DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and LOC100493522

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_002943633.3	Gene:	LOC100493522 / 100493522	-ID:	-	Length:	837	Species:	Xenopus tropicalis

Alignment Length:	537	Identity:	146/537 - (27%)
Similarity:	212/537 - (39%)	Gaps:	106/537 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 GLSFEPQDGAAMPQHICLHCLQLLEQAFNFKRMVIDSDELLRLGLDEARCSSFHESQT----HSP 110
            |.:...:.|...|...|..|:                     ||   ..| ..|.:.|    |:|
Frog    84 GYTVTKKSGDGAPPQTCTDCM---------------------LG---GAC-RHHVTPTVGALHAP 123

  Fly   111 NQSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQD 175
            ..:.|.:..::..:.....:.:            |..|:|.:.:.:.|....|:.|.|..:....
Frog   124 GSALQKENAKRILELISNIIQL------------LTGEVAVQWKEVPASVTMEDWETLKAKTAAY 176

  Fly   176 DELSEEEHQLAQSGDQQE----EHITMESVHEFQPAEVEYVT----------------------- 213
            .:.:.|..|.|...||:|    |..|:...:.|..:|.|...
Frog   177 RDTNRESDQRADWEDQREVKELEEWTLHGTNGFPRSESEAADSPQGQNLPNSPPTAPQSPPHCIS 241

  Fly   214 --IKNE----------------FETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAID---EV 257
              ||.|                ...|..|.|..|     |...::  |.::..|.:|...   |.
Frog   242 HGIKQEQAVWEGGEGSDPVAQPVHDIKQEADCLE-----GGRKSV--CNVVTEPTQGGQTRGAES 299

  Fly   258 IGEETLELEGDGREEHLLPEAED--VCEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRL 320
            .|.::|   ..|.|....|....  :..|.|.   ....:|.|.|:.  :.|:.|.|.|.::.:|
Frog   300 KGNKSL---ATGLEAPTSPGVTPKLIISDRDL---GGYESPQTGGKT--FTCSECGKGFPRRAKL 356

  Fly   321 NQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAE 385
            .:|.|.|..||.:.|:||||.........||..||...||..|:.|||.:...|.|.||.|||..
Frog   357 IEHFRIHTGEKPFACDECGKCFTRRAKLVEHQRTHMGEKPFTCTECGRGFTCRSKLIVHHRTHTG 421

  Fly   386 KKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEIC 450
            :||::|.:|.:.:|....|.||...||||||::|..|.|::...|:|.||.|.|||:|.|||..|
Frog   422 EKPFSCSECKKSFACHTELYRHFRIHTGERPFSCSECGKSFRLKSNLIQHSIIHTGEKPFTCTEC 486

  Fly   451 GVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKR 515
            |.|.:.:|....|...|:|.|...|..||.:|...:.|..|.|:|:|||||.|..|.|:|..:..
Frog   487 GRGFTCRSKLIVHCRTHTGEKPFSCSECGKSFPCHTELYRHFRIHTGEKPFSCSECGKSFRLRSN 551

  Fly   516 LASHMRVHNKESPVTAT 532
            |..|..:|..|.|.|.|
Frog   552 LIQHSIIHTGEKPFTCT 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	5/40 (13%)
		COG5048	<297..451	CDD:227381	63/153 (41%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	9/19 (47%)
		COG5048	<387..523	CDD:227381	56/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	8/19 (42%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
LOC100493522	XP_002943633.3	C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		COG5048	367..818	CDD:227381	84/202 (42%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		C2H2 Zn finger	399..419	CDD:275368	9/19 (47%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	455..475	CDD:275368	8/19 (42%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		C2H2 Zn finger	567..587	CDD:275368	1/2 (50%)
		C2H2 Zn finger	595..615	CDD:275368
		C2H2 Zn finger	632..652	CDD:275368
		C2H2 Zn finger	660..680	CDD:275368
		C2H2 Zn finger	688..708	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	744..764	CDD:275368
		C2H2 Zn finger	772..792	CDD:275368
		C2H2 Zn finger	800..820	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910