DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dwg and zbtb41

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001116901.1	Gene:	zbtb41 / 100144660	XenbaseID:	XB-GENE-877334	Length:	848	Species:	Xenopus tropicalis

Alignment Length:	654	Identity:	150/654 - (22%)
Similarity:	242/654 - (37%)	Gaps:	157/654 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 HCLQLLEQAFNFKR-----------------MVIDSDELLRLGLDEARC----SSFHESQTHSPN 111
            |...|..:.|.:|:                 ::.|||...|......:|    .:..|.::...:
Frog   192 HKCPLCRKVFCYKKTLENHMGKAHAERDPGDILEDSDHSTRKSTRRRKCPVKFENGGELESDGIS 256

  Fly   112 QSQQHDQQQQAFDSTEEYVMIEMLNEEQENVANLDEELAEEDRRIFAMTVDEEEEFLTEEVDQDD 176
            .|:......:..||.:..      ||..|..:.|::.:..:|.....:..:|:.|...||:::.:
Frog   257 SSESSKSSMERADSGDSG------NEINEETSGLEDNVQGDDGEETLVPNNEQSEGEPEEMEERN 315

  Fly   177 ELS-------------------------------------EEEHQLAQSGDQQEEHITMESVHEF 204
            |.|                                     .|.|....:|::..|   .:..|:
Frog   316 EFSGALANYPDGLNPVLLHKDGKKVLRCPKCDKVFDRVGKYESHTRVHTGEKPFE---CDICHQ- 376

  Fly   205 QPAEVEYVTI-----KNEFETIVTEEDEFEVMNDSGAHDAILDCQMIVIPAEGAIDEVIGEETLE 264
            :.:....:|:     .||.|....::.:....|...|....|...:.....|.|      :|.|.
Frog   377 RYSTKSNLTVHRKRHNNETEIHRKKKHKCPFCNKPHASRKTLSKHVKRFHPENA------QEFLS 435

  Fly   265 L---EGDG---------------REEHLLPEAED------VCEDEDFLEESLDSAPPTAGEALPY 305
            |   :.||               .|||::..::|      .|| |.|................|:
Frog   436 LKRIKNDGWKCDVCNKSFTRRPHLEEHMILHSQDKPFKCTYCE-EHFKSRFTRLKHQEKFHLGPF 499

  Fly   306 VCTVCQKAFRQQCRLNQHMR-SHVDEKQYECEECGKRLKHLRNYKEHMLTHTNVKPHQCSICGRF 369
            .|.:|.:.|.....:.:|:. :|..::::.|..|||.::.....|||:..|:..|||.|||||:.
Frog   500 PCNICGRHFNDTGNMKRHIEYTHGGKRKWTCFICGKSVRERTTLKEHLRIHSGEKPHLCSICGQS 564

  Fly   370 YRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDLCDKAYYDSSSLRQ 434
            :|..||..:|.|.|.:.|.|.|::||:.:...|||.:||..|:||:.:.|:.|.|.:.....|..
Frog   565 FRHGSSYRLHLRVHHDDKRYECEECGKTFIRHDHLTKHKKIHSGEKAHQCEECGKCFGRRDHLTV 629

  Fly   435 H-KISHTGKKAF--------TCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTSNLNA 490
            | |..|.|:|.:        .||:|......||..:.|...|||.|.:||.:|..:|.....|..
Frog   630 HYKSVHLGEKVWQKYKATFHQCEVCKKVFKGKSSLEMHFRTHSGEKPYKCHICNQSFRIKKTLTK 694

  Fly   491 HVRLHSGEKPFKCEVCVKAFPTKKRLASHM-RVHN--------------KESPV-----TATVAV 535
            |:.:||..:||.|:.|...|..|.:|..|: .||.              |..||     :|.:.|
Frog   695 HLVIHSDARPFNCQHCNATFKRKDKLKYHIDHVHGSKVAEEEMGADEEPKSFPVVSENTSADICV 759

  Fly   536 QSINPPSRQAGAEGATGGGATGGSPTGGGA---------------TGGSATNLHITEVHEQPVST 585
            .....|...|.:| |..|..||.|.....|               |...||.||       ||..
Frog   760 PLTLVPIEMAESE-ADLGRHTGSSALPSAAEYQPSDLAFLEKYTLTPQPATLLH-------PVRP 816

  Fly   586 SKVV 589
            .:::
Frog   817 DQIL 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871	7/39 (18%)
		COG5048	<297..451	CDD:227381	52/163 (32%)
		C2H2 Zn finger	307..327	CDD:275368	4/20 (20%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	10/19 (53%)
		COG5048	<387..523	CDD:227381	48/145 (33%)
		C2H2 Zn finger	391..411	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	419..439	CDD:275368	6/20 (30%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		C2H2 Zn finger	475..495	CDD:275368	5/19 (26%)
		zf-H2C2_2	487..510	CDD:290200	8/22 (36%)
		C2H2 Zn finger	503..523	CDD:275368	6/20 (30%)
zbtb41	NP_001116901.1	BTB_POZ_ZBTB41	55..168	CDD:349535
		COG5048	338..725	CDD:227381	103/397 (26%)
		C2H2 Zn finger	343..363	CDD:275368	2/19 (11%)
		C2H2 Zn finger	371..391	CDD:275368	2/20 (10%)
		C2H2 Zn finger	405..423	CDD:275368	3/17 (18%)
		C2H2 Zn finger	446..466	CDD:275368	3/19 (16%)
		C2H2 Zn finger	474..495	CDD:275368	4/21 (19%)
		C2H2 Zn finger	501..522	CDD:275368	4/20 (20%)
		C2H2 Zn finger	530..550	CDD:275368	7/19 (37%)
		C2H2 Zn finger	558..578	CDD:275368	10/19 (53%)
		C2H2 Zn finger	586..606	CDD:275368	8/19 (42%)
		C2H2 Zn finger	614..632	CDD:275368	5/17 (29%)
		C2H2 Zn finger	651..668	CDD:275368	5/16 (31%)
		C2H2 Zn finger	679..699	CDD:275368	5/19 (26%)
		C2H2 Zn finger	707..724	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910