DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fs(1)Yb and DDX42

DIOPT Version :9

Sequence 1:	NP_477494.2	Gene:	fs(1)Yb / 31262	FlyBaseID:	FBgn0000928	Length:	1042	Species:	Drosophila melanogaster
Sequence 2:	NP_031398.2	Gene:	DDX42 / 11325	HGNCID:	18676	Length:	938	Species:	Homo sapiens

Alignment Length:	658	Identity:	123/658 - (18%)
Similarity:	217/658 - (32%)	Gaps:	203/658 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 PELNKFEERLKWLSISARNAEMLVITPCDEENEKEGKGETEPEIVQQRMPLKVDALNSMQLYEIK 188
            |:|..|      ..|.::.|..      ||||   ...|.|.|          |:.|....|...
Human    54 PQLPSF------YKIGSKRANF------DEEN---AYFEDEEE----------DSSNVDLPYIPA 93

  Fly   189 ENTPPTSSEDYKAEADVLLSAATPATIPNDNKEQEINLSVEDATVKLLASFE---------LGST 244
            ||: ||..:.:....|         :..:|:..:.....|||...:.:...|         .|..
Human    94 ENS-PTRQQFHSKPVD---------SDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIR 148

  Fly   245 DSAAVDESSPAAAKFNAPVYSPFVTENPTKSLDAEFQELVKSFKVQNV-FKNMNLPPPPSVSIEE 308
            |....::...|        |..::.||||..:..|.:|       .|: :.:...|..|:..|.:
Human   149 DDIEEEDDQEA--------YFRYMAENPTAGVVQEEEE-------DNLEYDSDGNPIAPTKKIID 198

  Fly   309 PVSSASASD----------YRHQIDTTSLD-----SIRTVKDSPASLAVVPFSAGGITYNNYGVL 358
            |:.....|:          |....:.|:|.     .:|...:...|.|..|  ..|.::.::|..
Human   199 PLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPP--RPGSSFAHFGFD 261

  Fly   359 GWSRHAV----------VPCYGLTEAPDISTIIRRAMQQMGVARSRARAVQRFAWPHVSLGKSVL 413
            ....|.:          :.|.|:..|     :..|.|  :|:|::.:.....|.||       :|
Human   262 EQLMHQIRKSEYTQPTPIQCQGVPVA-----LSGRDM--IGIAKTGSGKTAAFIWP-------ML 312

  Fly   414 VVGNLQIGKTWSYLPTVCQRSHEDLQRRPDVGRGPTCIFVCPNQGQGKQIERWMSTLLCLLGSAS 478
            :                    |...|:..:.|.||..:.|||.:...:||......    .|.|.
Human   313 I--------------------HIMDQKELEPGDGPIAVIVCPTRELCQQIHAECKR----FGKAY 353

  Fly   479 GFEDVVTH-----WDKT---------------QLVDIVRRLKKPVGILLTSVDLLLQLLNHNPVG 523
            ....|..:     |::.               :|:|.|:  ||...         ||.:::
Human   354 NLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVK--KKATN---------LQRVSY---- 403

  Fly   524 SIFDAQAVKCIALDNLNDM-----VRVLPNDTMKLLQRLPEMFQLT-QNKCQLLVSGRIWHTDLM 582
            .:||       ..|.:.||     ||.:.:......|.|  :|..| :.|.:.|.      .|::
Human   404 LVFD-------EADRMFDMGFEYQVRSIASHVRPDRQTL--LFSATFRKKIEKLA------RDIL 453

  Fly   583 VQHILPLMPDVLVLFDDALEASVYGGVQLDVRVVADEPEKIEHLKALIAERRNFANEPAVMVC-- 645
            :..|..:..|:....:|..:.         |.::...|.|...|...:.|   |.:..:|::.
Human   454 IDPIRVVQGDIGEANEDVTQI---------VEILHSGPSKWNWLTRRLVE---FTSSGSVLLFVT 506

  Fly   646 --SNSTEVLLLRRSLQAIGVN---AHICVSEACYSNVAEWLRQSPSGLLLVTDDVVPRLKCGKIP 705
              :|:.|   |..:|:..|.|   .|..:.::..:.|....::....:|:.||.....|....|.
Human   507 KKANAEE---LANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIK 568

  Fly   706 LLIHYSFA 713
            .:|:|..|
Human   569 TVINYDVA 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fs(1)Yb	NP_477494.2	TUDOR	<859..948	CDD:278965
DDX42	NP_031398.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..114		20/94 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203		4/20 (20%)
		Q motif	253..281		2/27 (7%)
		PRK10590	254..688	CDD:236722	74/406 (18%)
		DEADc	255..459	CDD:238167	49/271 (18%)
		DEAD box	407..410		1/9 (11%)
		HELICc	470..601	CDD:238034	24/122 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..938
		Necessary for interaction with TP53BP2. /evidence=ECO:0000269\|PubMed:19377511	738..833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910