DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and prdm14

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_002937124.2	Gene:	prdm14 / 100490605	XenbaseID:	XB-GENE-954695	Length:	536	Species:	Xenopus tropicalis

Alignment Length:	306	Identity:	76/306 - (24%)
Similarity:	124/306 - (40%)	Gaps:	74/306 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 IVIPAEGAIDEVIGEETL--ELEGDGREEHLL------------------PEAEDV----CEDED 286
            :|.|:|   .:..|:.:|  |:..:||..|.:                  ||.:::    ||.|.
Frog   250 VVHPSE---IKTYGDNSLMWEIFDEGRLSHFIDGKGAAGNWMSRVNCARFPEEQNLIALQCEGEI 311

  Fly   287 FLEESLDSAP------------------PTAGEAL-----PYVCTVCQKAFRQQCRLNQHMRSHV 328
            :.|...:..|                  |.:.:.|     ||                |......
Frog   312 YYESCKEILPGQELLVWYGDSYLQFLGIPLSLKGLGEGRPPY----------------QPTEEPA 360

  Fly   329 DEKQYECEECGKRLKHLRNYKEHMLTHTNV-----KPHQCSICGRFYRTTSSLAVH-KRTHAEKK 387
            ..:.|:||.|||...: |.|::..|.:|..     :...|.:|.|.:.....|.:| ...|.:.:
Frog   361 AAEGYKCERCGKVFAY-RYYRDKHLKYTRCVDQGDRKFPCHLCNRSFEKRDRLRIHILHVHEKHR 424

  Fly   388 PYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGV 452
            |:.|..||:.::....|.:|...|:|||||.|..|:||:..||.||.|...|:|:|.|.|:.||.
Frog   425 PHKCTVCGKSFSQSSSLNKHMRVHSGERPYKCVYCNKAFTASSILRTHIRQHSGEKPFKCKHCGK 489

  Fly   453 GLSQKSGYKKHM-MVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSG 497
            ..:..:.:..|: ..|:..|.:.|.:||..|........|:::|||
Frog   490 AFASHAAHDSHVRRTHTKEKGYICSLCGKTFLEMEEFRYHMQIHSG 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	47/164 (29%)
		C2H2 Zn finger	307..327	CDD:275368	1/19 (5%)
		C2H2 Zn finger	335..355	CDD:275368	8/19 (42%)
		C2H2 Zn finger	363..383	CDD:275368	5/20 (25%)
		COG5048	<387..523	CDD:227381	39/112 (35%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	419..439	CDD:275368	9/19 (47%)
		C2H2 Zn finger	447..467	CDD:275368	4/20 (20%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		zf-H2C2_2	487..510	CDD:290200	4/11 (36%)
		C2H2 Zn finger	503..523	CDD:275368
prdm14	XP_002937124.2	PR-SET_PRDM14	210..342	CDD:380975	17/94 (18%)
		C2H2 Zn finger	399..418	CDD:275368	5/18 (28%)
		zf-C2H2	426..448	CDD:333835	5/21 (24%)
		C2H2 Zn finger	428..448	CDD:275368	5/19 (26%)
		SFP1	<445..529	CDD:227516	29/83 (35%)
		C2H2 Zn finger	456..476	CDD:275368	9/19 (47%)
		zf-H2C2_2	469..493	CDD:372612	10/23 (43%)
		C2H2 Zn finger	484..505	CDD:275368	4/20 (20%)
		C2H2 Zn finger	513..533	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910