEININSNSPDGKTEVDDTKGKESNLGHVTDLSVQSERT 280

  Fly   298 TAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKR-------LKHLR--------- 346
            |..|...::|..|.|.|.::..|..|.|:|..||.:.|.|||||       ::|:|
Frog   281 TQKEQKRFLCIDCGKRFTRKSSLIVHQRTHTGEKLFMCTECGKRFGLKSSLVRHIRTHTPKTLNI 345

  Fly   347 ------------NYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKK------------ 387
                        ::.:|..:|...||:.||.|.:.:..||.|.||:::|...|
Frog   346 CPECGKCFSRYTSFFQHQKSHRLQKPYTCSQCDKSFSRTSQLLVHQKSHRSGKEIDKIQHRENVR 410

  Fly   388 ----------------PYNCDQCGRGYAAFDHLRRHKLTHT------------------------ 412
                            .:.|.:|.:.:...:.|.||:..||
Frog   411 CQTKRRNVSRFDRFQETHACLECSKTFRQKESLLRHQRIHTVDQIDQFLPHPDTTDTKTTSTILK 475

  Fly   413 ----------------------------------------GERPYACDLCDKAYYDSSSLRQHKI 437
                                                    .|:...|..|.|::...|||..|:.
Frog   476 VIYEDEASVKPGNPKDGAKKSSNECKEISLERTGQAVSLNEEKRCLCIDCGKSFTRKSSLIVHQR 540

  Fly   438 SHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFK 502
            .|||:|.:.|..||.....||...:|:..|.....:.|..||..|:..|:|..|.|:|..:|.:|
Frog   541 IHTGEKLYMCTECGKRFGLKSSLVRHLRTHIPKTLNICPDCGKCFSRYSSLFQHQRVHKRDKQYK 605

  Fly   503 CEVCVKAFPTKKRLASHMRVHNKE 526
            |..|.|:|....:|..|.|.|..|
Frog   606 CSPCDKSFSRPSQLLLHQRNHKGE 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	19/98 (19%)
		COG5048	<297..451	CDD:227381	54/273 (20%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	9/47 (19%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	45/227 (20%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	9/86 (10%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	8/19 (42%)
		zf-H2C2_2	487..510	CDD:290200	9/22 (41%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
LOC100498204	XP_002934624.3	SUF4-like	66..>122	CDD:411020	13/62 (21%)
		COG5048	67..398	CDD:227381	77/381 (20%)
		C2H2 Zn finger	69..90	CDD:411020	5/24 (21%)
		C2H2 Zn finger	69..89	CDD:275368	5/23 (22%)
		C2H2 Zn finger	97..117	CDD:275368	4/22 (18%)
		C2H2 Zn finger	97..115	CDD:411020	4/20 (20%)
		C2H2 Zn finger	125..145	CDD:275368	1/19 (5%)
		C2H2 Zn finger	153..173	CDD:275368	3/32 (9%)
		C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		C2H2 Zn finger	318..338	CDD:275368	8/19 (42%)
		C2H2 Zn finger	346..366	CDD:275368	1/19 (5%)
		C2H2 Zn finger	374..394	CDD:275370	8/19 (42%)
		C2H2 Zn finger	430..450	CDD:275368	5/19 (26%)
		COG5048	522..>821	CDD:227381	38/108 (35%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		C2H2 Zn finger	550..570	CDD:275368	6/19 (32%)
		C2H2 Zn finger	578..598	CDD:275368	8/19 (42%)
		C2H2 Zn finger	606..626	CDD:275368	7/19 (37%)
		C2H2 Zn finger	661..681	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		C2H2 Zn finger	798..818	CDD:275368
		C2H2 Zn finger	826..846	CDD:275368
		SUF4-like	1019..>1070	CDD:411020
		C2H2 Zn finger	1022..1043	CDD:411020
		C2H2 Zn finger	1022..1042	CDD:275368
		C2H2 Zn finger	1050..1070	CDD:411020
		C2H2 Zn finger	1050..1070	CDD:275368
		C2H2 Zn finger	1077..1097	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910