DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and LOC100486443

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_031759800.1	Gene:	LOC100486443 / 100486443	-ID:	-	Length:	1764	Species:	Xenopus tropicalis

Alignment Length:	665	Identity:	153/665 - (23%)
Similarity:	245/665 - (36%)	Gaps:	199/665 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 SSFHESQTHSPNQS-QQH-------DQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRR- 155
            :|...:||...:|| ..|       |:.|:|...::|        .::||:...:.|....|.|
Frog   390 ASVGAAQTQRSSQSWGDHPAAAVGGDEHQEAETRSQE--------TKRENIEREERECLAPDSRE 446

  Fly   156 ---------IFAMTVDEEEEFLTEEV------------DQDDELSEEEHQLAQ------------ 187
                     :...|...:..:...:|            |.:|....|:.|.::
Frog   447 CNSNCCGLTLSNGTQTAQHHYAHHDVPPGSAGANENSHDGNDTCVSEQRQPSEASGPGQKTETQR 511

  Fly   188 ----SGDQQEEHITMESVHEFQPAEVEY--VTIKNEFETI----------VTEEDEF--EVMNDS 234
                |.:.|..|:..::|...:..||..  .:.:|..|.:          |:..::|  ::.:.|
Frog   512 HFGVSSEVQSGHMISQTVCPMRNNEVSQNPGSARNIAEHVEPWAPPGKCPVSSSNDFRLDLSSSS 576

  Fly   235 GAHDAILDCQMIVIPAEG------AIDEVIGEETLELEG----------DGRE-----EHLLPEA 278
            |.          :.|.||      :.|:...:.|.:..|          .|.|     :|....:
Frog   577 GK----------ISPVEGQQMEARSTDQCFLDSTSKQNGAVPNPDQCIKAGEEYGVGYKHAAQLS 631

  Fly   279 EDVCEDEDFLEESLDSAPPT-----AGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEEC 338
            |.|...::|.|.:  .|.|.     :.|..||:|.||.|.|.:...|..|...|..||.:.|::|
Frog   632 EHVTHQKEFQEAT--CASPVKKTRCSSEREPYMCKVCGKVFTRHSTLMHHHSIHTGEKPFVCQQC 694

  Fly   339 GKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDH 403
            ||..:...|.|.|..:||..||:.|..||:.:..|||||||:|||.:::|::|..||:.:.....
Frog   695 GKCFRDANNLKVHTRSHTKEKPYTCLECGKRFGQTSSLAVHQRTHTDERPFHCTDCGKSFTDRST 759

  Fly   404 LRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMV-- 466
            |.:|:..||||:|::|..|.|.:...:.:.:|:..|||::.|.|.:||.....:|...||..:
Frog   760 LLQHQRIHTGEKPFSCSFCGKRFTQQAHIGRHEKIHTGERPFGCTVCGKRFIDRSKLIKHERIHT 824

  Fly   467 ----------------------------------------------------------------- 466

Frog   825 RVKVCFGGSSEEEELIPRDITKARSQLVKPENLATEQPIRAEAVLGLWGTDIEGTNTVEMGLISN 889

  Fly   467 -----------------HSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKK 514
                             |||.|.:.|..||..|.:.|.|..|...|||::||.|..|.:.|..|:
Frog   890 GSRKPPNKLQLETHRKSHSGAKPYVCKDCGKVFNWASKLAEHQVTHSGKRPFPCTECWRRFTRKE 954

  Fly   515 RLASHMRVHNKESPVTATVAVQSINPPS---RQAGAEGATGGGATGGSPTGGGATGGSATNLHIT 576
            .|..|.:||..|.|.|.....:|.:...   |...|:.|.|||.:.|:   |.....|...|.:|
Frog   955 HLLRHRKVHTGEKPFTCPECGKSFSRKEHLVRHREAKAAVGGGHSNGT---GSVPDISIIKLEVT 1016

  Fly   577 ---EVHEQPVSTSKV 588
               |..|.|.|..::
Frog  1017 SDIEGEEPPRSAEEL 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	58/158 (37%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	11/19 (58%)
		COG5048	<387..523	CDD:227381	47/219 (21%)
		C2H2 Zn finger	391..411	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	4/19 (21%)
		C2H2 Zn finger	447..467	CDD:275368	6/103 (6%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	9/22 (41%)
		C2H2 Zn finger	503..523	CDD:275368	6/19 (32%)
LOC100486443	XP_031759800.1	KRAB	8..47	CDD:396083
		eNOPS_SF	291..>324	CDD:414955
		C2H2 Zn finger	663..683	CDD:275368	7/19 (37%)
		COG5048	687..>987	CDD:227381	78/299 (26%)
		C2H2 Zn finger	691..711	CDD:275368	7/19 (37%)
		C2H2 Zn finger	719..739	CDD:275368	11/19 (58%)
		C2H2 Zn finger	747..767	CDD:275368	5/19 (26%)
		C2H2 Zn finger	775..795	CDD:275368	4/19 (21%)
		C2H2 Zn finger	803..823	CDD:275368	6/19 (32%)
		C2H2 Zn finger	915..935	CDD:275368	7/19 (37%)
		COG5048	938..1386	CDD:227381	29/97 (30%)
		C2H2 Zn finger	943..963	CDD:275368	6/19 (32%)
		C2H2 Zn finger	971..988	CDD:275368	2/16 (13%)
		C2H2 Zn finger	1118..1138	CDD:275368
		C2H2 Zn finger	1146..1166	CDD:275368
		C2H2 Zn finger	1174..1194	CDD:275368
		C2H2 Zn finger	1202..1222	CDD:275368
		C2H2 Zn finger	1230..1250	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
		C2H2 Zn finger	1286..1306	CDD:275368
		COG5048	1292..1723	CDD:227381
		C2H2 Zn finger	1314..1334	CDD:275368
		C2H2 Zn finger	1342..1362	CDD:275368
		C2H2 Zn finger	1370..1390	CDD:275368
		C2H2 Zn finger	1398..1418	CDD:275368
		C2H2 Zn finger	1426..1446	CDD:275368
		C2H2 Zn finger	1454..1472	CDD:275368
		C2H2 Zn finger	1567..1587	CDD:275368
		C2H2 Zn finger	1595..1615	CDD:275368
		C2H2 Zn finger	1623..1643	CDD:275368
		C2H2 Zn finger	1651..1671	CDD:275368
		C2H2 Zn finger	1679..1699	CDD:275368
		C2H2 Zn finger	1707..1727	CDD:275368
		zf-H2C2_2	1720..1744	CDD:404364
		C2H2 Zn finger	1735..1754	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910