DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)Yb and BoYb

DIOPT Version :9

Sequence 1:	NP_477494.2	Gene:	fs(1)Yb / 31262	FlyBaseID:	FBgn0000928	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_649430.1	Gene:	BoYb / 40512	FlyBaseID:	FBgn0037205	Length:	1059	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	175/758 - (23%)
Similarity:	323/758 - (42%)	Gaps:	118/758 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   325 TSLDSIRTVKDSPAS------LAVVPFSAGGITYNNYGVLGWSRHAVVPCYGLTEAPDISTIIRR 383
            :|.||:..|.||.:.      |.....|...:.:.|..:....|.|.|     :..||    |..
  Fly    12 SSRDSVYEVGDSYSGQNANRPLVATNCSEYAVAHANCQLRPVRRFAEV-----SLLPD----ILE 67

  Fly   384 AMQQMGVARSRARAVQRFAWPHVS--LGKSVLVVGNLQIGKTWSYLPTVCQR----------SHE 436
            .|:.:|:  :|...:|.:.|||::  .|...::||:...|:|::|:|.||..          ..|
  Fly    68 TMRNLGL--NRLLRLQSYTWPHLAGGSGHGAMIVGSPASGRTFAYIPPVCHAVSRALMDFTGQCE 130

  Fly   437 DLQR---RPDVGRGPTCIFVCPNQGQGKQIERWMSTLLCLLGSASGFEDVVT---HWDKTQLVDI 495
            |::.   :|| ..||..:.:.|:.   :::.:..:..|.||..|.. .|.||   :...|:....
  Fly   131 DVEHDISQPD-RYGPIALILVPDL---RRVHQVSAMCLALLRKAHK-NDSVTLALNVSSTKSSQF 190

  Fly   496 VRRLKKPVGILLTSVDLLLQLLNHNPVGSIFDAQAVKCIALDNLNDMVRVLPNDTMKLLQRLPEM 560
            ..:|...||.|:.:...|:......|  .:.....::.:..|:::.|.|....|..::||   |:
  Fly   191 FLKLLNGVGCLVATPAQLVWFWQEAP--GLMRFPCLQFLVYDDVDLMSREQLQDVQQVLQ---EI 250

  Fly   561 FQLTQNKCQLLVSGRIWHTDLMVQHILPLMPDVLVLFDDALEASVYGGVQLDVRVVADEPEKIEH 625
            ..|:.:...::||....||  ::..:..:.....::|.|.|||::|||.::.:.::..|.:
  Fly   251 LPLSHSPQVVMVSKSYCHT--LMSKLRAVNDKPALVFGDILEAALYGGTRIRISIMRSEAK---- 309

  Fly   626 LKALIAERRNFANEP--AVMVCSNSTEVLLLRRSLQAIGVNAHICVSEACYSNVAE--------- 679
            ..|::...:..:.|.  .|:.||:..::..|   :.|:.|..:.|:.   |...|:
  Fly   310 ANAVVQMLQQCSPEEFRTVIFCSDDGDMQCL---VAALEVQHYSCLP---YYQTADLEVRQQVHS 368

  Fly   680 WLRQSPSGLLLVTDDVVPRLKCGKIPLLIHYSFASMWARFKNR---FSLFYANLKSPTTRPVGQ- 740
            |..:| :|::|:..|..|.|.......:||:|.:..|::||.|   .|....|:..||...|.:
  Fly   369 WQARS-NGVILLCTDNCPELDIRDAHTIIHHSMSHSWSKFKLRHLKISDNLCNMVKPTASIVKKP 432

  Fly   741 --SVVFAKPTDLENIWKLCDFYMKHKLPRPGHLLGILSQRRLEEQPTSRS----LCHQMAAFGDC 799
              |:|.....:...:.:|.||...|:  :..|.|..:::|..:|...:|:    ||.|:...|.|
  Fly   433 LYSLVLLDDNNHRQLPRLVDFLQLHQ--KVDHRLVEVAKRIRQELGKARNDQHQLCDQILVLGKC 495

  Fly   800 LRHKCMYRHVMWRDEVLPPDHYPKNGLIRFLVLVCYSPAALAVRLSDQFPTAIRFLNFPMSDLGE 864
            ....|..||.:...: ..||:.|.:|.::..::..|||....|||.:..|....:.....|.:.|
  Fly   496 YDPVCESRHRLSHID-RRPDYLPASGDVKVQLVKVYSPTHFCVRLLEHLPPKGTWRMMEYSAVQE 559

  Fly   865 RVQRHYELEANRHMHPNPVPGEMAVVKNINRYERVHIVS---------VESNVMVLVQLLDTSTE 920
            ...:..:::..|...| ||.|.:.:.......|||.::.         |:|::.|.:|.||..|.
  Fly   560 FRMQLTQIKEPRRYWP-PVAGAICMYHTTFTKERVRVLKVAAIKNTNIVQSDLTVKLQALDVDTR 623

  Fly   921 CFSYKTSQLYSCDKIFKDSPREAMDLRILGLQPESLDRIWPDD-ARNL------VRKDFFRRTHN 978
            .||....:|:.|.:..:.....|.|||:.|..|...:|.|.:: .||:      :.||.|
  Fly   624 IFSTNCGKLFECPEALQQEAPLACDLRLPGWVPYFGERSWTEENIRNVNLILTQLPKDHF----- 683

  Fly   979 KRNRQFHAVVQSAIHRTIFVRNIYDDEGNDLLSFV-INRFRSH 1020
                 ..|.:......|:||:        ||::.: .::|::|
  Fly   684 -----LQAKILFVAAGTLFVQ--------DLVAIMYADQFKAH 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)Yb	NP_477494.2	TUDOR	<859..948	CDD:278965	24/97 (25%)
BoYb	NP_649430.1	P-loop_NTPase	81..263	CDD:304359	42/191 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470066
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0334
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0016799
OrthoInspector	1	1.000	-	-		otm26337
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840