DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and znf865

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001120386.1	Gene:	znf865 / 100145461	XenbaseID:	XB-GENE-5959428	Length:	942	Species:	Xenopus tropicalis

Alignment Length:	528	Identity:	137/528 - (25%)
Similarity:	210/528 - (39%)	Gaps:	139/528 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 SQTHSPNQ------SQQHDQQ------QQAFDST---EEYVMIEMLNEEQENVANLDEEL----- 149
            |.:.||::      :||.:.|      |..||||   .::.::: |:..|....||...|
Frog    84 SSSLSPSKKPDIATTQQFNNQPPITTTQTIFDSTFNAAQWGIVD-LSSHQHLFNNLKRSLPVAQQ 147

  Fly   150 --AEE----------------DRRIFAMTVDEEEEFLTEEVDQDDELSEEEHQLAQSGDQQEEHI 196
              ||:                ||| |..||.:      :...|...|  .:|.|..:|::..|..
Frog   148 LPAEDENKDDKNYFRRLKYLIDRR-FPCTVCQ------KSFKQSSHL--VQHMLVHTGERPYECN 203

  Fly   197 TMESVHEFQPAEVEYVTIKNEFETIV------TEEDEFEVMNDSGAHDAILDCQMIVIPAEGAID 255
            |....:             |...:::      .||.|.||.|.....|........|:.|..|..
Frog   204 TCGRTY-------------NHISSLIRHRRCHKEETEAEVTNSVPPPDGEAAAAAAVVAAAAAAM 255

  Fly   256 EVIGEETLELEGDGREEHLLPEAEDVCEDEDFLEESLDSAP-PTAGEALPYVCTVCQKAFRQQCR 319
            ......:.|:...|.|:                     |.| |..|   |:.||:|.|.|::|..
Frog   256 SEAAAGSAEMPVTGSEQ---------------------SIPLPQDG---PFTCTLCWKVFKKQSH 296

  Fly   320 LNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRFYRTTSSLAVHKRTHA 384
            |:||...|..||.:.|..|.|......:.|.|:.||::....||.:||:.:|.||.|..|:.||.
Frog   297 LHQHQIIHTGEKPFSCSVCAKSFNRRESLKRHVKTHSDSMKVQCEVCGKSFRDTSYLLKHQATHT 361

  Fly   385 EKKP-YNCDQCGRGYAAFDHLRRHKLTH------------------------------------- 411
            .::| |.|:.||:.|||...|.|||..|
Frog   362 GERPDYKCELCGKSYAAPQSLLRHKQVHEQGLALQQPMVQQQQPLSEVIKEPTSSVTIEAASLLG 426

  Fly   412 ---TGERPYACDLCDK--AYYDSSSLRQ-HKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGV 470
               :...|.|..:..|  :::..|||:: ..:.:...|.|.|.:||.|..::...|:|..:|:|.
Frog   427 TDVSNVGPAAISVIGKIGSFFSQSSLQKPPSVINNANKNFCCNVCGRGFGRRETLKRHERIHTGE 491

  Fly   471 KAHKCDVCGHAFTFTSNLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAV 535
            |.|:|.|||..|..:.:|..|..:|:.|:|:|||:|.|.|...:.|..|.::|..:.|  .|||.
Frog   492 KPHQCSVCGKRFRESFHLTKHHVVHTRERPYKCELCGKVFGYPQSLTRHKQIHRLQLP--CTVAT 554

  Fly   536 QSINPPSR 543
            .:: ||.|
Frog   555 GTL-PPDR 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	55/197 (28%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	49/179 (27%)
		C2H2 Zn finger	391..411	CDD:275368	10/19 (53%)
		zf-H2C2_2	403..426	CDD:290200	8/64 (13%)
		C2H2 Zn finger	419..439	CDD:275368	4/22 (18%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..510	CDD:290200	10/22 (45%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
znf865	NP_001120386.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..106		6/21 (29%)
		COG5048	156..616	CDD:227381	119/455 (26%)
		C2H2 Zn finger	174..194	CDD:275368	6/27 (22%)
		C2H2 Zn finger	202..220	CDD:275368	2/30 (7%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		C2H2 Zn finger	312..332	CDD:275368	5/19 (26%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	369..389	CDD:275370	10/19 (53%)
		COG5048	448..928	CDD:227381	41/117 (35%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		zf-H2C2_2	481..503	CDD:290200	10/21 (48%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		C2H2 Zn finger	524..544	CDD:275368	7/19 (37%)
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
		C2H2 Zn finger	680..700	CDD:275368
		C2H2 Zn finger	708..728	CDD:275368
		C2H2 Zn finger	736..756	CDD:275368
		zf-H2C2_2	749..773	CDD:290200
		C2H2 Zn finger	764..784	CDD:275368
		C2H2 Zn finger	792..812	CDD:275368
		C2H2 Zn finger	820..840	CDD:275368
		zf-H2C2_2	832..855	CDD:290200
		C2H2 Zn finger	848..868	CDD:275368
		C2H2 Zn finger	876..893	CDD:275368
		C2H2 Zn finger	904..924	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910