DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and si:dkey-33c14.6

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_002660736.2	Gene:	si:dkey-33c14.6 / 100333245	ZFINID:	ZDB-GENE-131120-188	Length:	556	Species:	Danio rerio

Alignment Length:	481	Identity:	136/481 - (28%)
Similarity:	213/481 - (44%)	Gaps:	64/481 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 EYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQ 192
            |::.:|:       |.::|.||    ||:    .||:.|   ||.|:|....:||.|.:..|
Zfish     2 EFIKMEI-------VDSIDAEL----RRV----KDEDAE---EEEDRDHTEIKEERQESSDG--- 45

  Fly   193 EEHITMESVHEFQPAEVEYV-TIKNEFETIV-TEE--DEFEVMNDSGAHDAILDCQMIVIPAEGA 253
                  :...:..|....:: .:.:|..||: |.|  :...|...|......:|..|.:...|..
Zfish    46 ------KDCIKINPPGKSFIHKLDSEDPTIIHTSEKPNTCPVCGKSFTCKGSVDVHMRIHTGERP 104

  Fly   254 IDEVIGEETLELEG---------DGREEHLLPEAEDVCEDEDFLEESLDSAPPTAGEALPYVCTV 309
            ...:...::...:|         .|.:.:..|:    ||.....:.||........|..|::|..
Zfish   105 YACIQCGKSFTCKGTLTCHVRTHTGEKPYTCPQ----CEKSFTHKASLRYHMRLHTEDGPFICGQ 165

  Fly   310 CQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTS 374
            |.|:|.|:..|..|::.|...|.:.||.|||......:.|.|...||..||:.||.||:.:....
Zfish   166 CGKSFAQEEYLKHHVKIHYAGKPFTCELCGKGFTCKGSLKIHTRIHTGEKPYTCSHCGKSFTNKG 230

  Fly   375 SLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQHKISH 439
            :|.:|...|.||....|.|||:.:...::|:.|...||||:|::|..|.|.:.....|:.|..:|
Zfish   231 NLKIHANMHTEKSALTCVQCGKSFTHEENLKSHMRIHTGEKPFSCHQCGKRFARKIILQNHVKTH 295

  Fly   440 TGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCE 504
            :|:|.:||..||...:.:...|:||..|:|.|...|..||.:||...||..|:|:|:||||.||.
Zfish   296 SGEKPYTCHQCGKRFTDRGYIKRHMRSHTGEKPFICPQCGKSFTHKGNLKIHIRIHTGEKPSKCP 360

  Fly   505 VCVKAFPTKKRLASHMRVHNKESPVTATVAVQS------INPPSRQAGAEGATGGGATGGS--PT 561
            .|.|:|..|.:|..|||:|:.|.|....:..::      :...||       |..|....|  ..
Zfish   361 ECEKSFTHKGQLKDHMRIHSGEKPYACPLCAKTFKCKGHLKTHSR-------THSGVKPYSCLQC 418

  Fly   562 GGGATGGSATNLHI-----TEVHEQP 582
            |...|...:.|:|:     .::||.|
Zfish   419 GKSFTVRKSLNVHLKYHSGEKLHECP 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	52/153 (34%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		COG5048	<387..523	CDD:227381	53/135 (39%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	13/22 (59%)
		C2H2 Zn finger	503..523	CDD:275368	9/19 (47%)
si:dkey-33c14.6	XP_002660736.2	C2H2 Zn finger	55..71	CDD:275368	3/15 (20%)
		C2H2 Zn finger	79..99	CDD:275368	4/19 (21%)
		zf-H2C2_2	91..116	CDD:290200	3/24 (13%)
		COG5048	103..503	CDD:227381	106/353 (30%)
		C2H2 Zn finger	107..127	CDD:275368	1/19 (5%)
		zf-H2C2_2	120..144	CDD:290200	4/27 (15%)
		C2H2 Zn finger	135..155	CDD:275368	5/23 (22%)
		C2H2 Zn finger	163..183	CDD:275368	7/19 (37%)
		C2H2 Zn finger	191..211	CDD:275368	7/19 (37%)
		zf-H2C2_2	203..228	CDD:290200	10/24 (42%)
		C2H2 Zn finger	247..267	CDD:275368	6/19 (32%)
		zf-H2C2_2	259..284	CDD:290200	10/24 (42%)
		C2H2 Zn finger	275..295	CDD:275368	5/19 (26%)
		zf-H2C2_2	288..311	CDD:290200	9/22 (41%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		zf-H2C2_2	317..340	CDD:290200	10/22 (45%)
		C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		zf-H2C2_2	343..368	CDD:290200	14/24 (58%)
		C2H2 Zn finger	359..379	CDD:275368	9/19 (47%)
		C2H2 Zn finger	387..407	CDD:275368	2/26 (8%)
		C2H2 Zn finger	415..435	CDD:275368	4/19 (21%)
		C2H2 Zn finger	443..463	CDD:275368	1/2 (50%)
		C2H2 Zn finger	471..491	CDD:275368
		C2H2 Zn finger	499..519	CDD:275368
		zf-H2C2_2	511..536	CDD:290200
		C2H2 Zn finger	527..547	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910