Protein Alignment fs(1)Yb and TDRD12

DIOPT Version :10

• Sequence 1: NP_477494.2
• Gene: fs(1)Yb / 31262
• FlyBaseID: FBgn0000928
• Length: 1042
• Species: Drosophila melanogaster
• Sequence 2: NP_001424876.1
• Gene: TDRD12 / 91646
• HGNCID: 25044
• Length: 1335
• Species: Homo sapiens
• Alignment Length: 900
• Identity: 183/900 - (20%)
• Similarity: 339/900 - (37%)
• Gaps: 226/900 - (25%)

  Fly   192 PPTSSED--YKAEADVLLSAATPATIPNDNKEQEIN-LSVEDATVKLLASF----ELGSTDSAAV 249
            |..:::|  .|...|.|..:      |.|..|::.: :|::|...::.:|.    :.|.|..|..
Human   283 PTATAQDKAVKCNMDSLRDS------PKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADP 341

  Fly   250 D--ESSPAAAKFNAPVYSPFVTENPTKSLD-AEFQELVKSFKVQNVFKNMNLPPPPSVSIEEPVS 311
            |  |:|..:.|.|         |.|.:..: .|:.|.....|:.. |.|           .:|:.
Human   342 DVPEASALSQKSN---------EKPLRLTEKKEYDEKNSCVKLLQ-FLN-----------PDPLR 385

  Fly   312 SASASDYRHQIDTTSLDSIRTVKDSPASLAVVPFSAGGITYNNYGVLGWSRHAVVPCYGLTEAPD 376
            :...||         |..::.:|.....:.|:                  |:.:.||..:..:|
Human   386 ADGISD---------LQQLQKLKGLQPPVVVL------------------RNKIKPCLTIDSSP- 422

  Fly   377 ISTIIRRAMQQ---MGVARSRARAVQRFAWPHVSLGKSVLVVGNLQIGKTWSYLP--TVCQRS-- 434
            :|..:::|:|:   .|.:.:     :.::||.::.|..|:|:.:.:.......||  ||.|..
Human   423 LSADLKKALQRNKFPGPSHT-----ESYSWPPIARGCDVVVISHCESNPLLYLLPVLTVLQTGAC 482

  Fly   435 HEDLQRRPDVGRGPTCIFVCPN----------QGQGKQIERWMSTLLCLLGSASGFEDVVTHWDK 489
            ::.|..|    .||..:.|||.          .|:.....|.:..:|..:|         .|.::
Human   483 YKSLPSR----NGPLAVIVCPGWKKAQFIFELLGEYSMSSRPLHPVLLTIG---------LHKEE 534

  Fly   490 TQLVDIVRRLKKPVG--ILLTSVDLLLQLLNHNPVGSIFDAQAVKCIALDNL-NDMVRVLPNDTM 551
                  .:..|.|.|  :::|:...||:||         ..|::..:.|.:| .|.|.||
Human   535 ------AKNTKLPRGCDVIVTTPYSLLRLL---------ACQSLLFLRLCHLILDEVEVL----- 579

  Fly   552 KLLQRLPEMFQLTQN-------------KCQLLVSGRIWHTDLMVQHIL-PLMPDVLVLFDDALE 602
             .|:...:||.:..|             ..|::..|..|:..  ::|:: ..|.|..::.....|
Human   580 -FLEANEQMFAILDNFKKNIEVEERESAPHQIVAVGVHWNKH--IEHLIKEFMNDPYIVITAMEE 641

  Fly   603 ASVYGGVQLDVRVVADEPEKIEHLKALIAERRNFANEPAVMVCS-NSTEVLLLRRSLQAIGVNAH 666
            |::||.||..|.:.. |.||...|...:....:.|.:..:..|| ..||::     .:.:..::.
Human   642 AALYGNVQQVVHLCL-ECEKTSSLLQALDFIPSQAQKTLIFTCSVAETEIV-----CKVVESSSI 700

  Fly   667 ICV---SEACYS--NVAE-WLRQSPSG---LLLVTDDVVPRLKCGKIPLLIHYSFASMWARFKNR 722
            .|:   .|..::  ||.| |.::..||   :|.:|||.||.|.......:||:||.:....|..|
Human   701 FCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDDCVPLLAITDATCVIHFSFPASPKVFGGR 765

  Fly   723 F----SLFYANLKSPTTR--PVGQSVVFAKPTDLENIWKLCDFYMKHKLPRPGHL----LGILSQ 777
            .    ..|:|...||..:  ...:||:.....|..:...:..:..:.....|..|    .|:|..
Human   766 LYCMSDHFHAEQGSPAEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAELYEFTAGVLEA 830

  Fly   778 RRLEEQPTSRSLCHQMAAFGDCLRHKCMYRHVMWRDEVLPPDHY---PKNGLIRFLVLVCYSPAA 839
            :  |::...|.||..:.|||.|       .|.::||:.:.||.:   |:..|.|
Human   831 K--EDKKAGRPLCPYLKAFGFC-------NHFIFRDKRICPDRHRINPETDLPR----------- 875

  Fly   840 LAVRLSDQ-FPT--AIRFLNFPMSD----LGERVQRHYELEA--NRHMHPNPVPGEMAVVKNINR 895
               :||.| .|:  .|:.:.|.:.:    .|..|.:|.:|.|  |..|:..........|:.:.:
Human   876 ---KLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAEMNEYFKDSNKTTVEKVEK 937

  Fly   896 -----------YERVHIVSVESNV------MVLVQLLDTSTECFSYKTSQLYSCDKIFKDSPREA 943
                       :.||.::.|....      .:||:.:|........: .||....:.|...|.:|
Human   938 FGLYGLAEKTLFHRVQVLEVNQKEDAWALDDILVEFIDEGRTGLVTR-DQLLHLPEHFHTLPPQA 1001

  Fly   944 MDLRILGLQPESLDRIWPDDARNLVRKDFFRRTHNKRNRQFHAVVQSAIHRTIFV 998
            ::..:..::|...:..|.......:......:.|:       |.|..|:..|:::
Human  1002 VEFIVCRVKPADNEIEWNPKVTRYIHHKIVGKLHD-------AKVILALGNTVWI 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)Yb	NP_477494.2	Tudor_SF	<862..960	CDD:470623	20/116 (17%)
TDRD12	NP_001424876.1	None