DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and glis3

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_002934220.1	Gene:	glis3 / 100496527	XenbaseID:	XB-GENE-984727	Length:	922	Species:	Xenopus tropicalis

Alignment Length:	330	Identity:	71/330 - (21%)
Similarity:	121/330 - (36%)	Gaps:	105/330 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 SAPPTAGEALP--------------YVC--TVCQKAFRQQCRLNQHM-RSHVDEKQ---YECEEC 338
            |.|||  :.:|              :.|  ..|...:.||..|.:|: :.|:|:::   :.|...
Frog   468 SLPPT--DTVPLLEEEGEIDDFNGKHCCRWIDCSSMYEQQEELVRHIEKVHIDQRKGEDFACFWA 530

  Fly   339 GKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSS---LAVHKRTHAEKKPYNC--DQCGRGY 398
            |                          |.|.|:..::   |.:|.|.|:.:||..|  :.|.:.:
Frog   531 G--------------------------CPRRYKPFNARYKLLIHMRVHSGEKPNKCTFEGCKKAF 569

  Fly   399 AAFDHLRRHKLTHTGERPYACDL--CDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYK 461
            :..::|:.|..:||||:||.|..  |.||:.:||...:|:.:|...|.:.|:|.|
Frog   570 SRLENLKIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPG---------- 624

  Fly   462 KHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKE 526
                            |...:|..|:|..||:.||.          |....:|:|.|  |....:
Frog   625 ----------------CSKRYTDPSSLRKHVKAHSS----------KDQQARKKLRS--RTDLDQ 661

  Fly   527 SPVTATVAVQSINP-PSRQAGAEGATG-----------GGATGGSPTGGGATGGSATNLHITEVH 579
            ..::..:.:|.:.| .|.|..:|.:.|           |.....:.:....|.|......:...|
Frog   662 EILSDCLTIQPLQPATSPQDPSESSMGRSPGPVHDVYPGAMFSSTHSSRSGTAGGTVPPPLPPSH 726

  Fly   580 EQPVS 584
            ..|.|
Frog   727 PSPAS 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	43/180 (24%)
		C2H2 Zn finger	307..327	CDD:275368	6/22 (27%)
		C2H2 Zn finger	335..355	CDD:275368	2/19 (11%)
		C2H2 Zn finger	363..383	CDD:275368	6/22 (27%)
		COG5048	<387..523	CDD:227381	37/139 (27%)
		C2H2 Zn finger	391..411	CDD:275368	4/21 (19%)
		zf-H2C2_2	403..426	CDD:290200	11/24 (46%)
		C2H2 Zn finger	419..439	CDD:275368	7/21 (33%)
		C2H2 Zn finger	447..467	CDD:275368	3/19 (16%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		zf-H2C2_2	487..510	CDD:290200	6/22 (27%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
glis3	XP_002934220.1	C2H2 Zn finger	497..516	CDD:275368	5/18 (28%)
		C2H2 Zn finger	527..552	CDD:275368	8/50 (16%)
		SFP1	<549..643	CDD:227516	32/119 (27%)
		C2H2 Zn finger	560..582	CDD:275368	4/21 (19%)
		C2H2 Zn finger	590..612	CDD:275368	7/21 (33%)
		C2H2 Zn finger	620..642	CDD:275368	9/47 (19%)
		Atrophin-1	632..>855	CDD:367360	23/112 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910