DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)Yb and TDRD12

DIOPT Version :9

Sequence 1:	NP_477494.2	Gene:	fs(1)Yb / 31262	FlyBaseID:	FBgn0000928	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	XP_011525773.1	Gene:	TDRD12 / 91646	HGNCID:	25044	Length:	1335	Species:	Homo sapiens

Alignment Length:	900	Identity:	183/900 - (20%)
Similarity:	339/900 - (37%)	Gaps:	226/900 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 PPTSSED--YKAEADVLLSAATPATIPNDNKEQEIN-LSVEDATVKLLASF----ELGSTDSAAV 249
            |..:::|  .|...|.|..:      |.|..|::.: :|::|...::.:|.    :.|.|..|..
Human   283 PTATAQDKAVKCNMDSLRDS------PKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADP 341

  Fly   250 D--ESSPAAAKFNAPVYSPFVTENPTKSLD-AEFQELVKSFKVQNVFKNMNLPPPPSVSIEEPVS 311
            |  |:|..:.|.|         |.|.:..: .|:.|.....|:.. |.|           .:|:.
Human   342 DVPEASALSQKSN---------EKPLRLTEKKEYDEKNSCVKLLQ-FLN-----------PDPLR 385

  Fly   312 SASASDYRHQIDTTSLDSIRTVKDSPASLAVVPFSAGGITYNNYGVLGWSRHAVVPCYGLTEAPD 376
            :...||         |..::.:|.....:.|:                  |:.:.||..:..:|
Human   386 ADGISD---------LQQLQKLKGLQPPVVVL------------------RNKIKPCLTIDSSP- 422

  Fly   377 ISTIIRRAMQQ---MGVARSRARAVQRFAWPHVSLGKSVLVVGNLQIGKTWSYLP--TVCQRS-- 434
            :|..:::|:|:   .|.:.:     :.::||.::.|..|:|:.:.:.......||  ||.|..
Human   423 LSADLKKALQRNKFPGPSHT-----ESYSWPPIARGCDVVVISHCESNPLLYLLPVLTVLQTGAC 482

  Fly   435 HEDLQRRPDVGRGPTCIFVCPN----------QGQGKQIERWMSTLLCLLGSASGFEDVVTHWDK 489
            ::.|..|    .||..:.|||.          .|:.....|.:..:|..:|         .|.::
Human   483 YKSLPSR----NGPLAVIVCPGWKKAQFIFELLGEYSMSSRPLHPVLLTIG---------LHKEE 534

  Fly   490 TQLVDIVRRLKKPVG--ILLTSVDLLLQLLNHNPVGSIFDAQAVKCIALDNL-NDMVRVLPNDTM 551
                  .:..|.|.|  :::|:...||:||         ..|::..:.|.:| .|.|.||
Human   535 ------AKNTKLPRGCDVIVTTPYSLLRLL---------ACQSLLFLRLCHLILDEVEVL----- 579

  Fly   552 KLLQRLPEMFQLTQN-------------KCQLLVSGRIWHTDLMVQHIL-PLMPDVLVLFDDALE 602
             .|:...:||.:..|             ..|::..|..|:..  ::|:: ..|.|..::.....|
Human   580 -FLEANEQMFAILDNFKKNIEVEERESAPHQIVAVGVHWNKH--IEHLIKEFMNDPYIVITAMEE 641

  Fly   603 ASVYGGVQLDVRVVADEPEKIEHLKALIAERRNFANEPAVMVCS-NSTEVLLLRRSLQAIGVNAH 666
            |::||.||..|.:.. |.||...|...:....:.|.:..:..|| ..||::     .:.:..::.
Human   642 AALYGNVQQVVHLCL-ECEKTSSLLQALDFIPSQAQKTLIFTCSVAETEIV-----CKVVESSSI 700

  Fly   667 ICV---SEACYS--NVAE-WLRQSPSG---LLLVTDDVVPRLKCGKIPLLIHYSFASMWARFKNR 722
            .|:   .|..::  ||.| |.::..||   :|.:|||.||.|.......:||:||.:....|..|
Human   701 FCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDDCVPLLAITDATCVIHFSFPASPKVFGGR 765

  Fly   723 F----SLFYANLKSPTTR--PVGQSVVFAKPTDLENIWKLCDFYMKHKLPRPGHL----LGILSQ 777
            .    ..|:|...||..:  ...:||:.....|..:...:..:..:.....|..|    .|:|..
Human   766 LYCMSDHFHAEQGSPAEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAELYEFTAGVLEA 830

  Fly   778 RRLEEQPTSRSLCHQMAAFGDCLRHKCMYRHVMWRDEVLPPDHY---PKNGLIRFLVLVCYSPAA 839
            :  |::...|.||..:.|||.|       .|.::||:.:.||.:   |:..|.|
Human   831 K--EDKKAGRPLCPYLKAFGFC-------NHFIFRDKRICPDRHRINPETDLPR----------- 875

  Fly   840 LAVRLSDQ-FPT--AIRFLNFPMSD----LGERVQRHYELEA--NRHMHPNPVPGEMAVVKNINR 895
               :||.| .|:  .|:.:.|.:.:    .|..|.:|.:|.|  |..|:..........|:.:.:
Human   876 ---KLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAEMNEYFKDSNKTTVEKVEK 937

  Fly   896 -----------YERVHIVSVESNV------MVLVQLLDTSTECFSYKTSQLYSCDKIFKDSPREA 943
                       :.||.::.|....      .:||:.:|........: .||....:.|...|.:|
Human   938 FGLYGLAEKTLFHRVQVLEVNQKEDAWALDDILVEFIDEGRTGLVTR-DQLLHLPEHFHTLPPQA 1001

  Fly   944 MDLRILGLQPESLDRIWPDDARNLVRKDFFRRTHNKRNRQFHAVVQSAIHRTIFV 998
            ::..:..::|...:..|.......:......:.|:       |.|..|:..|:::
Human  1002 VEFIVCRVKPADNEIEWNPKVTRYIHHKIVGKLHD-------AKVILALGNTVWI 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)Yb	NP_477494.2	TUDOR	<859..948	CDD:278965	19/111 (17%)
TDRD12	XP_011525773.1	TUDOR	10..128	CDD:278965
		TUDOR	60..109	CDD:119391
		P-loop_NTPase	419..635	CDD:304359	52/257 (20%)
		SrmB	422..881	CDD:223587	118/529 (22%)
		P-loop_NTPase	659..762	CDD:304359	27/107 (25%)
		TUDOR	<913..1004	CDD:278965	15/91 (16%)
		alpha-crystallin-Hsps_p23-like	1193..1297	CDD:294116
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108496
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810