DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and prdm6

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_002931772.5	Gene:	prdm6 / 100494529	XenbaseID:	XB-GENE-854907	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	288	Identity:	69/288 - (23%)
Similarity:	113/288 - (39%)	Gaps:	65/288 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   254 IDEVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQC 318
            ||...|.|.|....|..........:.:.:||:.      :.|....||:....|:  ::|.:..
Frog   299 IDIPRGTELLVWYNDSYTSFFGIPLQCIAQDENL------NVPSPVIEAMSRQDTL--QSFNKNG 355

  Fly   319 RLNQHMRSHVDEKQYECEECGKRLKHLRNYK--------EHMLTHTNVKPHQCSICGRFYRTTSS 375
            :|:..::..:...|..|.         |||.        :......|||..         |..:|
Frog   356 KLSSSLQRSLVFPQTPCN---------RNYSLLEKSGPLDTGYNQINVKNQ---------RVLAS 402

  Fly   376 LAVHKRTHAEKKPYNCDQCGRGYAAFDH---LRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKI 437
            .....:.::|...::..:||:.:..|..   |:.|..|...:|||.|..|.:::...|.||.|.:
Frog   403 PTSTSQLNSEFSDWHLWKCGQCFKTFTQRILLQMHVCTQNPDRPYQCGHCSQSFSQPSELRNHVV 467

  Fly   438 SHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFK 502
            :|:..:.|                            ||..||.||...:.||.|:|.|:||||||
Frog   468 THSSDRPF----------------------------KCGYCGRAFAGATTLNNHIRTHTGEKPFK 504

  Fly   503 CEVCVKAFPTKKRLASHMRVHNKESPVT 530
            ||.|.::|....:|:.|.|:.|:..|:|
Frog   505 CERCDRSFTQATQLSRHQRMPNECKPIT 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	33/164 (20%)
		C2H2 Zn finger	307..327	CDD:275368	3/19 (16%)
		C2H2 Zn finger	335..355	CDD:275368	4/27 (15%)
		C2H2 Zn finger	363..383	CDD:275368	2/19 (11%)
		COG5048	<387..523	CDD:227381	41/138 (30%)
		C2H2 Zn finger	391..411	CDD:275368	5/22 (23%)
		zf-H2C2_2	403..426	CDD:290200	8/25 (32%)
		C2H2 Zn finger	419..439	CDD:275368	6/19 (32%)
		C2H2 Zn finger	447..467	CDD:275368	0/19 (0%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	14/22 (64%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
prdm6	XP_002931772.5	PR-SET_PRDM6	191..319	CDD:380968	6/19 (32%)
		COG5048	<348..530	CDD:227381	55/229 (24%)
		C2H2 Zn finger	421..441	CDD:275368	5/19 (26%)
		C2H2 Zn finger	449..469	CDD:275368	6/19 (32%)
		zf-C2H2	475..497	CDD:395048	11/49 (22%)
		C2H2 Zn finger	477..497	CDD:275368	9/19 (47%)
		zf-H2C2_2	490..514	CDD:404364	15/23 (65%)
		C2H2 Zn finger	505..523	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910