DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and LOC100485704

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_017950222.2	Gene:	LOC100485704 / 100485704	-ID:	-	Length:	959	Species:	Xenopus tropicalis

Alignment Length:	521	Identity:	139/521 - (26%)
Similarity:	224/521 - (42%)	Gaps:	71/521 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QHICLHCLQLLEQAFNF-KRMVIDSD----------ELLRLGLDEARCSSFHESQTHSPNQSQQH 116
            :.:|..|.:.|:..|:. :.|.|.|:          :..||    ..|...|: :||:..:....
Frog   374 KEVCSTCGKQLKSKFSLNQHMKIHSNIKPFACSECSKSFRL----KACLQLHQ-RTHTGEKPYTC 433

  Fly   117 DQQQQAFDSTEEYVMIEMLNEEQENVA--NLDEEL-AEEDRRIFAMTVDEEEEFLTEEVDQDDEL 178
            ::.:::|....:.....:::..::..|  ...:.| ::|..|...:....|:.|...|.|:...:
Frog   434 NECRKSFAQVGQLKAHYLIHTGEKPFACSECGKGLRSKEALRAHLLCHTGEKPFSCSECDKSFRV 498

  Fly   179 --SEEEHQLAQSGDQ-----------------QEEHITMESVHEFQPAEV------EYVTIKNEF 218
              |.:.||...:|::                 :...:|...:..|:.:|.      :...||::|
Frog   499 KSSLQIHQRVHTGEKPFECKECGKCFRIKTNFKSHQLTHTGIKRFECSECGMQFSHKNGLIKHQF 563

  Fly   219 ETIVTEEDEFEVM--NDSGAHDAILDCQMIVIPAEGAIDEVIGEETLELEGDGREEHLLPEAEDV 281
              |.|.|..||.:  ..|.:....|:...:|                   ..|.:.::..|....
Frog   564 --IHTGERPFECVTCGKSFSRKFTLNKHQLV-------------------HTGEKPYVCTECGMG 607

  Fly   282 CEDEDFLEESLDSAPPTAGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLR 346
            .:|:..|...|.:....||  :|  ||.|.|.|..:..|..||::|...|::.|:||||......
Frog   608 YKDKRSLVAHLRTHTGEAG--IP--CTECGKTFLSEKNLKFHMQTHTGVKRFACKECGKSFSKKS 668

  Fly   347 NYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTH 411
            .::.|.|.|..:||.||:.||:.:|..|...:|:..|..:||:.|.:||.||.....|:.|.|.|
Frog   669 QFETHKLMHAGIKPFQCAECGKLFRHKSYFKIHQLIHTGEKPFVCPECGLGYTTKTSLKNHLLCH 733

  Fly   412 TGERPYACDLCDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCD 476
            |||:|:||..|.|.|....||.:|..:|..:|.|.|..||..|..|.|.:||.:.|:|.:.|.|.
Frog   734 TGEKPFACKECGKKYLQQRSLNKHMETHRAEKPFECSECGKKLRSKYGLQKHQLTHTGERPHVCT 798

  Fly   477 VCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQSINPP 541
            .||..|.....|:.|:|.|:||.|||||.|.|.|.:...|..|...|..|.|.|.....:|....
Frog   799 ECGKRFRDRYQLSIHLRTHTGETPFKCEECGKVFASSTNLQVHKVTHTGEKPFTCEKCGKSFTQK 863

  Fly   542 S 542
            |
Frog   864 S 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	7/38 (18%)
		COG5048	<297..451	CDD:227381	58/153 (38%)
		C2H2 Zn finger	307..327	CDD:275368	8/19 (42%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	57/135 (42%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	419..439	CDD:275368	7/19 (37%)
		C2H2 Zn finger	447..467	CDD:275368	8/19 (42%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	13/22 (59%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
LOC100485704	XP_017950222.2	COG5048	<210..417	CDD:227381	9/46 (20%)
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	258..278	CDD:275368
		C2H2 Zn finger	308..328	CDD:275368
		C2H2 Zn finger	336..356	CDD:275368
		C2H2 Zn finger	377..397	CDD:275368	5/19 (26%)
		COG5048	401..836	CDD:227381	124/464 (27%)
		C2H2 Zn finger	405..425	CDD:275368	4/24 (17%)
		C2H2 Zn finger	433..453	CDD:275368	1/19 (5%)
		C2H2 Zn finger	461..481	CDD:275368	3/19 (16%)
		C2H2 Zn finger	489..509	CDD:275368	5/19 (26%)
		C2H2 Zn finger	517..537	CDD:275368	0/19 (0%)
		C2H2 Zn finger	545..565	CDD:275368	4/21 (19%)
		C2H2 Zn finger	573..593	CDD:275368	3/38 (8%)
		C2H2 Zn finger	601..621	CDD:275368	4/19 (21%)
		C2H2 Zn finger	629..649	CDD:275368	8/19 (42%)
		C2H2 Zn finger	657..677	CDD:275368	7/19 (37%)
		C2H2 Zn finger	685..705	CDD:275368	6/19 (32%)
		C2H2 Zn finger	713..733	CDD:275368	8/19 (42%)
		C2H2 Zn finger	741..761	CDD:275368	7/19 (37%)
		C2H2 Zn finger	769..789	CDD:275368	8/19 (42%)
		C2H2 Zn finger	797..817	CDD:275368	7/19 (37%)
		C2H2 Zn finger	825..845	CDD:275368	7/19 (37%)
		zf-H2C2_2	837..862	CDD:404364	7/24 (29%)
		C2H2 Zn finger	853..873	CDD:275368	2/12 (17%)
		zf-C2H2	878..900	CDD:395048
		C2H2 Zn finger	880..900	CDD:275368
		zf-H2C2_2	892..915	CDD:404364
		C2H2 Zn finger	908..928	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910