DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dwg and ZNF316

DIOPT Version :9

Sequence 1:	NP_477338.3	Gene:	dwg / 31265	FlyBaseID:	FBgn0000520	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001265488.1	Gene:	ZNF316 / 100131017	HGNCID:	13843	Length:	1004	Species:	Homo sapiens

Alignment Length:	297	Identity:	102/297 - (34%)
Similarity:	139/297 - (46%)	Gaps:	20/297 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 DSAPPT-AGEALPYVCTVCQKAFRQQCRLNQHMRSHVDEKQYECEECGKRLKHLRNYKEHMLTHT 356
            :.||.. |.|..|::|:.|.|.|.::..|.:|.|.|..|:.:.|.:|||...:..:...|..|||
Human   678 EPAPAALAEEESPWICSDCGKTFGRRAALAKHQRYHAGERPHRCADCGKSFVYGSHLARHRRTHT 742

  Fly   357 NVKPHQCSICGRFYRTTSSLAVHKRTHAEKKPYNCDQCGRGYAAFDHLRRHKLTHTGERPYACDL 421
            ..:|..|..||..:...|.||.|.|.|..:||:.|..||.|::...||..|...|||||||||..
Human   743 GERPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGVCGAGFSRRAHLTAHGRAHTGERPYACGE 807

  Fly   422 CDKAYYDSSSLRQHKISHTGKKAFTCEICGVGLSQKSGYKKHMMVHSGVKAHKCDVCGHAFTFTS 486
            |.:.:..|::|.:|:.:|..:|...|..||.|....|.:|:|...|:|.|..:|..||..|...|
Human   808 CGRRFGQSAALTRHQWAHAEEKPHRCPDCGKGFGHSSDFKRHRRTHTGEKPFRCADCGRGFAQRS 872

  Fly   487 NLNAHVRLHSGEKPFKCEVCVKAFPTKKRLASHMRVHNKESPVTATVAVQSINPPSR-------Q 544
            ||..|.|.|:||:||.|..|.|.|..:..|.:|.|.|..|.|.......:..:..|.       .
Human   873 NLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRTHTGERPYACANCGRRFSQSSHLLTHMKTH 937

  Fly   545 AGAEGATGGG------------ATGGSPTGGGATGGS 569
            .||..|.|.|            |.|.|..|.|..|.:
Human   938 RGATAAPGSGSAPAPAPKPEAAAKGPSSAGPGERGSA 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dwg	NP_477338.3	zf-AD	14..91	CDD:214871
		COG5048	<297..451	CDD:227381	55/154 (36%)
		C2H2 Zn finger	307..327	CDD:275368	7/19 (37%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		COG5048	<387..523	CDD:227381	55/135 (41%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	419..439	CDD:275368	5/19 (26%)
		C2H2 Zn finger	447..467	CDD:275368	7/19 (37%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..510	CDD:290200	12/22 (55%)
		C2H2 Zn finger	503..523	CDD:275368	7/19 (37%)
ZNF316	NP_001265488.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..148
		KRAB	158..218	CDD:214630
		COG5048	<345..503	CDD:227381
		C2H2 Zn finger	347..367	CDD:275368
		C2H2 Zn finger	375..395	CDD:275368
		C2H2 Zn finger	403..423	CDD:275368
		C2H2 Zn finger	431..451	CDD:275368
		C2H2 Zn finger	459..479	CDD:275368
		C2H2 Zn finger	487..505	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..574
		C2H2 Zn finger	693..713	CDD:275368	7/19 (37%)
		zf-H2C2_2	705..730	CDD:316026	9/24 (38%)
		C2H2 Zn finger	721..741	CDD:275368	5/19 (26%)
		COG5048	<746..933	CDD:227381	69/186 (37%)
		C2H2 Zn finger	749..769	CDD:275368	8/19 (42%)
		C2H2 Zn finger	777..797	CDD:275368	7/19 (37%)
		C2H2 Zn finger	805..825	CDD:275368	5/19 (26%)
		C2H2 Zn finger	833..853	CDD:275368	7/19 (37%)
		C2H2 Zn finger	861..881	CDD:275368	9/19 (47%)
		C2H2 Zn finger	889..909	CDD:275368	7/19 (37%)
		C2H2 Zn finger	917..937	CDD:275368	1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	936..976		11/39 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910